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Hepatic Echinococcosis

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Liver disease caused by infections with parasitic tapeworms of the genus ECHINOCOCCUS, such as Echinococcus granulosus or Echinococcus multilocularis. Ingested Echinococcus ova burrow into the intestinal mucosa. The larval migration to the liver via the PORTAL VEIN leads to watery vesicles (HYDATID CYST).

Also Known As:

Echinococcosis, Hepatic; Alveolar Echinococcoses, Hepatic; Alveolar Echinococcosis, Hepatic; Cyst, Hepatic Hydatid; Cysts, Hepatic Hydatid; Echinococcis, Hepatic Alveolar; Echinococcoses, Hepatic; Echinococcoses, Hepatic Alveolar; Hepatic Alveolar Echinococcis; Hepatic Alveolar Echinococcoses; Hepatic Alveolar Echinococcosis; Hepatic Echinococcoses; Hepatic Hydatid Cyst; Hepatic Hydatid Cysts; Hepatic Hydatidoses; Hepatic Hydatidosis; Hydatid Cysts, Hepatic; Hydatidoses, Hepatic; Alveolar Echinococcis, Hepatic; Echinococcosis, Hepatic Alveolar; Hydatid Cyst, Hepatic; Hydatidosis, Hepatic

Networked: 121 relevant articles (9 outcomes, 12 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Infection
2.	Hepatic Echinococcosis
3.	Cysts
4.	Echinococcosis (Hydatid Cysts)
5.	Rupture

Experts

1.	Wen, Hao: 4 articles (01/2015 - 09/2011)
2.	Aydinli, Bulent: 3 articles (09/2015 - 12/2006)
3.	Ren, Wei-Xin: 3 articles (07/2015 - 12/2011)
4.	Zhang, Hai-Xiao: 3 articles (07/2015 - 12/2011)
5.	Erzurumlu, Kenan: 3 articles (08/2014 - 03/2005)
6.	Sun, Hong: 3 articles (12/2011 - 02/2004)
7.	Zhang, Shi-jie: 3 articles (08/2011 - 02/2004)
8.	Kantarci, Mecit: 2 articles (09/2015 - 12/2006)
9.	Gu, Jun-Peng: 2 articles (07/2015 - 12/2011)
10.	Zhu, Di-Wen: 2 articles (07/2015 - 02/2014)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Hepatic Echinococcosis:

1.	Albendazole (Albenza)FDA Link 02/28/2011 - "Long-term use of albendazole is the main treatment for nonresectable advanced hepatic alveolar echinococcosis." 05/01/1993 - "Percutaneous drainage versus albendazole therapy in hepatic hydatidosis: a prospective, randomized study." 08/01/2014 - "Long-term outcomes of intraoperative and perioperative albendazole treatment in hepatic hydatidosis: single center experience." 04/01/2013 - "After undergoing several exams, we diagnosed hepatic hydatidosis and the patient was treated with albendazole; however, after five months of uninterrupted treatment the patient again consulted and his liver test showed marked hepatocellular damage. " 01/01/2013 - "We herein report two asymptomatic cases of hepatic echinococcosis that were successfully treated with percutaneous aspiration-injection-reaspiration (PAIR) plus albendazole."
2.	Liposomes (Liposome)IBA 02/01/2014 - "To observe the morphological change in the pathological process of Echinococcus multilocularis in liver of infected rats after treatment with liposome entrapped albendazole and iodized oil suspension through portal vein, and investigate its efficacy against hepatic alveolar echinococcosis. "
3.	Iodized OilIBA 02/01/2014 - "To observe the morphological change in the pathological process of Echinococcus multilocularis in liver of infected rats after treatment with liposome entrapped albendazole and iodized oil suspension through portal vein, and investigate its efficacy against hepatic alveolar echinococcosis. "
4.	albendazole sulfoxideIBA 06/01/2005 - "To determine the plasmatic and intracystal concentrations of albendazole sulfoxide (AS) and correlate them with the viability of the scolices in patients surgically treated for hepatic hydatid cysts (HHC) that received albendazole preoperatively, as an indirect way of evaluating the scolicide efficacy of the drug. "
5.	benzimidazoleIBA 12/01/2006 - "The purposes of this study were to describe and adapt the relevant methods of computed tomography (CT) and stereology to estimate parasitic volume in the liver, to compare the efficiency of benzimidazole treatment in hepatic alveolar echinococcosis (AE), and to determine whether the response rates measured by the stereological method are correlated with those measured by simple volumetric measurements (SVM). " 01/01/2011 - "PAIR seems promising, but there is insufficient evidence to support or refute PAIR with or without benzimidazole coverage for treating patients with uncomplicated hepatic hydatid cyst. " 01/01/2011 - "Percutaneous needle aspiration, injection, and re-aspiration with or without benzimidazole coverage for uncomplicated hepatic hydatid cysts." 01/01/2006 - "PAIR seems promising, but there is insufficient evidence to support or refute PAIR with or without benzimidazole coverage for treating patients with uncomplicated hepatic hydatid cyst. " 01/01/2006 - "Percutaneous needle aspiration, injection, and reaspiration with or without benzimidazole coverage for uncomplicated hepatic hydatid cysts."
6.	salicylhydroxamic acid (SHAM)IBA 01/01/2011 - "To assess the benefits and harms of PAIR with or without benzimidazole coverage for patients with uncomplicated hepatic hydatid cyst in comparison with sham/no intervention, surgery, or medical treatment. " 01/01/2006 - "To assess the benefits and harms of PAIR with or without benzimidazole coverage for patients with uncomplicated hepatic hydatid cyst in comparison with sham/no intervention, surgery, or medical treatment. " 01/01/2011 - "Only randomised clinical trials using the PAIR method with or without benzimidazole coverage as the experimental treatment of uncomplicated hepatic hydatid cyst (ie, hepatic hydatid cysts, which are not infected and do not have any communication with the biliary tree or other viscera) versus no intervention, sham puncture (ie, performing all steps for puncture, pretending PAIR being performed, but actually not performing the procedure), surgery, or chemotherapy were included. " 01/01/2006 - "Only randomised clinical trials using the PAIR method with or without benzimidazole coverage as the experimental treatment of uncomplicated hepatic hydatid cyst (ie, hepatic hydatid cysts which are not infected and do not have any communication with the biliary tree or other viscera) versus no intervention, sham puncture (ie, performing all steps for puncture, pretending that PAIR is being performed, but actually not performing the procedure proper), surgery, or chemotherapy were included. "
7.	Immunoglobulin E (IgE)IBA 07/01/1986 - "[Diagnostic value of the determination of total and specific IgE in hepatic hydatidosis]." 07/02/1983 - "[The value of total IgE serum concentrations in the diagnosis of hepatic hydatid cyst]." 12/01/1989 - "[An indirect hemagglutination study of total IgE and complement fractions C3c and C4 in patients with hepatic hydatidosis and undergoing therapy]." 01/01/2007 - "[Precision of ELISA-IgE and ELISA-IgG determination in the postoperative follow-up of patients with hepatic echinococcosis]."
8.	Immunoglobulin G (IgG)IBA 12/01/2006 - "So, there is a need for accurately designed randomized trials with precise goals to compare pericystectomy versus a specific modified endocystectomy technique for the treatment of hepatic hydatid cysts 8 cm or less in diameter in Egyptian patients, regarding the operative time, intra-operative blood loss, complications and long-term recurrence and to test the role of anti-hydatid IgG4 in diagnosis and detection of early recurrence. " 01/01/2007 - "[Precision of ELISA-IgE and ELISA-IgG determination in the postoperative follow-up of patients with hepatic echinococcosis]."
9.	Fluorodeoxyglucose F18 (Fludeoxyglucose F 18)FDA Link 01/01/2015 - "Objective of our study is qualitative and quantitative comparison of contrast enhanced ultrasound (CEUS) and 18F-FDG PET-CT in monitoring hepatic alveolar echinococcosis (HAE). "
10.	Complement System Proteins (Complement)IBA 12/01/1989 - "[An indirect hemagglutination study of total IgE and complement fractions C3c and C4 in patients with hepatic hydatidosis and undergoing therapy]."

Therapies and Procedures

1.	Drug Therapy (Chemotherapy) 01/01/2006 - "Drug therapy has scolicidal activity bat are clinically effective in less than 30 % of patients with hepatic hydatidosis. " 08/01/2006 - "So, conservative surgical management of uncomplicated hepatic hydatid cysts with perioperative anthelmintic chemotherapy supposed to be a simple, safe and effective approach. " 01/01/2014 - "The man had previous excision of chest and hepatic hydatid cysts (resp., 10 and 3 years ago) and after primary mediastinal and spinal involvement (3 years ago) he was lost to follow-up and discontinued drug therapy. " 03/01/2005 - "For patients who fail drug therapy alone, PAIR is a safe and effective procedure of choice for patients with hepatic echinococcosis, and perhaps other anatomic sites of infection such as lung, peritoneum, kidney, and other viscera. " 01/01/2011 - "Only randomised clinical trials using the PAIR method with or without benzimidazole coverage as the experimental treatment of uncomplicated hepatic hydatid cyst (ie, hepatic hydatid cysts, which are not infected and do not have any communication with the biliary tree or other viscera) versus no intervention, sham puncture (ie, performing all steps for puncture, pretending PAIR being performed, but actually not performing the procedure), surgery, or chemotherapy were included. "
2.	Cystectomy 11/01/2014 - "Cystojejunostomy is an effective and safe surgical approach for the treatment of giant hepatic hydatid cysts, with a lower rate of morbidity than partial cystectomy, and thus may be the surgical treatment of choice for giant hepatic hydatid cysts." 01/01/2015 - "Hepatic hydatid cyst, Mortality, Partial cystectomy." 11/01/2006 - "Omentoplasty is an easy and effective surgical method for the treatment of hepatic echinococcosis but is not different than partial cystectomy and external drainage in regard to morbidity, mortality, and recurrence." 04/01/2005 - "In a retrospective survey over the past 20 years (1982-2001) there were 36 patients (13 men and 23 women, with a mean age of 50 years) with hepatic echinococcosis, treated by partial cystectomy and omentoplasty. " 09/01/2000 - "Management of residual cavity after partial cystectomy for hepatic hydatidosis: comparison of omentoplasty with external drainage."
3.	Surgical Instruments (Clip) 07/01/2014 - "This study was undertaken to demonstrate the efficacy of the Hydatid Trocar Canula system for safe and effective treatment of hepatic hydatid cysts. " 07/01/2014 - "The correct use of the Hydatid Trocar Canula system allows for spillage-free and complete evacuation of hepatic hydatid cysts." 01/01/2012 - "[Use of a laparoscopic trocar for the removal of hepatic hydatid cysts]."
4.	Catheters 07/01/2011 - "Percutaneous suction and large bore catheter drainage of Gharbi type III hepatic hydatid cysts is a safe and effective alternative therapy." 07/01/2011 - "Under sonography guidance the complex heterogeneous hepatic hydatid cysts were treated percutaneously using large bore drainage catheter and active mechanical suction. " 07/01/2011 - "Mechanical suction through wide bore catheters for nonsurgical management of Gharbi type III hepatic hydatid cysts." 10/01/2008 - "After phrenotomy, the hepatic hydatid cyst was evacuated without capitonnage, and a Folly catheter was left in the cavity. " 07/01/2011 - "To present our experience with management of complex hepatic hydatid cysts (Gharbi type III), using percutaneous large bore catheter drainage followed by active mechanical suction of cyst contents. "
5.	Aftercare (After-Treatment) 01/01/2003 - "Follow-up problems and changes in obliteration of the residual cystic cavity after treatment for hepatic hydatidosis." 10/31/1985 - "Despite the fact that previous reports, and also one of the cases reported by us, point to a favourable evolution of the hepatic hydatidosis after treatment with Mebendazole, the possibility that the multivesicular cyst-with a more spreading growth and a surgical treatment which is occasionally more difficult, may be induced by that drug would perhaps discourage its use." 02/01/2014 - "To observe the morphological change in the pathological process of Echinococcus multilocularis in liver of infected rats after treatment with liposome entrapped albendazole and iodized oil suspension through portal vein, and investigate its efficacy against hepatic alveolar echinococcosis. "