Elephantiasis

10/23/1993 - "To study efficacy of treatment of filarial lymphoedema and elephantiasis with 5,6-benzo-alpha-pyrone. "
06/01/1996 - "2. Coumarin itself (1,2-benzopyrone) has long-established efficacy in slow-onset long-term reduction of lymphoedema in man, as confirmed in recent double-blind trials against elephantiasis and postmastectomy swelling of the arm. "
06/01/1993 - "Chronic filaritic lymphoedema and elephantiasis, in India, were treated orally with 5,6 benzo-alpha-pyrone (56 BaP; 1,2 benzo-alpha-pyrone; coumarin) in a double-blind, randomized, matched-group trial. "
10/23/1993 - "5,6-benzo-alpha-pyrone reduces the oedema and many symptoms of filarial lymphoedema and elephantiasis. "
10/23/1993 - "Treatment of filarial lymphoedema and elephantiasis with 5,6-benzo-alpha-pyrone (coumarin)."

12/01/1997 - "We could not confirm our earlier results and therefore concluded that HLA-DR and -DQ alleles are at least not strongly associated with progression to elephantiasis in Brugian filariasis. "
07/01/1989 - "There was, however, a significantly greater proportion (P less than 0.01) of 'activated' cytotoxic/suppressor lymphocytes (defined by co-expression of CD8 and HLA-DR) in patients with elephantiasis (16.4 +/- 8.6%) than in the MF (8.9 +/- 2.6%) or NV (8.3 +/- 2.9%) groups. "

06/01/1995 - "Production of interferon (IFN)-gamma by BmA-stimulated mononuclear cells increased significantly after DEC treatment (geometric mean, 39.6-55.7 U/mL; P < .05), largely due to improved responses in elephantiasis patients and asymptomatic amicrofilaremics. "

07/01/1989 - "There was, however, a significantly greater proportion (P less than 0.01) of 'activated' cytotoxic/suppressor lymphocytes (defined by co-expression of CD8 and HLA-DR) in patients with elephantiasis (16.4 +/- 8.6%) than in the MF (8.9 +/- 2.6%) or NV (8.3 +/- 2.9%) groups. "

06/01/1996 - "A spectacular improvement in the lesions, including disappearance of bacterial superinfections and of associated oedema and elephantiasis, was observed as soon as 2-4 months after the beginning of treatment. "

04/01/1998 - "Analysis of Western blot patterns showed an overall tendency for stronger IgG4 responses in microfilaraemic cases, and higher IgG1 responses in elephantiasis patients, consistent with published studies using ELISA on unfractionated parasite extracts. "
02/01/2003 - "gamma-GT-specific IgG1, rather than IgG4, was the predominant IgG subclass, particularly in patients with TPE (geomean, 6,321 ng/ml; range, 78 to 354,867 ng/ml) and was 75 times higher than in patients with elephantiasis (CP) (P < 0.003) and 185 times higher than in endemic normal individuals (ENL) (P < 0.010). "
04/01/2000 - "The IgG4 responses were significantly higher in early asymptomatic patients whether microfilaremic or amicrofilaremic than in hydrocele or in chronic elephantiasis (P < 0.05) & (P < 0.001) respectively. "
03/01/1998 - "Non-endemic normals, soil-transmitted helminth infected persons and chronic elephantiasis cases were negative for antifilarial IgG4 antibody. "
08/01/1978 - "In the presence of serum, or its immunoglobulin G fraction, from patients with elephantiasis, L. "

01/01/1999 - "Adverse reactions following diethylcarbamazine (DEC) intake in 'endemic normals', microfilaraemics and elephantiasis patients."
09/01/1981 - "The long term effects of repeated diethylcarbamazine administration with special reference to microfilaraemia and elephantiasis."
11/01/1978 - "Twenty-five years after the fight started against Wuchereria bancrofti var. pacifica in French Polynesia and which was based upon mass chimiotherapy by diethylcarbamazine (Banocide), a survey realized in 1975 and 1976 among 274 patients with elephantiasis allows us to give precise details of the local clinical and epidemiological aspects. "
07/01/1977 - "In one patient elephantiasis who died following diethylcarbamazine therapy there were large numbers of microfilariae of Onchocerca volvulus in the kidney, liver, pancreas, and lung. "
11/01/1999 - "In an earlier study in Indonesia we reported on adverse reactions to diethylcarbamazine (DEC) in brugian filariasis patients identified as microfilaraemics (n = 26), endemic normals (n = 11) and elephantiasis patients (n = 17). "

01/01/1998 - "Both anti-L3 surface and somatic antibodies are strongest in elephantiasis patients, and tend to increase with age. "
12/01/1989 - "To evaluate the amount and character of the filaria-specific antibodies in the lungs in this disorder, bronchoalveolar lavage was carried out in individuals with acute TPE, in normal subjects, and in patients with elephantiasis or asthma. "
09/29/1998 - "An antigenic band with the MW of approximately 37 kDa was found to be consistently present in the Western blots of all microfilaraemic sera, all amicrofilaraemic sera with high titres of anti-filarial IgG4 antibodies, some treated patients, and some elephantiasis patients. "
09/29/1998 - "Western blot analyses were performed on 444 serum specimens: 40 sera from microfilaraemic individuals, 10 sera from elephantiasis patients, 24 treated individuals, 50 sera from residents of endemic areas without anti-filarial IgG4 antibodies (endemic normals), 20 sera from amicrofilaraemic individuals with high anti-filarial IgG4 antibodies, 200 sera from healthy city-dwellers (non-endemic samples), and 100 sera from soil-transmitted helminth-infected individuals. "
12/01/1995 - "IgG1 levels declined in a less consistent and extreme manner, and levels of IgG2 and IgG3 declined only in patients with elephantiasis, who also had the highest initial levels of these antibodies. "

01/01/1966 - "[Study of the proteins in blood and interstitial fluid of patients with lymphedema and elephantiasis. "

06/01/1975 - "The results of the study showed that (1) there is great variation in gold disappearance rates in different cats in all 3 groups above, (2) the cat lymphatic system is functionally highly efficient, and (3) in a cat with lymphoedema and early elephantiasis, there was a significant impairment of gold removal from the affected foot. "

01/01/1969 - "[Study of the skin in elephantiasis for the determination of its suitability for transplantation]."
02/01/2014 - "Double autologous lymph node transplantation (ALNT) at the level of the knee and inguinal region for advanced lymphoedema of the lower limb (elephantiasis)."
06/01/2006 - "From 1988 to 2005, 8 men who presented with penoscrotal elephantiasis underwent penile shaft degloving and reduction scrotoplasty, followed by transplantation of a split-thickness skin graft (STSG) to the penile shaft. "
01/01/1977 - "Only the lymphovenous shunts or lymphadenovenous shunts may be indicated in stage II. In the irreversible lymphoedema (stage III) and in the elephantiasis (stage IV) the following operations have been developed: ligature of ectatic lymphtrunks, peripheral lymphovenous and lymphadenovenous shunts, skin-flap transplantations, free or pediculated transplantation of the greater omentum, lymphangioplastic operations (Thompson-operation) or excisional operations (Servelle-operation). "

03/01/2009 - "Under the diagnosis of penile elephantiasis, the resection of abnormal penile skin and penile plasty with the split skin graft from his thigh was performed. "
12/01/1989 - "A case of left facial elephantiasis neurofibromatosa was treated with near-total excision and skin graft. "
12/01/1989 - "Facial elephantiasis neurofibromatosa--excision and skin graft."
04/01/1969 - "Results obtained with Gibson's operation (ablation of pathological tissue followed by dermo-epidermal grafts) in the treatment of elephantiasis of the lower extremities."
04/01/1953 - "[Elephantiasis of the legs; treatment by dermofibrolipectomy followed by free skin grafts]."

05/01/1976 - "From 1960 to date, there have been four cases of elephantiasis penis in the urologic clinic of the Katharinenhospital in Stuttgart, which were operated on by skin transplantation. "
05/01/1976 - "[Operative therapy of elephantiasis penis by skin transplantation (author's transl)]."
01/01/1964 - "[SKIN TRANSPLANTATION FOR ELEPHANTIASIS OF THE LOWER LIMBS]."
10/01/1951 - "[Elephantiasis of the lower extremities; treatment by dermofibrolipectomy followed by free skin grafting]."
12/01/1946 - "A case of elephantiasis treated by primary skin-grafting."

04/01/2008 - "In cases of irreversible penoscrotal elephantiasis, excision and amputation of the affected penoscrotal areas are recommended to eliminate the functional disturbances. "
01/01/1954 - "[Explication of the pathogenesis of elephantiasis after amputation of the mamma]."
10/01/2008 - "In this report, we present a patient who was treated by below knee amputation as a result of elephantiasis nostras verrucosa complicated with chronic tibial osteomyelitis."
08/01/1985 - "The combination of drug injection trauma and Graves' dermopathy produced elephantiasis-like appearance of upper and lower limbs with impairment of their function; the left hand required amputation. "
04/01/2003 - "The different complications were: urethral fistulas (n = 41), total or partial glans amputation (n = 9), urethral stricture of the meatus (n = 8), penile pseudo elephantiasis (n = 2), penile denudation (n = 1), hemorragiae (n = 6) and septicaemia (n = 1). "

11/01/1999 - "In microfilaraemics the levels of sTNF-R75 increased after treatment to reach levels recorded in elephantiasis patients. "
11/01/1933 - "Elephantiasis twelve years after treatment by Kondoleon's Operation."
01/01/1922 - "Case of Elephantiasis exhibited Eleven Months after Treatment by Kondoleon's Operation."
11/01/1998 - "[A case of scrotal elephantiasis 30 years after treatment of penile carcinoma]."