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Drug-Induced Dyskinesia (Dyskinesia, Drug Induced)

Abnormal movements, including HYPERKINESIS; HYPOKINESIA; TREMOR; and DYSTONIA, associated with the use of certain medications or drugs. Muscles of the face, trunk, neck, and extremities are most commonly affected. Tardive dyskinesia refers to abnormal hyperkinetic movements of the muscles of the face, tongue, and neck associated with the use of neuroleptic agents (see ANTIPSYCHOTIC AGENTS). (Adams et al., Principles of Neurology, 6th ed, p1199)
Also Known As:
Dyskinesia, Drug Induced; Dyskinesia, Drug-Induced; Medication-Induced Dyskinesia; Drug-Induced Dyskinesias; Dyskinesia, Medication Induced; Dyskinesias, Drug-Induced; Dyskinesias, Medication-Induced; Medication Induced Dyskinesia; Medication-Induced Dyskinesias; Dyskinesia, Medication-Induced
Networked: 99 relevant articles (10 outcomes, 8 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Parkinson Disease (Parkinson's Disease)
2. Dyskinesias (Dyskinesia)
3. Parkinsonian Disorders (Parkinsonism)
4. Amnesia (Dissociative Amnesia)
5. Tremor (Tremors)

Experts

1. Subramanian, Thyagarajan: 5 articles (01/2012 - 12/2005)
2. Lieu, Christopher A: 4 articles (01/2012 - 08/2010)
3. Deogaonkar, Milind: 4 articles (01/2012 - 12/2005)
4. Poewe, Werner: 2 articles (01/2020 - 01/2015)
5. Vitek, Jerrold L: 2 articles (12/2019 - 06/2011)
6. Jankovic, Joseph: 2 articles (05/2016 - 05/2016)
7. Vijayakumar, Dhanya: 2 articles (05/2016 - 05/2016)
8. Schwarz, Johannes: 2 articles (01/2014 - 11/2012)
9. Strecker, Karl: 2 articles (01/2014 - 11/2012)
10. Wegner, Florian: 2 articles (01/2014 - 11/2012)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Drug-Induced Dyskinesia:
1. Levodopa (L Dopa)FDA LinkGeneric
2. Dopamine Agents (Dopaminergic Agents)IBA
3. Reserpine (Serpasil)FDA Link
4. Dopamine (Intropin)FDA LinkGeneric
5. Amantadine (Aman)FDA LinkGeneric
6. Antipsychotic Agents (Antipsychotics)IBA
7. 5-HT2C Serotonin ReceptorIBA
8. Psychotropic Drugs (Psychoactive Drugs)IBA
9. NitrilesIBA
10. glycine amideIBA

Therapies and Procedures

1. Therapeutics
12/26/2019 - "It soon became apparent, however, that medical therapy was associated with side effects in the form of drug-induced dyskinesia and motor fluctuations and surgical therapies reemerged. "
08/01/2013 - "Two of these patients responded to dopaminergic therapy, with drug-induced dyskinesia observed in one. "
11/01/1998 - "Multiple factors have led to the resurgence of interest in the surgical treatment of PD: 1) recognition that long-term medical therapy for PD is often unsatisfactory, with patients eventually suffering from drug-induced dyskinesias, motor fluctuations, and variable responses to medication; 2) greater understanding of the pathophysiology of PD, providing a better scientific rationale for some previously developed procedures and suggesting new targets; and 3) use of improved techniques, such as computed tomography- and magnetic resonance imaging-guided stereotaxy and single-unit microelectrode recording, making surgical intervention in the basal ganglia more precise. "
01/01/2014 - "Bilateral subthalamic nucleus deep brain stimulation (STN-DBS) has been shown to improve motor function, motor fluctuations, health-related quality of life, and to reduce medication usage and drug-induced dyskinesia in patients with severe PD refractory to medical therapy. "
01/01/2011 - "These results suggest that the stable strictly unilateral HP rhesus monkey model of PD may not be a suitable animal model to test experimental therapeutics targeted against dyskinesias, and that bilateral parkinsonian rhesus models that readily demonstrate drug-induced dyskinesias and clinically relevant motor fluctuations are more appropriate for preclinical experimental testing of therapies designed to treat patients with advanced PD."
2. Pallidotomy
3. Deep Brain Stimulation
4. Microelectrodes
5. Drug Therapy (Chemotherapy)