Cardiac Edema

Abnormal fluid retention by the body due to impaired cardiac function or heart failure. It is usually characterized by increase in venous and capillary pressure, and swollen legs when standing. It is different from the generalized edema caused by renal dysfunction (NEPHROTIC SYNDROME).

Also Known As:

Networked: 107 relevant articles (2 outcomes, 4 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Pulmonary Hypertension (Ayerza Syndrome)
2.	Lung Injury
3.	Heart Failure
4.	Anoxia (Hypoxia)
5.	Cardiac Arrhythmias (Arrythmia)

Experts

1.	Madias, John E: 1 article (01/2016)
2.	Muenke, Maximilian: 1 article (09/2015)
3.	Mutesa, Leon: 1 article (09/2015)
4.	Hong, Sung-Kook: 1 article (09/2015)
5.	Kruszka, Paul: 1 article (09/2015)
6.	Chung, Brian: 1 article (09/2015)
7.	Mullikin, James C: 1 article (09/2015)
8.	Zackai, Elaine H: 1 article (09/2015)
9.	Ganetzky, Rebecca: 1 article (09/2015)
10.	Martinez, Ariel F: 1 article (09/2015)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Cardiac Edema:

1.	DiureticsIBA 01/31/1970 - "Diuretics in cardiac edema." 10/04/1969 - "New and powerful diuretics have made it possible for the physician to control cardiac edema in most patients. " 06/25/1961 - "[Treatment of cardiac edemas with the new diuretics]." 05/31/1960 - "[Pathogenesis of cardiac edema and its treatment with diuretics]." 07/26/1958 - "[Triazine compounds as diuretics in cardiac edemas]."
2.	tezosentanIBA 03/01/2004 - "These changes were attenuated by tezosentan infused at 1 and 2 mg x kg x hr. In an ovine model of endotoxin-induced lung injury, tezosentan ameliorates pulmonary hypertension, lung edema, cardiac dysfunction, and arterial hypoxemia. "
3.	Prednisone (Sone)FDA LinkGeneric 02/15/1959 - "Reversal of intractable cardiac edema with prednisone." 02/14/1959 - "[Increase of diuresis by prednisone in cardiac edema]." 01/01/1959 - "[Prednisone therapy of cardiac edema]." 01/01/1959 - "Reversal of intractable cardiac edema with prednisone (meticorten)." 06/01/1956 - "The effect of prednisone in the treatment of refractory cardiac edema."
4.	PotassiumIBA 11/12/1955 - "[Therapeutic studies with a new potassium diuretic in cardiac edema]." 08/01/1953 - "[Diuretic action of potassium associated with low sodium diet in treatment of cardiac edema; first results]." 09/15/1977 - "[Effects of a potassium-sparing diuretic in cardiac edema and ascitic cirrhosis]."
5.	CortisoneIBA 12/01/1958 - "[Cortisone preparations in refractory cardiac edema]." 01/01/1960 - "[Trial treatment of cardiac edema with cortisone and prednisone]." 12/01/1955 - "[ACTH and cortisone in refractory cardiac edema; physiopathological aspects in cardiac insufficiency]."
6.	mercaptomerinIBA 11/01/1952 - "[Trial of a new mercurial diuretic, thiomerin, in treatment of cardiac edema]." 05/01/1950 - "The treatment of cardiac edema with thiomerin sodium (mercaptomerin sodium)."
7.	Hexamethonium (Hexamethonium Bromide)IBA 08/01/1955 - "The lymphatic system, with particular reference to cardiac edema; an experimental study of the lymphodynamic effects of hexamethonium."
8.	SodiumIBA 02/10/1957 - "[The biological mechanism of sodium retention and its significance for the pathogenesis of cardiac edema]." 10/30/1956 - "[Biological mechanism of sodium retention and its importance in the pathogenesis of cardiac edema]." 06/01/1952 - "The measurement of total "sodium space" and total body sodium in normal individuals and in patients with cardiac edema." 03/01/1949 - "The retention of the sodium in cardiac edema; a review." 10/04/1969 - "The appreciation of a few simplified facts about cardiac edema and renal reabsorption of sodium makes the clinical pharmacology of the diuretics much easier to understand, remember and apply."
9.	Spironolactone (Aldactone)FDA LinkGeneric 12/08/1961 - "Spironolactone in the treatment of hepatic and cardiac edemas]." 12/10/1960 - "[First results obtained with the use of the spirolactone SC-9420 (aldactone) in the treatment of cardiac edema]." 04/01/1966 - "[On the mechanism of action of antialdosterone compounds (aldactone and progesterone) in the treatment of cardiac edema]." 04/01/1965 - "[Treatment of cardiac edemas by a combination of micronized aldactone and Altizide]." 07/01/1965 - "FURTHER EXPERIENCE WITH SPIRONOLACTONE-HYDRO-CHLOROTHIAZIDE (ALDACTAZIDE-A) IN THE LONG-TERM TREATMENT OF REFRACTORY CARDIAC EDEMA."
10.	Hydrochlorothiazide (Esidrix)FDA LinkGeneric 10/01/1960 - "[Hydrochlorothiazide in the treatment of cardiac edema and of its effects on electrolyte metabolism]." 12/05/1959 - "[Treatment of cardiac edema by hydrochlorothiazide]." 02/01/1974 - "[Treatment of cardiac edema with a new diuretic (combination of amiloride hydrochlorate and hydrochlorothiazide)]." 01/01/1973 - "[The treatment of cardiac edemas with a new diuretic (combination of amiloride and hydrochlorothiazide)]." 01/01/1973 - "[Comparison of the combination of hydrochlorothiazide and amiloride (Moduretic) and furosemide in the treatment of cardiac edema]."

Therapies and Procedures

1.	Sodium-Restricted Diet (Diet, Sodium Restricted) 01/01/1963 - "[On the utility of the strict salt-free diet for the dehydration of cardiac edema]." 03/01/1962 - "[On the use of the strict salt-free diet for dehydration in cardiac edema]." 08/01/1953 - "[Diuretic action of potassium associated with low sodium diet in treatment of cardiac edema; first results]."
2.	Transplants (Transplant) 09/01/1998 - "Graft reperfusion injury was evaluated at 6 to 24 hours by neutrophil infiltration (myeloperoxidase [MPO]), cardiac edema (%wt/wt), and histologic injury (percent contraction band necrosis). " 10/01/1997 - "Lipopolysaccharide-pretreated PVG heart grafts showed increased ICAM-1 expression by Northern blot and immunohistochemical analysis leading to increased reperfusion injury as assessed by neutrophil infiltration (myeloperoxidase), cardiac edema (percentage wet weight), and histologic injury (percentage area of contraction band necrosis), which was reversed by recipient treatment with anti-ICAM-1 monoclonal antibody. "
3.	Induced Heart Arrest (Cardioplegia) 03/01/2006 - "Cardiac edema percentage (p < .004) and LVM (p < .05) were significantly decreased in the WB group compared with 4:1. WB cardioplegia increases the number of hearts successfully weaned from CPB and decreases cardiac edema in our porcine model of acute myocardial ischemia. " 10/29/2010 - "When hearts were perfused with epoxomicin during cardioplegia, the cardiac proteasome was inhibited immediately, all of these hearts started beating after 24hCI in UW plus epoxomicin and cardiac edema and myocardial ultrastructure were comparable to hearts after 12hCI. "
4.	Sternotomy 11/01/1995 - "Severe hemodynamic dysfunction may follow closure of the median sternotomy in patients with myocardial edema, cardiac dilatation, postcardiotomy shock, or raised end-expiratory alveolar pressure. "
5.	Sympathectomy (Sympathectomies) 01/15/2016 - "Takotsubo syndrome/QTc interval prolongation/myocardial edema/cardiac sympathetic denervation/cardiac arrhythmias: A quintet needing exploration."