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Echothiophate Iodide (Phospholine Iodide)

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A potent, long-acting cholinesterase inhibitor used as a miotic in the treatment of glaucoma.

Also Known As:

Phospholine Iodide; Ecothiopate Iodide; 2-((Diethoxyphosphinyl)thio)-N,N,N,-trimethylethanaminium iodide; Ecothiophate Iodide; Iodide, Echothiophate; Iodide, Ecothiopate; Iodide, Ecothiophate; Iodide, Phospholine; Ethanaminium, 2-((diethoxyphosphinyl)thio)-N,N,N-trimethyl-, iodide

Networked: 80 relevant articles (0 outcomes, 1 trials/studies)

Drug Context: Research Results

Organic Chemicals: 58
- Organophosphorus Compounds: 163
  - Organothiophosphorus Compounds
    - Echothiophate Iodide: 80
      - GT-165: 1
      - GT 161
- Sulfur Compounds: 135
  - Organothiophosphorus Compounds
    - Echothiophate Iodide: 80
      - GT-165: 1
      - GT 161

Experts

1.	Wilson, M Edward: 1 article (04/2015)
2.	Trivedi, Rupal H: 1 article (04/2015)
3.	Kraus, Courtney L: 1 article (04/2015)
4.	Geyer, Orna: 1 article (08/2010)
5.	Levinger, Elia: 1 article (08/2010)
6.	Buckman, Gila: 1 article (08/2010)
7.	Segev, Eitan: 1 article (08/2010)
8.	Schmidt, K G: 1 article (08/2010)
9.	Horowitz, Yosefa: 1 article (08/2010)

Related Diseases

1.	Glaucoma 01/01/1969 - "V. Studies on the lens in glaucoma eyes after discontinuance of echothiophate (phospholine iodide) therapy." 04/01/2015 - "To report the intraocular pressure (IOP)-lowering ability and side-effect profile of echothiophate iodide (EI) in the control of glaucoma in aphakic and pseudophakic eyes of children. " 08/01/2010 - "Lowering of IOP by echothiophate iodide in pseudophakic eyes with glaucoma." 03/01/1971 - "[Phospholine iodide in the management of glaucoma]." 02/08/1969 - "[Experiences with phospholine iodide in the therapy of glaucoma]."
2.	Esotropia (Esophoria) 12/01/1997 - "Echothiophate iodide, given postoperatively for congenital esotropia, does not improve the surgical results during the first postoperative year." 12/01/1997 - "To examine the postoperative effect of echothiophate iodide in children who underwent surgery to congenital esotropia, and to find out whether it significantly reduced the residual esotropia. " 07/01/1982 - "Echothiophate iodide: its use in accommodative esotropia (high Ac/A ratio)." 10/01/1981 - "The author discusses the results of phospholine iodide therapy on 112 children with convergent strabismus and comes to the conclusion that the possible complications of this therapy are not outweighed by its only very modest success." 01/01/1967 - "[Treatment of esotropias with phospholine iodide]."
3.	Open-Angle Glaucoma (Glaucoma, Open Angle) 06/01/1963 - "Low-concentration phospholine iodide therapy in open-angle glaucoma." 07/01/1977 - "The potential association of ocular pemphigoid with Phospholine Iodide medications in the treatment of open-angle glaucoma is under investigation." 09/01/1972 - "Comparison of pilocarpine and echothiophate iodide in open-angle glaucoma." 03/01/1968 - "[Phospholine iodide compared with pilocarpine in the management of simple glaucoma]." 07/01/1965 - "Comparison between the tonographic effects of pilocarpine and echothiophate iodide in glaucoma simplex."
4.	Cataract (Cataracts) 01/01/1983 - "Echothiophate iodide cataracts in monkeys. " 10/01/1966 - "Lens opacities in glaucoma patients on phospholine iodide therapy." 01/01/1966 - "Lens opacities in glaucoma patients on phospholine iodide therapy." 01/01/1968 - "I. The frequency of anterior subcapsular vacuoles in glaucoma eyes treated with echothiophate (Phospholine Iodide), pilocarpine or pilocarpine-eserine, and in nonglaucomatous untreated eyes with common senile cataract."
5.	Miosis 03/01/1988 - "The possible functional involvement of iris SP was studied in 22 episodic cluster headache (CH) patients by using the anticholinesterase agent echothiophate iodide (EI), which also induces an atropine-resistant miosis, putatively due to release of SP from trigeminal sensory neurons. " 08/15/1985 - "The anticholinesterase agent echothiophate iodide (EI) and the cholinergic agent pilocarpine hydrochloride (pilocarpine), drugs commonly used in glaucoma therapy, cause miosis in rabbits as well as in man. " 08/15/1985 - "Effects of the substance P antagonist [D-Arg1,D-Pro2,D-Trp7,9,Leu11]SP on miosis caused by echothiophate iodide or pilocarpine hydrochloride." 10/01/1986 - "In addition, nimodipine abolished the miosis caused by echothiophate iodide eye drops, a putative releaser of substance P from trigeminal sensory nerve endings. "

Related Drugs and Biologics

1.	Pilocarpine (Ocusert)
2.	Echothiophate Iodide (Phospholine Iodide)
3.	Ophthalmic Solutions (Eye Drops)
4.	Cholinesterases (Cholinesterase)
5.	Timolol (Blocadren)
6.	Substance P
7.	Carbachol (Carbastat)
8.	demecarium bromide (demecarium)
9.	pralidoxime (Protopam Chloride)
10.	dipivefrin (Propine)

Related Therapies and Procedures

1.	Cataract Extraction
2.	Electric Stimulation Therapy (Electrotherapy)
3.	Aftercare (After-Treatment)