Hepatic Echinococcosis

Liver disease caused by infections with parasitic tapeworms of the genus ECHINOCOCCUS, such as Echinococcus granulosus or Echinococcus multilocularis. Ingested Echinococcus ova burrow into the intestinal mucosa. The larval migration to the liver via the PORTAL VEIN leads to watery vesicles (HYDATID CYST).

Also Known As:

Networked: 299 relevant articles (25 outcomes, 31 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Infections
2.	Budd-Chiari Syndrome (Budd Chiari Syndrome)
3.	Obstructive Jaundice (Cholestatic Jaundice)
4.	Hepatic Echinococcosis
5.	Cysts

Experts

1.	Wen, Hao: 15 articles (08/2021 - 09/2011)
2.	Wang, Wentao: 11 articles (10/2022 - 11/2017)
3.	Shen, Shu: 10 articles (10/2022 - 11/2017)
4.	Qiu, Yiwen: 9 articles (10/2022 - 11/2017)
5.	Yang, Xianwei: 9 articles (10/2022 - 11/2017)
6.	Zhao, Jin-Ming: 6 articles (08/2021 - 09/2011)
7.	Huang, Bin: 5 articles (10/2022 - 01/2018)
8.	Fan, Haining: 5 articles (01/2022 - 09/2019)
9.	Yang, Chong: 5 articles (12/2021 - 01/2020)
10.	Zhang, Yu: 5 articles (12/2021 - 01/2020)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Hepatic Echinococcosis:

1.	Albendazole (Albenza)FDA Link 02/28/2011 - "Long-term use of albendazole is the main treatment for nonresectable advanced hepatic alveolar echinococcosis." 03/01/2018 - "We conducted a case-series study with the aim of evaluating the correlation between seropositivity, socio-epidemiological data, pre-operative treatment with albendazole and viability of protoscolices in human hepatic hydatid cysts. " 01/01/2023 - "At this point, the patient was diagnosed with hepatic echinococcosis based on a serological examination and oral albendazole treatment was initiated. " 10/01/2022 - "Decrease in the viability of protoscoleces in hepatic hydatid cysts after 2 weeks administration of oral albendazole at a dose of 10 mg/kg/day preoperatively, is not significant. " 08/01/2021 - "Long-term albendazole treatment should be given to all patients with unresectable hepatic alveolar echinococcosis as dramatic regression is possible in 15%-20%. "
2.	AnthelminticsIBA 08/01/2006 - "So, conservative surgical management of uncomplicated hepatic hydatid cysts with perioperative anthelmintic chemotherapy supposed to be a simple, safe and effective approach. " 03/01/2006 - "This study aims to emphasize the perioperative administration of anthelmintic therapy over the different surgical procedures aimed at curing HD, because radical resection remains the only potentially curative treatment for hepatic echinococcosis. "
3.	Antiparasitic Agents (Antiparasitics)IBA 01/01/2023 - "Clinical and laboratory findings improved after drainage, with hospital discharge under oral antiparasitic treatment before complete surgical resection of the hepatic hydatid cyst. " 03/01/1991 - "Since no effective parasiticide agent is available, hepatic hydatidosis must be treated surgically. " 02/01/2014 - "Conduction of active screening examination of population in the regions, endemic for echinococcosis, application of effective intraoperative methods for prophylaxis of abdominal dissemination of invasive material, usage of antiparasitic chemical and thermal processing of cystic contents and its walls, left after echinococcectomy performance, postoperative prophylactic application of antiparasitic medicinal therapy have had permitted to lower the hepatic echinococcosis recurrence rate (down to 1.3% in last 5 yrs)." 04/01/2014 - "Conduction of active screening examination of patients in regions, which are endemic for echinococcosis, application of effective mimiinvasive surgical accesses, intraoperative methods for prophylaxis of abdominal dissemination of the invasive material, antiparasitic chemical and thermal processing of the cyst content and the residual cavity walls after echinococcectomy, postoperative prophylactic administration of antiparasitic medicinal therapy have permitted to reduce significantly (up to 1.3% in last 5 yrs) the rate of the hepatic echinococcosis recurrence."
4.	Therapeutic UsesIBA 01/01/2023 - "Oral Delivery of Anti-Parasitic Agent-Loaded PLGA Nanoparticles: Enhanced Liver Targeting and Improved Therapeutic Effect on Hepatic Alveolar Echinococcosis." 01/01/2022 - "Further, nano drug delivery systems boosting the therapeutic effect on hepatic alveolar echinococcosis are also reviewed. " 12/01/2011 - "[Therapeutic effect of hepatic artery infusion with albendazole microspheres on hepatic alveolar echinococcosis in rats]." 12/01/2011 - "Hepatic artery infusion with albendazole solid dispersion-chitosan microspheres shows certain therapeutic effect on hepatic alveolar echinococcosis in rats." 12/01/2011 - "To observe therapeutic effect of hepatic artery infusion of albendazole solid dispersion-chitosan microspheres on hepatic alveolar echinococcosis (HAE) in rats. "
5.	Biomarkers (Surrogate Marker)IBA 03/10/2022 - "Importantly, our findings suggested that identified exosomal circRNAs could be a potential biomarker for the detection of hepatic alveolar echinococcosis serum and may help to understand the pathogenesis of hepatic alveolar echinococcosis." 01/01/2018 - "Plasma IL-23 and IL-5 as surrogate markers of lesion metabolic activity in patients with hepatic alveolar echinococcosis."
6.	Ferritins (Ferritin)IBA 01/01/2022 - "The serum ferritin (SF) levels of patients with hepatic alveolar echinococcosis (HAE) were compared to the laboratory reference value, and the correlation between SF and associated parameters in patients with HAE was assessed. " 01/01/2022 - "CLINICAL SIGNIFICANCE AND CORRELATION ANALYSIS OF SERUM FERRITIN IN PATIENTS WITH HEPATIC ALVEOLAR ECHINOCOCCOSIS." 11/22/2019 - "The liver-to-muscle signal intensity ratio was (1.95 ± 0.57) in patients with hepatic alveolar echinococcosis and (2.22 ± 0.28) in healthy volunteers (t = 2.022, P < 0.05), and the liver-to-muscle signal intensity ratio was negatively associated the serum ferritin level in patients with hepatic alveolar echinococcosis (rs = -0.446, P < 0.01). " 11/22/2019 - "Abnormal iron deposition is detected in the liver of patients with hepatic alveolar echinococcosis, and serum ferritin level may be helpful for the identification of abnormal iron deposition in the liver of patients with hepatic alveolar echinococcosis. " 11/22/2019 - "To assess the value of MRI combined with serum ferritin analysis in measurement of hepatic iron deposition among patients with hepatic alveolar echinococcosis. "
7.	Tryptophan (L-Tryptophan)FDA Link 10/01/2019 - "Compared efficacy of University of Wisconsin and histidine-tryptophan-ketoglutarate solutions in ex-situ liver resection and autotransplantation for end-stage hepatic alveolar echinococcosis patients."
8.	SuspensionsIBA 02/01/2014 - "To observe the morphological change in the pathological process of Echinococcus multilocularis in liver of infected rats after treatment with liposome entrapped albendazole and iodized oil suspension through portal vein, and investigate its efficacy against hepatic alveolar echinococcosis. "
9.	Liposomes (Liposome)IBA 02/01/2014 - "To observe the morphological change in the pathological process of Echinococcus multilocularis in liver of infected rats after treatment with liposome entrapped albendazole and iodized oil suspension through portal vein, and investigate its efficacy against hepatic alveolar echinococcosis. "
10.	IronIBA 11/22/2019 - "The liver-to-muscle signal intensity ratio measured by MRI may be a non-invasive approached used to assess the hepatic iron deposition in patients with hepatic alveolar echinococcosis. " 11/22/2019 - "[Value of magnetic resonance imaging in assessment of iron deposition among patients with hepatic alveolar echinococcosis: a preliminary evaluation]." 11/22/2019 - "Abnormal iron deposition is detected in the liver of patients with hepatic alveolar echinococcosis, and serum ferritin level may be helpful for the identification of abnormal iron deposition in the liver of patients with hepatic alveolar echinococcosis. " 11/22/2019 - "To assess the value of MRI combined with serum ferritin analysis in measurement of hepatic iron deposition among patients with hepatic alveolar echinococcosis. "

Therapies and Procedures

1.	Autologous Transplantation 01/01/2019 - "Through cautious evaluation of operability, liver function, and residual liver volume, together with delicate operative techniques and careful postoperative management, ex vivo liver resection combined with autotransplantation can achieve good results in the treatment of end-stage hepatic alveolar echinococcosis." 06/02/2023 - "Portal vein embolization combined with ex vivo liver resection and autotransplantation: A novel treatment strategy for end-stage and metastatic hepatic alveolar echinococcosis." 10/01/2019 - "The present study aimed to compare their efficacy in end-stage hepatic alveolar echinococcosis patients who underwent ex-situ liver resection and autotransplantation (ELRA). " 02/01/2019 - "The aim of this study was to compare the clinical outcomes of ex vivo liver resection and autotransplantation (ERAT) with allotransplantation in patients with end-stage hepatic alveolar echinococcosis (HAE). " 01/01/2018 - "Novel techniques and preliminary results of ex vivo liver resection and autotransplantation for end-stage hepatic alveolar echinococcosis: A study of 31 cases."
2.	Drug Therapy (Chemotherapy) 01/01/2006 - "Drug therapy has scolicidal activity bat are clinically effective in less than 30 % of patients with hepatic hydatidosis. " 10/01/2018 - "Nondestructive three-dimensional (3D) micromorphological imaging technique is essential for hepatic alveolar echinococcosis (HAE) disease to determine its damage level and early diagnosis, assess relative drug therapy and optimize treatment strategies. " 01/01/2014 - "The man had previous excision of chest and hepatic hydatid cysts (resp., 10 and 3 years ago) and after primary mediastinal and spinal involvement (3 years ago) he was lost to follow-up and discontinued drug therapy. " 03/01/2005 - "For patients who fail drug therapy alone, PAIR is a safe and effective procedure of choice for patients with hepatic echinococcosis, and perhaps other anatomic sites of infection such as lung, peritoneum, kidney, and other viscera. " 10/15/2019 - "For the advanced hepatic echinococcosis patients with refractory radical resection, the palliative surgery combined with chemotherapy, liver transplantation, drug therapy, and radiofrequency microwave ablation may provide comprehensive tools. "
3.	Hepatectomy 01/01/2022 - "Corrigendum: Comparison of the Efficacy of Anatomic and Non-anatomic Hepatectomy for Hepatic Alveolar Echinococcosis: Clinical Experience of 240 Cases in a Single Center." 01/01/2022 - "Corrigendum: Comparison of the Efficacy of Anatomic and Non-anatomic Hepatectomy for Hepatic Alveolar Echinococcosis: Clinical Experience of 240 Cases in a Single Center." 01/01/2021 - "Comparison of the Efficacy of Anatomic and Non-anatomic Hepatectomy for Hepatic Alveolar Echinococcosis: Clinical Experience of 240 Cases in a Single Center." 01/01/2021 - "Methods: A total of 200 patients with complicated hepatic echinococcosis, admitted to our hospital between May 2019 and December 2020, who underwent radical hepatectomy, were enrolled in the present study. " 06/14/2022 - "A precise evaluation of liver reserve function in patients with hepatic alveolar echinococcosis (HAE) prior to hepatectomy could substantially increase the success rate of the operation and reduce the incidence of postoperative complications. "
4.	Therapeutics 02/01/2018 - "The aim of this study was to evaluate different surgical therapies for hepatic alveolar echinococcosis in different clinical stages.We" 05/01/2006 - "In this study, we present the causes and management of recurrences after surgical therapy of the hepatic hydatid cysts. " 10/01/2019 - "We recommend bridging therapy by selective angiography and embolization for hemorrhagic hepatic hydatid cyst before definitive surgical treatment." 01/01/2019 - "We emphasize on the new World Health Organization classification of hepatic echinococcosis with examples from our clinical practice at AUBMC, and finally we describe the treatment, including medical and interventional therapies." 07/01/2018 - "The hepatic hydatid cyst therapy is multimodal, including medical, surgical, and, lately, minimally invasive techniques. "
5.	Cystectomy 11/01/2014 - "Cystojejunostomy is an effective and safe surgical approach for the treatment of giant hepatic hydatid cysts, with a lower rate of morbidity than partial cystectomy, and thus may be the surgical treatment of choice for giant hepatic hydatid cysts." 03/17/2021 - "Background Laparoscopic closed cystectomy of the hepatic hydatid cyst (HHC) is increasingly being performed as it has improved postoperative recovery and reduced morbidity. " 03/17/2021 - "Feasibility of Laparoscopic Closed Cystectomy for Hepatic Hydatid Cyst in Segments VI, VII, and VIII." 10/01/2017 - "Comparison of mid-term clinical outcomes of laparoscopic partial cystectomy versus conventional partial cystectomy for the treatment of hepatic hydatid cyst." 01/01/2015 - "Hepatic hydatid cyst, Mortality, Partial cystectomy."