Acute Hemorrhagic Leukoencephalitis (Hurst Syndrome)

A fulminant and often fatal demyelinating disease of the brain which primarily affects young adults and children. Clinical features include the rapid onset of weakness, SEIZURES, and COMA. It may follow a viral illness or MYCOPLASMA PNEUMONIAE infections but in most instances there is no precipitating event. Pathologic examination reveals marked perivascular demyelination and necrosis of white matter with microhemorrhages. (Adams et al., Principles of Neurology, 6th ed, pp924-5)
Also Known As:
Hurst Syndrome; Syndrome, Hurst; Leukoencephalitis, Acute Hemorrhagic; Encephalomyelitis, Acute Necrotizing Hemorrhagic; Encephalomyelitis, Hemorrhagic Necrotizing; Encephalomyelitis, Necrotizing Hemorrhagic; Hemorrhagic Encephalomyelitis, Necrotizing; Hemorrhagic Necrotizing Encephalomyelitis; Hurst's Disease; Leukoencephalitis Acuta Hemorrhagica; Leukoencephalitis, Subacute Hemorrhagic; Necrotizing Encephalomyelitis, Hemorrhagic; Acute Hemorrhagic Leukoencephalitides; Acute Necrotizing Encephalitides; Acute Necrotizing Encephalitis; Disease, Hurst; Disease, Hurst's; Encephalitides, Acute Necrotizing; Encephalomyelitides, Hemorrhagic Necrotizing; Hemorrhagic Encephalomyelitides, Necrotizing; Hemorrhagic Leukoencephalitides, Acute; Hemorrhagic Leukoencephalitides, Subacute; Hemorrhagic Leukoencephalitis, Acute; Hemorrhagic Leukoencephalitis, Subacute; Hursts Disease; Leukoencephalitides, Acute Hemorrhagic; Leukoencephalitides, Subacute Hemorrhagic; Necrotizing Encephalitides, Acute; Necrotizing Encephalitis, Acute; Necrotizing Encephalomyelitides, Hemorrhagic; Necrotizing Hemorrhagic Encephalomyelitides; Subacute Hemorrhagic Leukoencephalitides; Subacute Hemorrhagic Leukoencephalitis; Encephalitis, Acute Necrotizing; Hurst Disease; Necrotizing Hemorrhagic Encephalomyelitis
Networked: 14 relevant articles (0 outcomes, 0 trials/studies)

Disease Context: Research Results

Related Diseases

1. Acute Hemorrhagic Leukoencephalitis (Hurst Syndrome)
2. Malformations of Cortical Development
3. Lissencephaly
4. Herpes Simplex Encephalitis (Herpes Encephalitis)
5. Neurocutaneous Syndromes (Phakomatoses)


1. Takanashi, Jun-ichi: 1 article (05/2014)
2. Putnam, Christopher D: 1 article (01/2013)
3. Gandhi, Chhavi: 1 article (01/2013)
4. Newbury, Robert O: 1 article (01/2013)
5. Giclas, Patricia C: 1 article (01/2013)
6. Aceves, Seema S: 1 article (01/2013)
7. Hoffman, Hal M: 1 article (01/2013)
8. Broderick, Lori: 1 article (01/2013)
9. Peterson, Karin S: 1 article (01/2013)
10. Sheets, Robert M: 1 article (01/2013)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Acute Hemorrhagic Leukoencephalitis:
1. AntigensIBA
2. Complement Factor I (C3b Inactivator)IBA
3. N-Methylaspartate (NMDA)IBA
4. SteroidsIBA
5. ParaffinIBA
6. OxidoreductasesIBA
7. MethylprednisoloneFDA LinkGeneric
8. Biotin (Vitamin H)FDA Link
9. AntibodiesIBA
10. Lennox-Gastaut type Epileptic encephalopathyIBA

Therapies and Procedures

1. Surgical Decompression
2. Intensive Care (Surgical Intensive Care)
3. Plasmapheresis
4. Plasma Exchange
5. Curettage