Acute Disseminated Encephalomyelitis (Postinfectious Encephalomyelitis)

An acute or subacute inflammatory process of the CENTRAL NERVOUS SYSTEM characterized histologically by multiple foci of perivascular demyelination. Symptom onset usually occurs several days after an acute viral infection or immunization, but it may coincide with the onset of infection or rarely no antecedent event can be identified. Clinical manifestations include CONFUSION, somnolence, FEVER, nuchal rigidity, and involuntary movements. The illness may progress to COMA and eventually be fatal. (Adams et al., Principles of Neurology, 6th ed, p921)
Also Known As:
Postinfectious Encephalomyelitis; Encephalomyelitis, Acute Disseminated; Disseminated Encephalomyelitis, Acute; Encephalitis, Postvaccinal; Encephalitis, Vaccination; Encephalomyelitis, Postexanthem; Encephalomyelitis, Postinfectious; Post-Vaccinal Encephalitis; Postexanthem Encephalomyelitis; Postvaccinal Encephalitis; Acute Disseminated Encephalomyelitides; Disseminated Encephalomyelitides, Acute; Encephalitides, Post-Vaccinal; Encephalitis, Post Vaccinal; Encephalomyelitides, Acute Disseminated; Encephalomyelitides, Post-Vaccinal; Encephalomyelitis, Post-Vaccinal; Post Vaccinal Encephalitis; Post Vaccinal Encephalomyelitis; Post-Vaccinal Encephalitides; Post-Vaccinal Encephalomyelitides; Encephalitis, Post-Vaccinal; Post-Vaccinal Encephalomyelitis; Vaccination Encephalitis
Networked: 268 relevant articles (4 outcomes, 9 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Encephalitis (Encephalitis, Rasmussen)
2. Optic Neuritis (Retrobulbar Neuritis)
3. Smallpox (Variola)
4. Neoplasms (Cancer)
5. Multiple Sclerosis


1. Dale, Russell C: 7 articles (01/2016 - 10/2005)
2. Rostasy, Kevin: 5 articles (12/2013 - 02/2007)
3. Banwell, Brenda: 5 articles (11/2013 - 02/2007)
4. Brilot, Fabienne: 4 articles (01/2016 - 12/2009)
5. Vincent, Angela: 4 articles (04/2015 - 04/2013)
6. Ichiyama, Takashi: 4 articles (01/2014 - 03/2002)
7. Reindl, Markus: 4 articles (12/2013 - 01/2011)
8. Dale, R C: 4 articles (08/2011 - 11/2001)
9. Hacohen, Yael: 3 articles (04/2015 - 04/2013)
10. Waters, Patrick: 3 articles (04/2015 - 11/2013)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Acute Disseminated Encephalomyelitis:
1. MethylprednisoloneFDA LinkGeneric
2. gamma-Globulins (gamma-Globulin)IBA
3. N-Methylaspartate (NMDA)IBA
02/01/2012 - "Anti-N-methyl-D-aspartate receptor encephalitis with acute disseminated encephalomyelitis-like MRI features."
03/01/2014 - "Three patients (2.2%) had serious PND including acute disseminated encephalomyelitis in 1 and anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis in 2. Although all of three improved after tumor removal, one without immunotherapy had neurological sequelae and prolonged ICU stay. "
04/01/2015 - "In descending order of frequency, the larger subgroups were acute disseminated encephalomyelitis (21%), enterovirus (12%), Mycoplasma pneumoniae (7%), N-methyl-D-aspartate receptor antibody (6%), herpes simplex virus (5%), and voltage-gated potassium channel complex antibody (4%). "
07/01/2015 - "The review also describes immune-mediated disorders, including acute disseminated encephalomyelitis and N-methyl-D-aspartate receptor antibody encephalitis, conditions that mimic virus encephalitis and account for a substantial proportion of childhood encephalitis. "
12/01/2014 - "The proposals include therapeutic plasma exchange (TPE) in neuromyelitis optica; TPE versus intravenous immunoglobulin (IVIG) in anti-muscle specific kinase associated myasthenia gravis, severe acute disseminated encephalomyelitis, and anti-NMDA encephalitis; extracorporeal photopheresis in relapsing remitting multiple sclerosis and polymyositis; fibrinogen/low-density lipoprotein apheresis in idiopathic sudden sensorineural hearing loss; and creation of a rare neurologic disease registry and biorepository. "
4. AnthelminticsIBA
5. AntibodiesIBA
6. oligodendrocyte-myelin glycoproteinIBA
7. AutoantibodiesIBA
8. GadoliniumIBA
9. Inosine Triphosphate (ITP)IBA
10. ArrestinIBA

Therapies and Procedures

1. Immunotherapy
2. Intensive Care (Surgical Intensive Care)
3. Plasmapheresis
4. Aftercare (After-Treatment)
5. Bone Marrow Transplantation (Transplantation, Bone Marrow)