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Tick-Borne Encephalitis (Encephalitis, Tick Borne)

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Encephalitis caused by neurotropic viruses that are transmitted via the bite of TICKS. In Europe, the diseases are caused by ENCEPHALITIS VIRUSES, TICK-BORNE, which give rise to Russian spring-summer encephalitis, central European encephalitis, louping ill encephalitis, and related disorders. Powassan encephalitis occurs in North America and Russia and is caused by the Powassan virus. ASEPTIC MENINGITIS and rarely encephalitis may complicate COLORADO TICK FEVER which is endemic to mountainous regions of the western United States. (From Joynt, Clinical Neurology, 1996, Ch26, pp14-5)

Also Known As:

Encephalitis, Tick Borne; Encephalitis, Tick-Borne; Central European Encephalitis; Encephalitis, Central European; Encephalitis, European Tick-Borne; Encephalitis, Far Eastern Russian; Encephalitis, Louping Ill; Encephalitis, Russian Spring-Summer; European Tick-Borne Encephalitis; Louping Ill Encephalitis; Russian Spring-Summer Encephalitis; Encephalitides, European Tick-Borne; Encephalitides, Louping Ill; Encephalitides, Powassan; Encephalitides, Tick-Borne; Encephalitis, European Tick Borne; Encephalitis, Powassan; Encephalitis, Russian Spring Summer; European Tick Borne Encephalitis; European Tick-Borne Encephalitides; Louping Ill Encephalitides; Powassan Encephalitides; Russian Spring Summer Encephalitis; Spring-Summer Encephalitis, Russian; Tick Borne Encephalitis; Tick-Borne Encephalitides; Tick-Borne Encephalitides, European; Tick-Borne Encephalitis, European; Far Eastern Russian Encephalitis; Powassan Encephalitis

Networked: 595 relevant articles (13 outcomes, 49 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Encephalomyelitis (Myeloencephalitis)
2.	Infection
3.	Yellow Fever
4.	Japanese Encephalitis
5.	Encephalitis (Encephalitis, Rasmussen)

Experts

1.	Kondrusik, Maciej: 11 articles (02/2015 - 01/2004)
2.	Heinz, Franz X: 10 articles (11/2013 - 04/2002)
3.	Pancewicz, Sławomir: 9 articles (02/2016 - 01/2004)
4.	Zajkowska, Joanna: 9 articles (02/2015 - 01/2004)
5.	Grygorczuk, Sambor: 9 articles (02/2015 - 03/2005)
6.	Hermanowska-Szpakowicz, Teresa: 9 articles (08/2007 - 01/2002)
7.	Zent, Olaf: 8 articles (03/2009 - 01/2003)
8.	Swierzbińska, Renata: 8 articles (01/2008 - 01/2004)
9.	Kariwa, Hiroaki: 6 articles (04/2014 - 03/2003)
10.	Zajkowska, J: 5 articles (10/2014 - 10/2000)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Tick-Borne Encephalitis:

1.	VaccinesIBA 01/01/2012 - "Vaccines from two manufacturers are available against tick-borne encephalitis, both considered effective and safe. " 05/01/2010 - "The paper shows variability of the functional activity of the superficial structures of three Far Eastern strains of tick-borne encephalitis (TBE) virus used to study the immunogenicity of different vaccines. " 01/01/2007 - "The Institute for Vaccine-Safety of the Austrian Green Cross, the so-called "Institut für Impfsicherheit des Osterreichischen Grünen Kreuzes", promoted a postmarketing sentinel study referring to the safety of tick-borne-encephalitis vaccines in spring 2002. " 08/01/2006 - "This review analyzes clinical studies investigating these two vaccines and describes possible approaches to boost or continue uncompleted primary immunization schedules, with either of the two tick-borne encephalitis vaccines." 01/01/2000 - "Randomised and quasi-randomised trials comparing tick-borne encephalitis vaccines against placebo, control vaccines or comparisons of different doses or schedules of tick-borne encephalitis vaccines. "
2.	Immunoglobulins (Immunoglobulin)IBA 01/01/1994 - "[The relationship of the therapeutic efficacy of immunoglobulin against tick-borne encephalitis to the specific activity of the preparation and the times of its administration]." 01/01/2013 - "To our knowledge, high dose intravenous immunoglobulin has not been tested systematically for treating severe cases of tick-borne encephalitis. " 01/01/2013 - "May early intervention with high dose intravenous immunoglobulin pose a potentially successful treatment for severe cases of tick-borne encephalitis?" 07/01/2010 - "[Metaanalysis of the efficiency of use of immunoglobulin preparations for the postexposure prophylaxis against tick-borne encephalitis in Russia]." 01/01/2010 - "[Efficiency of use of immunoglobulin preparations for the postexposure prevention of tick-borne encephalitis in Russia (a review of semi-centennial experience)]."
3.	InterferonsIBA 09/01/1995 - "Study of the interferon system parameters, natural killer activity, and immunologic characteristics in patients with acute tick-borne encephalitis confirmed that addition of interferon preparations to combined therapy is pathogenetically justified. " 09/01/1995 - "[The interferon system in acute tick-borne encephalitis and effect on the dynamics of clinical laboratory indicators using different methods of interferon therapy]." 01/01/1979 - "[Effect of a natural interferon inducer (RFf2) on the formation of vaccinal immunity to tick-borne encephalitis]." 01/01/1969 - "[Induction of interferon in the brain of baby mice by viruses of the tick-borne encephalitis (TBE) complex]." 01/01/1971 - "[Interferon production by 2 species of mice after infection with tick-borne encephalitis (TBE) virus. "
4.	Probucol (Lorelco)FDA Link 05/01/2009 - "[Preclinical and clinical studies of the efficacy of Panavir in therapy for tick-borne encephalitis]." 05/01/2009 - "The antiviral activity of Panavir was studied on a model of mice infected with the strain Sofjin of tick-borne encephalitis (TBE) virus. "
5.	Ribonucleases (Ribonuclease)IBA 01/01/1971 - "[Use of ribonuclease in the treatment of tick-borne encephalitis]." 02/01/1970 - "[Dynamics of specific antibody accumulation in patients with tick-borne encephalitis following ribonuclease therapy]." 01/01/1970 - "[Ribonuclease participation in the mechanism of the body's defense against viruses in tick-borne encephalitis]." 01/01/1968 - "[Ribonuclease therapy for tick-borne encephalitis]." 01/01/1992 - "To reveal the dependence of the efficacy of the treatment of tick-borne encephalitis (TBE) on the patient's HLA phenotype and to elaborate recommendations for individual treatment, 98 subjects who suffered TBE and who received different types of therapy in the acute period (isolated or combined use of specific homologous immunoglobulin and RNase) were subjected to immunogenetic examinations. "
6.	AcaricidesIBA 05/01/1968 - "[Efficacy of use of some phospho-organic compounds as acaricides in foci of tick-borne encephalitis]." 03/01/1972 - "[Effectiveness of application of organophosphous compounds as acaricides in foci of tick-borne encephalitis. " 05/01/1967 - "[Features of the immunological structure of the avian population of a territory of a tick-borne encephalitis focus treated with acaricides]." 01/01/1963 - "[ERADICATION OF NATURAL FOCI OF TICK-BORNE ENCEPHALITIS USING ACARICIDES]."
7.	Interleukin-1beta (Interleukin 1 beta)IBA 07/01/2001 - "The purpose of this work was to evaluate the changes of IL-1 beta and TNF-alpha serum concentrations among patients with TBE (tick-borne encephalitis) of mild and severe clinical course. " 03/01/1998 - "[Concentrations of tumor necrosis factor alpha and interleukin-1 beta in cerebrospinal fluid in the course of tick-borne encephalitis]." 03/01/1998 - "Detection of CSF concentrations of TNF-alpha and Il-1 beta in patients with tick-borne encephalitis can be used to evaluate efficacy of treatment and retreat of infection." 01/01/2003 - "An experiment with BALB/c mice, infected with a lethal dosage of the virus of tick-borne encephalitis (TE), strain 205, was accompanied by pronounced growing concentrations of the IL-1 beta, IL-6, IL-10 and TNF alpha cytokines in the blood serum of animals. "
8.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 07/01/2001 - "The purpose of this work was to evaluate the changes of IL-1 beta and TNF-alpha serum concentrations among patients with TBE (tick-borne encephalitis) of mild and severe clinical course. " 07/01/2001 - "[Tumor necrosis factor alpha and interleukin 1-beta in serum of patients with tick-borne encephalitis]." 03/01/1998 - "[Concentrations of tumor necrosis factor alpha and interleukin-1 beta in cerebrospinal fluid in the course of tick-borne encephalitis]." 03/01/1998 - "Detection of CSF concentrations of TNF-alpha and Il-1 beta in patients with tick-borne encephalitis can be used to evaluate efficacy of treatment and retreat of infection." 01/01/2003 - "An experiment with BALB/c mice, infected with a lethal dosage of the virus of tick-borne encephalitis (TE), strain 205, was accompanied by pronounced growing concentrations of the IL-1 beta, IL-6, IL-10 and TNF alpha cytokines in the blood serum of animals. "
9.	Immunologic Factors (Immunomodulators)IBA 07/01/2011 - "[Efficiency of coadministration of immunomodulators and vaccine in an experiment on tick-borne encephalitis]." 01/01/2001 - "[Effects of various interferon inducers and immunomodulators in tick-borne encephalitis]." 07/01/2011 - "Experiments on a tick-borne encephalitis (TBE) model in CBA and BALB/c mice demonstrated that immunomodulators (ridostin, polyribonate, and peptidoglycan-160) and a specific vaccine against TBE were significantly effective in increasing the level of a protective effect and life expectancy in the experimental group as compared to the control group. " 01/01/2011 - "The combined effects of immunomodulators, such as ridostin, polyribonate, glucose muramyl dipeptide, and peptidoglycan-160, and specific vaccines on survival of mice with alpha- (eastern equine encephalitis) and flavivirus (tick-borne encephalitis (TBE) infections were found to be significant. "
10.	ridostinIBA 07/01/2011 - "Experiments on a tick-borne encephalitis (TBE) model in CBA and BALB/c mice demonstrated that immunomodulators (ridostin, polyribonate, and peptidoglycan-160) and a specific vaccine against TBE were significantly effective in increasing the level of a protective effect and life expectancy in the experimental group as compared to the control group. " 01/01/2011 - "The combined effects of immunomodulators, such as ridostin, polyribonate, glucose muramyl dipeptide, and peptidoglycan-160, and specific vaccines on survival of mice with alpha- (eastern equine encephalitis) and flavivirus (tick-borne encephalitis (TBE) infections were found to be significant. "

Therapies and Procedures

1.	Immunotherapy 07/01/2000 - "[Experimental tick-borne encephalitis in golden hamsters treated with specific immunotherapy]." 11/01/1982 - "[Experimental basis of a protocol for the pathogenetic immunotherapy of tick-borne encephalitis]." 01/01/1981 - "[Immunotherapy of certain acute and chronic forms of neuroinfections (tick-borne encephalitis, multiple sclerosis, disseminated encephalomyelitis)]." 01/01/1981 - "As a result of using combined immunotherapy methods the authors have obtained positive results in treating 38 patients suffering from some acute and chronic neuroinfections (grave local forms of acute tick-borne encephalitis, progredient forms of the same encephalitis, disseminated sclerosis, disseminated encephalomyelitis). "
2.	Transplantation (Transplant Recipients) 01/01/2013 - "In this systematic review, we identify the serologic response rate of SOT recipients to post-transplantation vaccination against tetanus, diphtheria, polio, hepatitis A and B, influenza, Streptococcus pneumoniae, Haemophilus influenzae, Neisseria meningitides, tick-borne encephalitis, rabies, varicella, mumps, measles, and rubella. " 02/26/1999 - "Efficacy of vaccination against tick-borne encephalitis (TBE) using an abbreviated immunization schedule was compared in 31 heart transplant recipients (age: 54.5 +/- 11.5 years, mean time after transplantation: 53.5 +/- 23.7 months) under cyclosporine-based immunosuppression and 29 controls. "
3.	Aftercare (After-Treatment) 02/20/2014 - "[After-care in general practice after tick-borne encephalitis]." 01/01/2011 - "The aim of the study was to assess the concentration of chemokines: CXCL10, XCL11, CXCL12, CXCL13 in serum and cerebrospinal fluid (CSF) in patients with tick-borne encephalitis (TBE) before and after treatment. " 03/01/1999 - "Cerebrospinal fluid (CSF) serotonin was determined in 38 patients with pyogenic meningitis and tick-borne encephalitis (TBE) before and after treatment. " 05/01/1983 - "Electron microscopic studies of morphological lesions in pig embryo kidney cells (PEK) infected with tick-borne encephalitis (TBE) virus as well as morphology and features of TBE morphogenesis after treatment with actinomycin D, cycloheximide and hypertonic NaC1 concentrations in the medium were carried out. "
4.	Transplants (Transplant) 03/01/1980 - "The graft versus host reaction (GVHR) under conditions of two-way incompatibility was shown to increase average longevity (AL) of mice with experimental tick-borne encephalitis (TBE) and to activate asymptomatic infection caused by Langat virus. " 01/01/1986 - "Soluble autoantigens (mouse red blood cells lysed by sonication) blocked in vitro the antigen-recognizing receptors of tick-borne encephalitis (TBE) virus-induced autoreactive T-lymphocytes (ARTL), effectors of the local graft-versus-host reaction (GVHR) in a syngeneic system and prevented the development of GVHR in vivo. "
5.	Thymectomy 11/29/2010 - "Antibody dynamics after tick-borne encephalitis and measles-mumps-rubella vaccination in children post early thymectomy."