Dydrogesterone

A synthetic progestational hormone with no androgenic or estrogenic properties. Unlike many other progestational compounds, dydrogesterone produces no increase in temperature and does not inhibit OVULATION.

Also Known As:

Networked: 116 relevant articles (15 outcomes, 27 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Clavel-Chapelon, Françoise: 4 articles (09/2014 - 01/2008)
2.	Fournier, Agnès: 4 articles (09/2014 - 01/2008)
3.	Bergeron, C: 4 articles (06/2010 - 08/2000)
4.	Boutron-Ruault, Marie-Christine: 3 articles (09/2014 - 03/2008)
5.	Mesrine, Sylvie: 3 articles (09/2014 - 03/2008)
6.	Beranič, Nataša: 3 articles (02/2013 - 05/2012)
7.	Schindler, Adolf E: 3 articles (02/2011 - 12/2009)
8.	Mueck, Alfred O: 3 articles (12/2010 - 10/2007)
9.	Szekeres-Bartho, Julia: 3 articles (03/2010 - 04/2005)
10.	Ferenczy, A: 3 articles (02/2006 - 01/2001)

Related Diseases

1.	Endometriosis (Adenomyosis) 10/01/2007 - "In conclusion, dydrogesterone is an effective and safe post-laparoscopic treatment for endometriosis." 01/01/2003 - "[Efficacy of duphaston treatment in women with endometriosis after reconstructive surgery]." 12/01/2009 - "The place of dydrogesterone in the treatment of endometriosis and adenomyosis." 10/01/2007 - "An open, prospective, multicenter study was designed to assess the efficacy and safety of dydrogesterone in the post-laparoscopic treatment of endometriosis in Indian patients. " 10/01/2007 - "Effective post-laparoscopic treatment of endometriosis with dydrogesterone."
2.	Spontaneous Abortion (Miscarriage) 06/01/2015 - "Although all the predictive and confounding factors could not be controlled for, the results of this systematic review show a significant reduction of 29% in the odds for miscarriage when dydrogesterone is compared to standard care indicating a real treatment effect. " 12/01/2012 - "Although all the predictive and confounding factors could not be controlled for, the results of this systematic review show a significant reduction of 47% in the odds for miscarriage when dydrogesterone is compared to standard care indicating a real treatment effect." 12/01/2009 - "The aim of this study was to determine whether dydrogesterone helps to preserve pregnancy in women with threatened miscarriage. " 10/01/2005 - "Oral dydrogesterone treatment during the first trimester of pregnancy: the prevention of miscarriage study (PROMIS). " 06/01/2015 - "There was a 10.5% (29/275) miscarriage rate after dydrogesterone administration compared to 23.5% in control women (odds ratio for miscarriage 0.29 [confidence interval 0.13-0.65] and 13% absolute reduction in the miscarriage rate). "
3.	Endometrial Hyperplasia 10/01/1997 - "Good protection against endometrial hyperplasia and cancer is provided by the dydrogesterone component. " 08/01/2000 - "Low incidence of endometrial hyperplasia with acceptable bleeding patterns in women taking sequential hormone replacement therapy with dydrogesterone." 12/01/2009 - "When used in hormone replacement therapy, 10mg dydrogesterone given sequentially provides adequate protection against endometrial hyperplasia in postmenopausal women using 2mg estradiol. " 03/01/2015 - "To compare the efficacy and safety of the levonorgestrel-releasing intrauterine device (LNG-IUD) with dydrogesterone applied for the same duration in patients having endometrial hyperplasia (EH) without atypia. " 03/01/2015 - "Levonorgestrel-releasing intrauterine device versus dydrogesterone for management of endometrial hyperplasia without atypia."
4.	Hemorrhage 02/20/2006 - "The aim of the study was to confirm the endometrial safety and describe the bleeding profile of continuous combined 1 mg 17beta-oestradiol and 5 mg dydrogesterone in post-menopausal women. " 12/01/2009 - "Dydrogesterone was continued until 1 week after the bleeding had stopped. " 12/01/2009 - "146 women who presented with mild or moderate vaginal bleeding during the first trimester of pregnancy were randomised to receive oral dydrogesterone (10mg b.i.d.) (n=86) or no treatment (n=60). " 12/01/2009 - "Dydrogesterone is particularly suitable in cases where the woman desires to become pregnant and to prevent bleeding problems. " 04/01/2008 - "Fasting blood samples were drawn in all women 3-6 days after spontaneous or dydrogesterone-induced withdrawal bleeding. "
5.	Habitual Abortion (Recurrent Miscarriage) 11/01/2014 - "The present study supports the use of dydrogesterone in women with recurrent abortions to improve pregnancy outcome, such as a reduction in abortions and improved gestational age and baby weight at delivery. " 11/01/2015 - "This study was designed to ascertain whether dihydrodydrogesterone (DHD), the major metabolite of dydrogesterone, is similarly capable of modulating cytokine production by peripheral blood mononuclear cells (PBMC) from women with a history of unexplained recurrent miscarriage. " 12/01/2005 - "In order to draw final conclusions as to the usefulness of dydrogesterone in women with a history of recurrent miscarriage, further controlled, blinded, randomised clinical trials are needed." 10/01/2005 - "A prospectively randomized, placebo-controlled study of 20 mg dydrogesterone per day during the first trimester of pregnancy in women aged between 18 and 38 and with a history of idiopathic recurrent miscarriage. " 10/01/2005 - "A planned study to test the hypothesis that dydrogesterone given during the first trimester of pregnancy can positively influence the immune system of women suffering from recurrent miscarriages and thereby lead to successful pregnancies. "

Related Drugs and Biologics

1.	Estradiol (Estrace)
2.	Progesterone
3.	Progestins (Progestagens)
4.	Hormones
5.	Norgestrel (DL-Norgestrel)
6.	Estrogens (Estrogen)
7.	Cyproterone Acetate
8.	Lipid A
9.	Dydrogesterone
10.	Medroxyprogesterone Acetate (Depo-Provera)

Related Therapies and Procedures

1.	Hormone Replacement Therapy (Therapy, Hormone Replacement)
2.	Estrogen Replacement Therapy
3.	Contraception (Birth Control)
4.	Aftercare (After-Treatment)
5.	Bed Rest (Bedrest)