Ehlers-Danlos Syndrome (Syndrome, Ehlers-Danlos)

A heterogeneous group of autosomally inherited COLLAGEN DISEASES caused by defects in the synthesis or structure of FIBRILLAR COLLAGEN. There are numerous subtypes: classical, hypermobility, vascular, and others. Common clinical features include hyperextensible skin and joints, skin fragility and reduced wound healing capability.

Also Known As:

Networked: 722 relevant articles (5 outcomes, 40 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Varicose Veins (Varicose Vein)
2.	Pain (Aches)
3.	Osteogenesis Imperfecta (Lobstein Disease)
4.	Cutis Laxa
5.	Ehlers-Danlos Syndrome (Syndrome, Ehlers-Danlos)

Experts

1.	De Paepe, Anne: 13 articles (05/2015 - 04/2004)
2.	Malfait, Fransiska: 12 articles (05/2015 - 10/2004)
3.	Birk, David E: 9 articles (06/2015 - 09/2002)
4.	Hausser, Ingrid: 8 articles (05/2015 - 10/2004)
5.	Giunta, Cecilia: 8 articles (12/2012 - 01/2004)
6.	Steinmann, Beat: 8 articles (12/2012 - 07/2002)
7.	Schalkwijk, J: 8 articles (10/2011 - 10/2001)
8.	Symoens, Sofie: 7 articles (05/2015 - 05/2005)
9.	Schalkwijk, Joost: 7 articles (08/2013 - 04/2004)
10.	Byers, Peter H: 6 articles (06/2015 - 05/2004)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Ehlers-Danlos Syndrome:

1.	CollagenIBA 11/01/1985 - "The light emission measurements obtained showed a statistically significant reduction in the dermal collagen density of Ehlers-Danlos syndrome patients as compared to their controls. " 10/01/2013 - "In the current study, we investigated proprioceptive acuity and proprioceptive recalibration in a group of individuals with Ehlers-Danlos syndrome (EDS), a degenerative condition associated with collagen malformation. " 05/01/2000 - "The ultrastructural and histophotometric study of elastic and collagen fibers in type II Ehlers-Danlos syndrome and subclinical forms." 12/01/1996 - "Pulmonary complications are described in a case of Ehlers-Danlos syndrome type IV, established by studies of collagen biosynthesis. " 07/01/1995 - "A sporadic case of Ehlers-Danlos syndrome type IV: diagnosed by a morphometric study of collagen content."
2.	Ascorbic Acid (Vitamin C)FDA LinkGeneric 03/01/1989 - "The uptake of ascorbic acid by cultured skin fibroblasts from two siblings with Ehlers-Danlos syndrome type VI, in extracts of which there is no deficit in lysyl hydroxylase activity, was found to be normal. " 03/01/1989 - "Ehlers-Danlos syndrome type VI with normal lysyl hydroxylase activity cannot be explained by a defect in cellular uptake of ascorbic acid." 03/01/1982 - "Genetic impairment of collagen synthesis has also been observed to be responsive to ascorbic acid supplementation in an 8-year-old boy with Type VI Ehlers-Danlos syndrome. " 01/01/2005 - "We therefore hypothesize that the symptoms associated with Ehlers-Danlos syndrome may be successfully alleviated using a specific (and potentially synergistic) combination of nutritional supplements, comprising calcium, carnitine, coenzyme Q(10), glucosamine, magnesium, methyl sulphonyl methane, pycnogenol, silica, vitamin C, and vitamin K, at dosages which have previously been demonstrated to be effective against the above symptoms in other disorders."
3.	Doxycycline (Vibramycin)FDA LinkGeneric 06/01/2011 - "Doxycycline ameliorates the susceptibility to aortic lesions in a mouse model for the vascular type of Ehlers-Danlos syndrome." 10/01/2012 - "Chronic treatment with a broad-spectrum metalloproteinase inhibitor, doxycycline, prevents the development of spontaneous aortic lesions in a mouse model of vascular Ehlers-Danlos syndrome."
4.	Vitamin KFDA Link 01/01/2005 - "We therefore hypothesize that the symptoms associated with Ehlers-Danlos syndrome may be successfully alleviated using a specific (and potentially synergistic) combination of nutritional supplements, comprising calcium, carnitine, coenzyme Q(10), glucosamine, magnesium, methyl sulphonyl methane, pycnogenol, silica, vitamin C, and vitamin K, at dosages which have previously been demonstrated to be effective against the above symptoms in other disorders."
5.	UbiquinoneIBA 01/01/2005 - "We therefore hypothesize that the symptoms associated with Ehlers-Danlos syndrome may be successfully alleviated using a specific (and potentially synergistic) combination of nutritional supplements, comprising calcium, carnitine, coenzyme Q(10), glucosamine, magnesium, methyl sulphonyl methane, pycnogenol, silica, vitamin C, and vitamin K, at dosages which have previously been demonstrated to be effective against the above symptoms in other disorders."
6.	TramadolFDA LinkGeneric 01/01/2004 - "Tramadol hydrochloride was a safe and effective treatment for relieving chronic pain in two pediatric patients suffering from the hypermobility type of Ehlers-Danlos syndrome. " 01/01/2004 - "Tramadol hydrochloride was administered (50 mg/day to 150 mg/day) to two siblings with Ehlers-Danlos syndrome - Hypermobility type refractory to previous pharmacological treatments, and changes in pain intensity and physical activity were assessed. " 01/01/2004 - "Treatment of pediatric chronic pain with tramadol hydrochloride: siblings with Ehlers-Danlos syndrome - Hypermobility type."
7.	Silicon Dioxide (Sand)FDA LinkGeneric 01/01/2005 - "We therefore hypothesize that the symptoms associated with Ehlers-Danlos syndrome may be successfully alleviated using a specific (and potentially synergistic) combination of nutritional supplements, comprising calcium, carnitine, coenzyme Q(10), glucosamine, magnesium, methyl sulphonyl methane, pycnogenol, silica, vitamin C, and vitamin K, at dosages which have previously been demonstrated to be effective against the above symptoms in other disorders."
8.	MagnesiumIBA 01/01/2005 - "We therefore hypothesize that the symptoms associated with Ehlers-Danlos syndrome may be successfully alleviated using a specific (and potentially synergistic) combination of nutritional supplements, comprising calcium, carnitine, coenzyme Q(10), glucosamine, magnesium, methyl sulphonyl methane, pycnogenol, silica, vitamin C, and vitamin K, at dosages which have previously been demonstrated to be effective against the above symptoms in other disorders."
9.	Glucosamine (Dona)IBA 01/01/2005 - "We therefore hypothesize that the symptoms associated with Ehlers-Danlos syndrome may be successfully alleviated using a specific (and potentially synergistic) combination of nutritional supplements, comprising calcium, carnitine, coenzyme Q(10), glucosamine, magnesium, methyl sulphonyl methane, pycnogenol, silica, vitamin C, and vitamin K, at dosages which have previously been demonstrated to be effective against the above symptoms in other disorders."
10.	Carnitine (L-Carnitine)FDA LinkGeneric 01/01/2005 - "We therefore hypothesize that the symptoms associated with Ehlers-Danlos syndrome may be successfully alleviated using a specific (and potentially synergistic) combination of nutritional supplements, comprising calcium, carnitine, coenzyme Q(10), glucosamine, magnesium, methyl sulphonyl methane, pycnogenol, silica, vitamin C, and vitamin K, at dosages which have previously been demonstrated to be effective against the above symptoms in other disorders."

Therapies and Procedures

1.	Laser Therapy (Surgery, Laser) 08/01/2015 - "Open varicose vein surgery has been reported as being hazardous in the past in a patient with Ehlers Danlos syndrome type IV. Our experience has shown that endovenous laser ablation, transluminal occlusion of perforator and ultrasound guided foam sclerotherapy appear to be effective in treating this patient with Ehlers Danlos syndrome type IV, although phlebectomies were technically impossible. " 08/01/2015 - "She was subsequently diagnosed as Ehlers Danlos syndrome type IV. A duplex ultrasound scan 18 months post-endovenous laser ablation and transluminal occlusion of perforator and 11 months after ultrasound guided foam sclerotherapy confirmed successful closure with virtual atrophy of all treated veins. "
2.	Sclerotherapy 08/01/2015 - "Open varicose vein surgery has been reported as being hazardous in the past in a patient with Ehlers Danlos syndrome type IV. Our experience has shown that endovenous laser ablation, transluminal occlusion of perforator and ultrasound guided foam sclerotherapy appear to be effective in treating this patient with Ehlers Danlos syndrome type IV, although phlebectomies were technically impossible. " 08/01/2015 - "She was subsequently diagnosed as Ehlers Danlos syndrome type IV. A duplex ultrasound scan 18 months post-endovenous laser ablation and transluminal occlusion of perforator and 11 months after ultrasound guided foam sclerotherapy confirmed successful closure with virtual atrophy of all treated veins. "
3.	Anesthesia 01/01/2014 - "Recommendations for anesthesia and perioperative management in patients with Ehlers-Danlos syndrome(s)." 05/01/2008 - "[Management of anesthesia in vascular-type Ehlers-Danlos syndrome (type IV)]." 01/01/2007 - "After completion of this article, the reader should be able to recall the potentially severe nature of Ehlers-Danlos Syndrome (EDS) in both pregnant and nonpregnant patients, summarize the wide range of signs and symptoms and its genetic inheritance, and explain the difficulty in recommending obstetric and anesthesia procedures to avoid complications." 10/01/2002 - "[Anesthesia considerations in Ehlers-Danlos syndrome]." 05/01/1997 - "Anesthesia for cesarean delivery in a patient with Ehlers-Danlos syndrome type II."
4.	Transplants (Transplant) 10/01/2015 - "To our knowledge, this is the first report of a heart transplant performed in an individual with Ehlers-Danlos syndrome. " 07/01/1957 - "The behavior of skin grafts and donor sites in a case of Ehlers-Danlos Syndrome." 11/01/2011 - "In this case report we describe a spontaneous left anterior descending coronary artery dissection treated with coronary artery bypass graft in a patient with Ehlers-Danlos syndrome type IV." 04/01/1997 - "Vestibuloplasty with a split thickness skin graft in a patient with Ehlers-Danlos syndrome." 07/01/2007 - "Case 2; A female with Ehlers-Danlos syndrome had undergone resection of descending aortic thoracic aneurysm presented with an enlarging aneurysm distal to the graft. "
5.	Cesarean Section (Caesarean Section) 04/01/2011 - "A double-bubble sign was detected by ultrasonography in a GII, PII, who suffers from Ehlers-Danlos syndrome type II. The delivery was done by Caesarean section based on the suspicion of premature placental separation. " 10/01/2009 - "There have been several reports of resistance to local anaesthetic agents in women with Ehlers-Danlos syndrome, hypermobility type, also known as Ehlers-Danlos syndrome Type III. General anaesthesia with rapid sequence induction was performed for caesarean section due to prolonged second stage of labour, but intubation proved to be difficult. " 11/01/1992 - "Anaesthesia for caesarean section in a patient with Ehlers-Danlos syndrome type IV." 06/01/1981 - "Tyson (1972) suggested that delivery by cesarean section was indicated in all cases of Ehlers-Danlos syndrome, but this pertains to the severe forms of the syndrome. " 05/01/2004 - "[Subarachnoid anesthesia for cesarean section in a patient with Ehlers-Danlos syndrome type II]."