Ehlers-Danlos Syndrome (Syndrome, Ehlers-Danlos)

A heterogeneous group of autosomally inherited COLLAGEN DISEASES caused by defects in the synthesis or structure of FIBRILLAR COLLAGEN. There are numerous subtypes: classical, hypermobility, vascular, and others. Common clinical features include hyperextensible skin and joints, skin fragility and reduced wound healing capability.

Also Known As:

Syndrome, Ehlers-Danlos; Ehlers Danlos Disease; Ehlers-Danlos Disease; Danlos Disease, Ehlers; Disease, Ehlers Danlos; Disease, Ehlers-Danlos; Ehlers Danlos Syndrome; Cutis Elastica

Networked: 799 relevant articles (8 outcomes, 32 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Chronic Pain
2.	Anxiety Disorders (Anxiety Disorder)
3.	Joint Instability (Joint Laxity)
4.	Postural Orthostatic Tachycardia Syndrome
5.	Obstructive Sleep Apnea

Experts

1.	Malfait, Fransiska: 20 articles (05/2022 - 10/2004)
2.	Kosho, Tomoki: 18 articles (09/2022 - 02/2007)
3.	Colombi, Marina: 13 articles (11/2021 - 04/2004)
4.	Birk, David E: 13 articles (01/2021 - 09/2002)
5.	De Paepe, Anne: 13 articles (01/2018 - 04/2004)
6.	Mizumoto, Shuji: 12 articles (07/2022 - 09/2013)
7.	Giunta, Cecilia: 12 articles (01/2021 - 03/2005)
8.	Yamada, Shuhei: 11 articles (07/2022 - 01/2015)
9.	Symoens, Sofie: 11 articles (10/2021 - 04/2007)
10.	Zoppi, Nicoletta: 10 articles (11/2021 - 04/2004)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Ehlers-Danlos Syndrome:

1.	CollagenIBA 11/01/1985 - "The light emission measurements obtained showed a statistically significant reduction in the dermal collagen density of Ehlers-Danlos syndrome patients as compared to their controls. " 02/06/2016 - "Reduction of collagen V expression, such as in classic Ehlers-Danlos syndrome, results in altered fibril morphology and altered macroscale mechanical function in both clinical and animal studies, yet the mechanism by which changes at the fibril level lead to macroscale functional changes has not yet been investigated. " 10/01/2013 - "In the current study, we investigated proprioceptive acuity and proprioceptive recalibration in a group of individuals with Ehlers-Danlos syndrome (EDS), a degenerative condition associated with collagen malformation. " 05/01/2000 - "The ultrastructural and histophotometric study of elastic and collagen fibers in type II Ehlers-Danlos syndrome and subclinical forms." 11/01/1993 - "A morphometric ultrastructural study was performed to confirm the presence of an abnormality of the collagen fibrils in a rabbit with a connective tissue defect similar to Ehlers-Danlos syndrome. "
2.	Risperidone (Risperdal Consta)FDA LinkGeneric 07/31/2020 - "Risperidone for the Management of Treatment-Resistant Anxiety in a Patient with Ehlers-Danlos Syndrome: A Case Report." 07/31/2020 - "Patients with Ehlers-Danlos syndrome (EDS) have a higher prevalence of comorbid anxiety disorders. Due to the complex nature of these patients, there is often a delay in the diagnosis of these disorders as well as insufficient management of their anxiety symptoms. Current treatment options are often insufficient or poorly tolerated by patients, creating barriers to proper treatment. We hypothesized that patients with EDS and comorbid anxiety, who have failed multiple medication trials, may benefit from a trial of risperidone. In this case report, we discuss the successful management of treatment-resistant anxiety in a patient with EDS with the use of risperidone. Management of comorbid anxiety in these patients is essential, as untreated anxiety can result in increased somatic sensation sensitivity and poor social functioning. Once underlying anxiety disorders are addressed, patients with EDS can better cope with chronic pain symptoms and are more likely to build a therapeutic alliance with their treating physicians. This results in an improved prognosis, social functioning, and overall quality of life."
3.	Ascorbic Acid (Vitamin C)FDA LinkGeneric 01/01/2020 - "Fibroblasts from patients with osteogenesis imperfecta and Ehlers Danlos syndrome were cultured with ascorbic acid for 5 weeks. " 03/01/1982 - "Genetic impairment of collagen synthesis has also been observed to be responsive to ascorbic acid supplementation in an 8-year-old boy with Type VI Ehlers-Danlos syndrome. " 01/01/2005 - "We therefore hypothesize that the symptoms associated with Ehlers-Danlos syndrome may be successfully alleviated using a specific (and potentially synergistic) combination of nutritional supplements, comprising calcium, carnitine, coenzyme Q(10), glucosamine, magnesium, methyl sulphonyl methane, pycnogenol, silica, vitamin C, and vitamin K, at dosages which have previously been demonstrated to be effective against the above symptoms in other disorders."
4.	VitaminsIBA 01/01/1976 - "[Efficacy of prolonged therapy with vitamins C and A and radiologic changes in the Ehlers-Danlos syndrome]." 03/01/1991 - "[Excretion of pyridinoline with urine in children with Ehlers-Danlos syndrome and Marfan's syndrome and the effect of beta blocker and complex vitamin therapy on it]."
5.	Doxycycline (Periostat)FDA LinkGeneric 06/01/2011 - "Doxycycline ameliorates the susceptibility to aortic lesions in a mouse model for the vascular type of Ehlers-Danlos syndrome." 11/19/2021 - "Matrix Metalloproteinases Inhibition by Doxycycline Rescues Extracellular Matrix Organization and Partly Reverts Myofibroblast Differentiation in Hypermobile Ehlers-Danlos Syndrome Dermal Fibroblasts: A Potential Therapeutic Target?"
6.	Vitamin K FDA Link 01/01/2005 - "We therefore hypothesize that the symptoms associated with Ehlers-Danlos syndrome may be successfully alleviated using a specific (and potentially synergistic) combination of nutritional supplements, comprising calcium, carnitine, coenzyme Q(10), glucosamine, magnesium, methyl sulphonyl methane, pycnogenol, silica, vitamin C, and vitamin K, at dosages which have previously been demonstrated to be effective against the above symptoms in other disorders."
7.	UbiquinoneIBA 01/01/2005 - "We therefore hypothesize that the symptoms associated with Ehlers-Danlos syndrome may be successfully alleviated using a specific (and potentially synergistic) combination of nutritional supplements, comprising calcium, carnitine, coenzyme Q(10), glucosamine, magnesium, methyl sulphonyl methane, pycnogenol, silica, vitamin C, and vitamin K, at dosages which have previously been demonstrated to be effective against the above symptoms in other disorders."
8.	Tramadol (K315)FDA LinkGeneric 01/01/2004 - "Tramadol hydrochloride was a safe and effective treatment for relieving chronic pain in two pediatric patients suffering from the hypermobility type of Ehlers-Danlos syndrome. "
9.	Silicon Dioxide (Silica)FDA LinkGeneric 01/01/2005 - "We therefore hypothesize that the symptoms associated with Ehlers-Danlos syndrome may be successfully alleviated using a specific (and potentially synergistic) combination of nutritional supplements, comprising calcium, carnitine, coenzyme Q(10), glucosamine, magnesium, methyl sulphonyl methane, pycnogenol, silica, vitamin C, and vitamin K, at dosages which have previously been demonstrated to be effective against the above symptoms in other disorders."
10.	MagnesiumIBA 01/01/2005 - "We therefore hypothesize that the symptoms associated with Ehlers-Danlos syndrome may be successfully alleviated using a specific (and potentially synergistic) combination of nutritional supplements, comprising calcium, carnitine, coenzyme Q(10), glucosamine, magnesium, methyl sulphonyl methane, pycnogenol, silica, vitamin C, and vitamin K, at dosages which have previously been demonstrated to be effective against the above symptoms in other disorders."

Therapies and Procedures

1.	Therapeutics 02/01/2008 - "Further studies are warranted on endovascular repair therapy for artery complication of Ehlers-Danlos syndrome." 05/05/2021 - "Gnathological and osteopathic treatments with digital evalua- tions before and after therapies: a case report of a patient with ehlers-danlos syndrome." 01/01/2018 - "There is very limited evidence to guide the use of physical and mechanical therapies for lower limb problems in children with Hypermobility Spectrum Disorder and Hypermobile Ehlers Danlos Syndrome. " 01/01/2018 - "Physical and mechanical therapies for lower limb symptoms in children with Hypermobility Spectrum Disorder and Hypermobile Ehlers-Danlos Syndrome: a systematic review." 04/01/2001 - "These data suggest the feasibility of gene replacement therapy to modify skin wound healing in type VI Ehlers-Danlos syndrome patients."
2.	Laser In Situ Keratomileusis (LASIK) 03/01/2023 - "The purpose of this study was to determine the safety and outcomes of myopic laser in situ keratomileusis (LASIK) in patients who were secondarily diagnosed with hypermobile Ehlers-Danlos syndrome (EDS). " 03/01/2023 - "Outcomes and Complications in Patients With Hypermobile Ehlers-Danlos Syndrome Who Have Undergone Laser In Situ Keratomileusis Surgery." 09/01/2020 - "We describe the first case of Ehlers Danlos Syndrome (EDS) reported in the English language ophthalmic literature to have undergone Laser In Situ Keratomileusis (LASIK) surgery. " 09/01/2020 - "Myopic regression and recurrent Salzmann nodule degeneration after laser in situ keratomileusis in Ehlers Danlos Syndrome."
3.	Complementary Therapies (Alternative Medicine) 01/01/2022 - "Use of complementary and alternative medicine by patients with hypermobile Ehlers-Danlos Syndrome: A qualitative study." 11/01/2020 - "Use of complementary therapies for chronic pain management in patients with reported Ehlers-Danlos syndrome or hypermobility spectrum disorders."
4.	Diskectomy (Discectomy) 01/16/2023 - "To study postoperative complication rates following anterior cervical discectomy and fusion (ACDF) in patients with Ehlers-Danlos syndrome (EDS) compared with patients without EDS. " 01/16/2023 - "Outcomes Following Anterior Cervical Discectomy and Fusion in Patients With Ehlers-Danlos Syndrome."
5.	Anesthesia 07/23/2014 - "Recommendations for anesthesia and perioperative management in patients with Ehlers-Danlos syndrome(s)." 01/01/2007 - "After completion of this article, the reader should be able to recall the potentially severe nature of Ehlers-Danlos Syndrome (EDS) in both pregnant and nonpregnant patients, summarize the wide range of signs and symptoms and its genetic inheritance, and explain the difficulty in recommending obstetric and anesthesia procedures to avoid complications." 10/01/2002 - "[Anesthesia considerations in Ehlers-Danlos syndrome]." 11/01/1986 - "[Anesthesia in Ehlers-Danlos syndrome]." 08/01/1984 - "[A case report of anesthesia in a shocked obstetric patient complicated with Ehlers-Danlos syndrome]."