Edrophonium (Tensilon)

A rapid-onset, short-acting cholinesterase inhibitor used in cardiac arrhythmias and in the diagnosis of myasthenia gravis. It has also been used as an antidote to curare principles.

Also Known As:

Networked: 326 relevant articles (26 outcomes, 37 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Goldstein, David S: 3 articles (05/2015 - 10/2004)
2.	Imrich, Richard: 2 articles (05/2015 - 09/2008)
3.	Wallace, M: 2 articles (08/2011 - 01/2010)
4.	Browning, J: 2 articles (08/2011 - 01/2010)
5.	Chana, J: 2 articles (08/2011 - 01/2010)
6.	Booth, J: 2 articles (08/2011 - 01/2010)
7.	Konishi, Tetsuro: 2 articles (07/2011 - 10/2009)
8.	Benatar, Michael: 2 articles (02/2010 - 07/2006)
9.	Kusunoki, Susumu: 2 articles (07/2009 - 07/2006)
10.	Shioyama, Mitsuaki: 2 articles (07/2009 - 07/2006)

Related Diseases

1.	Myasthenia Gravis 10/01/1988 - "The ptosis clinically resembled myasthenia gravis and improved after intravenous edrophonium. " 05/01/1992 - "In addition this case highlights the false-positive results that may occur with the edrophonium chloride test for myasthenia gravis." 01/01/1979 - "Myasthenia gravis: lung-function studies without and with edrophonium chloride." 01/01/2013 - "We review six patients who presented with only DHS, responded to intravenous edrophonium and turned out to have myasthenia gravis (MG) including similar patients who were previously documented. " 01/01/2013 - "Dropped head with positive intravenous edrophonium, progressing to myasthenia gravis."
2.	Muscle Weakness 01/01/2010 - "Intravenous edrophonium almost completely abolished the nystagmus and adducting muscle weakness, and improved the strength of proximal muscles groups. " 07/01/1990 - "On admission in August, 1988, Gowers' sign, decreased tendon reflexes and muscle weakness improved by the injection of edrophonium were found. " 01/01/2013 - "We examined sex, familiarity, age of onset, clinical symptoms, and response to tensilon test, patellar and pupillary reflexes, presence of cranial nerve involvement, Gowers' sign, presence of ptosis, grade of muscular weakness, and response to the treatment and gene deletions. " 04/01/2001 - "Preoperative assessment included clinical evaluation of muscle weakness, edrophonium testing, electromyography, lung function testing, chest X-rays and CAT scans. " 07/01/1996 - "An edrophonium test was positive: muscle weakness was transiently alleviated. "
3.	Chest Pain (Chest Pains) 07/01/1985 - "Edrophonium increased esophageal amplitude and repetitive contractions to a similar degree in all subjects, but the change in duration (101 +/- 13% [SE] was significantly greater (p less than 0.02) in patients in whom chest pain was induced. " 05/01/1997 - "CO2 inhalation is as effective as Tensilon in provoking chest pain in patients with noncardiac chest pain. " 05/01/2003 - "Stationary manometry, edrophonium testing, and ambulatory pH and motility studies were performed in 90 consecutive patients with recurrent chest pain and normal coronary angiograms. " 08/01/1990 - "The absence of patient selection and, possibly, the exclusion of biasing during the edrophonium tests are considered to be the most important factors for the finding of only few patients with definite esophagus-related noncardiac chest pain in this study. " 07/01/1987 - "Our aims were to: evaluate consecutively a large group of patients with proven noncardiac chest pain and normal baseline manometric studies, using edrophonium chloride, 10 mg, and determine the value of provocative testing in clinical practice. "
4.	Pain (Aches) 05/01/1992 - "Edrophonium, however, resulted in a significant reduction in distension threshold for pain (p less than 0.03) in patients. " 08/01/1992 - "Since the nature of this pain is intermittent and rarely present during the diagnostic study, acid perfusion and intravenous edrophonium tests were added as provocative tests after baseline esophageal manometry. " 03/01/1991 - "The aim of this study was to compare the most current tests used for the diagnosis of esophageal angina-like pain: manometry, balloon distension, edrophonium provocation. " 04/01/1988 - "A series of additional esophageal tests--motility studies, Bernstein test, edrophonium test, and balloon distention test--may be performed to help ascertain whether the pain stems from the esophagus. " 05/01/1997 - "Of 14 patients, 5 had pain with Tensilon (4 of 5 whom responded to CO2). "
5.	Paralysis (Palsy) 05/01/1982 - "Peripheral nerve stimulation indicated partial paralysis which improved promptly following a test dose of edrophonium. " 11/01/1995 - "However, durations decreased in myasthenia but increased in nonmyasthenic palsies after edrophonium. " 10/01/1994 - "Effects of edrophonium on saccadic velocity in normal subjects and myasthenic and nonmyasthenic ocular palsies." 07/01/1989 - "Tensilon given at 2 h was significantly more effective than antivenom at increasing the duration of upward gaze (78 +/- 28 vs 43 +/- 26 sec, P less than 0.001), and either completely reversed or markedly decreased paralysis in every patient. " 12/01/1977 - "In doubtful cases of eye muscle palsies the electromyogram of the affected muscle in connection with the Edrophonium-test is extremely valuable. "

Related Drugs and Biologics

1.	Acetylcholine (Acetylcholine Chloride)
2.	Edrophonium (Tensilon)
3.	Antibodies
4.	Pyridostigmine Bromide (Pyridostigmine)
5.	Cholinesterase Inhibitors (Anticholinesterases)
6.	musk
7.	Protein-Tyrosine Kinases (Tyrosine Kinase)
8.	Neostigmine (Neostigmine Bromide)
9.	Cholinesterases (Cholinesterase)
10.	Pancuronium (Pavulon)

Related Therapies and Procedures

1.	Intravenous Injections
2.	Vagus Nerve Stimulation
3.	Transplants (Transplant)
4.	Transplantation (Transplant Recipients)
5.	Massage (Reflexology)