Dysplastic Nevus Syndrome (Dysplastic Nevus)

Clinically atypical nevi (usually exceeding 5 mm in diameter and having variable pigmentation and ill defined borders) with an increased risk for development of non-familial cutaneous malignant melanoma. Biopsies show melanocytic dysplasia. Nevi are clinically and histologically identical to the precursor lesions for melanoma in the B-K mole syndrome. (Stedman, 25th ed)

Also Known As:

Networked: 212 relevant articles (5 outcomes, 25 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Actinic Keratosis
2.	Melanoma (Melanoma, Malignant)
3.	Neoplasms (Cancer)
4.	Nevi and Melanomas
5.	Sunburn

Experts

1.	Diwan, A Hafeez: 5 articles (03/2007 - 11/2003)
2.	Gambichler, Thilo: 4 articles (06/2009 - 11/2008)
3.	Prieto, Victor G: 4 articles (03/2007 - 11/2003)
4.	Mihm, Martin C: 3 articles (07/2015 - 10/2005)
5.	Martinka, Magdalena: 3 articles (05/2015 - 09/2006)
6.	Li, Gang: 3 articles (12/2014 - 09/2006)
7.	Rotterdam, Sebastian: 3 articles (06/2009 - 05/2009)
8.	Kreuter, Alexander: 3 articles (06/2009 - 05/2009)
9.	Altmeyer, Peter: 3 articles (06/2009 - 05/2009)
10.	Sironen, Reijo: 2 articles (12/2015 - 01/2013)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Dysplastic Nevus Syndrome:

1.	Tretinoin (Retinoic Acid)FDA LinkGeneric 05/01/1994 - "These results suggest that there is concomitant clinical and histologic improvement in a significant percentage of dysplastic nevi treated with topical tretinoin. " 04/01/1990 - "This study shows a definite biological effect of topical tretinoin on some dysplastic nevi." 10/01/1986 - "This experience led us to conduct the present pilot trial of topical tretinoin in dysplastic nevus syndrome. " 05/01/1994 - "Five male patients with dysplastic nevi applied tretinoin to half of the back for 6 months. " 05/01/1994 - "We report the results of a pilot study of topical retinoic acid in patients with dysplastic nevi. "
2.	RetinoidsIBA 08/01/1988 - "In human cancer prevention, retinoids have been most effective for skin diseases, including actinic keratosis, keratoacanthoma, epidermodysplasia verruciformis, dysplastic nevus syndrome, and basal cell carcinoma. "
3.	CyanoacrylatesIBA 08/01/1989 - "Cyanoacrylate skin surface stripping: an improved approach for distinguishing dysplastic nevi from malignant melanomas." 08/01/1989 - "A cohort of 215 dysplastic nevi and malignant melanomas was studied by cyanoacrylate skin surface stripping (CSSS) and conventional histology. "
4.	CurcuminIBA 05/01/2013 - "Curcumin gel is also beneficial in the repair of photo-damaged skin, including pigmentary changes, solar elastosis, thinning of the skin with telangiectasia (actinic poikiloderma), and premalignant lesions such as actinic keratoses, dysplastic nevi, and advanced solar lentigines, but the repair process takes many months."
5.	MD1IBA 01/01/2015 - "Patients with MD1 showed significantly higher numbers of nevi, dysplastic nevi, and melanomas despite a significantly greater proportion of the control subjects reporting sunburns. "
6.	DNA (Deoxyribonucleic Acid)IBA 10/01/1999 - "DNA ploidy and nuclear morphometry for the classification of dysplastic nevi." 01/01/1995 - "The DNA excision repair capacity of 23 primary fibroblast lines from patients with dysplastic nevus syndrome was investigated and DNA repair synthesis ("unscheduled DNA synthesis") was determined after UV exposure. " 04/01/1993 - "DNA determination in dysplastic nevi. " 12/01/1990 - "Spitz and dysplastic nevi were studied by flow cytometry to search for DNA abnormality. " 06/01/2010 - "BRAF and NRAS genotyping was performed on genomic DNA (isolated using laser capture microdissection) from dysplastic nevi ranging in severity from mild (12), to moderate (11), and to severe (11). "
7.	Monoclonal AntibodiesIBA 02/01/1986 - "These human monoclonal antibodies appear to be useful in distinguishing malignant melanomas from benign nevi, with the exception of dysplastic nevi, and from basal and squamous cancers of the skin in routinely prepared tissue sections. " 04/01/1996 - "Studies of antigen expression in dysplastic nevi have been limited to some extent by difficulties in obtaining frozen nevi with which to react monoclonal antibodies. " 04/01/1996 - "Tumor antigen expression in compound dysplastic nevi and superficial spreading melanoma defined by a panel of nevomelanoma monoclonal antibodies." 06/01/2009 - "Immunohistologic study of benign nevi (BN), dysplastic nevi (DN), and primary superficial spreading melanoma (SSM) was performed for carcinoembryonic antigen (CEA) and CEA cell adhesion molecule-1 (CEACAM1) using monoclonal antibodies. " 09/01/1984 - "Using an indirect immunoperoxidase technique, 20 nevocellular nevi, 5 dysplastic nevi, 14 primary cutaneous melanomas, and 24 metastatic melanomas were tested with a panel of monoclonal antibodies to monomorphic determinants of Class I (HLA-A,B,C) and Class II (la-like) major histocompatibility complex antigens. "
8.	AntigensIBA 02/01/1987 - "By immunoperoxidase staining, the antigen was demonstrated on a large number of melanomas and in addition on 1 of 36 nevocellular, 3 of 4 Spitz, and 5 of 14 dysplastic nevi. " 10/31/1987 - "The immunohistochemical localization of melanoma-associated antigen p94 kd200 was investigated in frozen sections of 3 congenital nevi, 4 benign intradermal nevi, 1 regressing nevus, 1 blue nevus, 1 dysplastic nevus, 1 lentigo maligna, 1 superficial spreading melanoma and 2 metastatic melanomas. " 04/01/1996 - "Studies of antigen expression in dysplastic nevi have been limited to some extent by difficulties in obtaining frozen nevi with which to react monoclonal antibodies. " 04/01/1996 - "Tumor antigen expression in compound dysplastic nevi and superficial spreading melanoma defined by a panel of nevomelanoma monoclonal antibodies." 09/15/1989 - "No significant differences in antigen expression were found between dysplastic nevus cells and RGP melanoma, except that some antigens (nerve growth factor receptor and GD2/GD3 gangliosides) appear to be expressed at lower levels in RGP lesions, nor did VGP primary and metastatic melanomas show significant differences in antigen expression. "
9.	Cyclin D1IBA 06/01/2007 - "The aim of this study is to investigate cyclin D1 expression and Ki67 proliferative index in a group of melanocytic lesions to address the biologic significance of sporadic dysplastic nevi in the progression of melanocytic lesions. " 02/01/2001 - "Cyclin D1 expression in dysplastic nevi: an immunohistochemical study." 06/01/2007 - "The significance of Ki-67 proliferative index and cyclin D1 expression of dysplastic nevi in the biologic spectrum of melanocytic lesions." 02/01/2001 - "Cyclin D1 may be involved in the pathogenesis of dysplastic nevi. " 02/01/2001 - "Cyclin D1 overexpression in 23 dysplastic nevi was detected by an immunohistochemical technique. "
10.	Proteins (Proteins, Gene)IBA 01/01/2005 - "Our current study evaluated the expression of two mismatch repair proteins, hMLH1 and hMSH2, in dysplastic nevi (DN) and cutaneous melanoma (CM). " 01/01/2005 - "Altered expression of the DNA mismatch repair proteins hMLH1 and hMSH2 in cutaneous dysplastic nevi and malignant melanoma." 04/01/2010 - "In 149 lesions, including benign nevi, dysplastic nevi, radial growth phase melanomas, vertical growth phase melanomas, and melanoma metastases, proteins were evaluated by immunohistochemistry, and, in representative cases of benign nevi, vertical growth phase melanomas and melanoma metastases were evaluated by Western blotting. " 02/01/2006 - "Here, we have investigated, for the first time, the expression of Notch-1, Notch-2, Jagged-1, Jagged-2 and Delta-like 1 proteins, by immunohistochemistry, in a series of benign and malignant human melanocytic lesions: five common melanocytic nevi, five 'dysplastic nevi' and 20 melanomas (five in situ, five T1-T2, five T3-T4 and five metastatic melanomas). " 01/01/1991 - "We applied a simple silver staining technique to visualize nucleolar organizer regions associated proteins (AgNORs) for the study of 47 melanocytic lesions (20 malignant melanomas, 5 dysplastic nevi, 4 Spitz nevi, 2 Reed and Gartman's fusiform nevi and 16 melanocytic nevi). "

Therapies and Procedures

1.	Chemoprevention 06/01/2011 - "Feasibility of serial biopsies of large dysplastic nevi as a melanoma chemoprevention model." 10/01/2002 - "In this article, the management of patients with dysplastic nevi and the role for dermoscopy, photographic surveillance, genetic mapping and counseling, chemoprevention, and nevi removal are discussed." 03/01/2002 - "Dysplastic nevi, a likely precursor of melanoma, are also potential targets for chemoprevention strategies. " 05/01/1994 - "As potential precursors of melanoma and markers of increased melanoma risk, dysplastic nevi are suitable targets of strategies for melanoma chemoprevention. " 01/01/2006 - "The histological changes seen in a subset of treated nevi suggest a possible role for the use of topical immune response modifiers for the treatment of dysplastic nevi with the intent of melanoma chemoprevention. "
2.	Phototherapy (Light Therapy) 07/01/2007 - "Neonatal blue-light phototherapy could increase the risk of dysplastic nevus development." 06/01/2007 - "Neonatal blue-light phototherapy could increase the risk of dysplastic nevus development." 05/01/2007 - "Neonatal blue-light phototherapy could increase the risk of dysplastic nevus development."
3.	Heterologous Transplantation (Xenotransplantation) 10/01/2012 - "Furthermore, the cell-residual 60 kDa endodomain was exclusively detected in 62/79 primary and 15/18 metastatic melanomas, 8/9 melanoma cell lines, HT199 metastatic melanoma xenografts and atypical nests in 8/63 dysplastic nevi. " 04/14/2005 - "A DNA damage response was also observed in dysplastic nevi and in human skin xenografts, in which hyperplasia was induced by overexpression of growth factors. "
4.	Semiconductor Lasers 08/01/2001 - "Histologic features seen in changing nevi after therapy with an 810 nm pulsed diode laser for hair removal in patients with dysplastic nevi."
5.	Skin Care 04/01/1985 - "Patients with dysplastic nevi should adopt sensible patterns of skin care."