Pituitary Dwarfism

A form of dwarfism caused by complete or partial GROWTH HORMONE deficiency, resulting from either the lack of GROWTH HORMONE-RELEASING FACTOR from the HYPOTHALAMUS or from the mutations in the growth hormone gene (GH1) in the PITUITARY GLAND. It is also known as Type I pituitary dwarfism. Human hypophysial dwarf is caused by a deficiency of HUMAN GROWTH HORMONE during development.

Also Known As:

Networked: 187 relevant articles (1 outcomes, 13 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Dwarfism
2.	Infection
3.	Acromegaly
4.	Empty Sella Syndrome
5.	Adenoma (Adenomas)

Experts

1.	Kooistra, H S: 5 articles (01/2015 - 01/2000)
2.	Mol, J A: 3 articles (12/2006 - 01/2000)
3.	Voorbij, A M W Y: 2 articles (01/2015 - 11/2014)
4.	Meij, B P: 2 articles (01/2015 - 12/2006)
5.	Miller, Richard A: 2 articles (08/2012 - 11/2006)
6.	Miki, Fumie: 2 articles (02/2004 - 02/2002)
7.	Sakai, Takashi: 2 articles (02/2004 - 02/2002)
8.	Wariishi, Masanobu: 2 articles (02/2004 - 02/2002)
9.	Grinwis, G C M: 1 article (01/2015)
10.	van Bruggen, L W L: 1 article (01/2015)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Pituitary Dwarfism:

1.	HormonesIBA 01/01/2015 - "Canine pituitary dwarfism or combined pituitary hormone deficiency (CPHD) in shepherd dogs is associated with an LHX3 mutation and can lead to a wide range of clinical manifestations. " 11/01/2014 - "Pituitary dwarfism in German Shepherd Dogs is associated with autosomal recessive inheritance and a mutation in LHX3, resulting in combined pituitary hormone deficiency. " 01/01/1995 - "In pituitary dwarfism, MRI reveals severe sella/pituitary gland and stalk hypoplasia with or without posterior pituitary ectopia, and empty sella, and this more frequently in patients with multiple pituitary hormone deficiency. " 06/01/1983 - "[Pituitary dwarfism that showed Perthes-like symptoms during thyroid hormone administration]." 01/01/1971 - "[Value of radioimmunological determination of the somatotropic hormone in a series of children with low body height for the diagnosis of pituitary dwarfism]."
2.	GonadotropinsIBA 04/01/1992 - "The effects of hCG-hMG treatment in 13 boys with pituitary dwarfism associated with gonadotropin deficiency, were assessed. " 06/01/1981 - "Females with pituitary dwarfism of the multiple pituitary hormone deficiency form have ovarian failure due to hypogonadotropism which would be expected to respond favorably to human gonadotropin treatment. " 04/01/1992 - "Combined human chorionic gonadotropin (HCG) and human menopausal gonadotropin (HMG) treatment in gonadotropin-deficient males with pituitary dwarfism." 06/01/1981 - "This is a description of a pituitary dwarf in whom pregnancy was achieved with gonadotropin therapy; its progress was followed regularly by hormone assays." 03/01/1990 - "Using pulsatile LH-RH administration, ovulation induction was performed in women with pituitary dwarfism (PD, n = 1), isolated gonadotropin deficiency (IGD, n = 5), secondary hypothalamic amenorrhea (gestagen negative (AM2, n = 10), positive (AM1, n = 5)), polycystic ovarian disease (PCO, n = 6) and anovulatory cycle (ANOV, n = 1). "
3.	Growth Hormone (Somatotropin)IBA 12/01/1985 - "In the last decade this work culminated in the close study of the Little Mouse with isolated growth hormone deficiency--thus exposing the panhypopituitary model (the human pituitary dwarf, Snell Smith mouse or hypophysectomised rat) as non-optimal models. " 05/01/2012 - "Individuals with growth hormone deficiency develop pituitary dwarfism with disproportionate delayed growth of skull and facial skeleton giving them a small facial appearance for their age. " 12/10/2009 - "A Chinese family with autosomal recessive pituitary dwarfism was identified and the proband was evaluated by MRI and hormonal analysis, which revealed pituitary dwarfism with a complete growth hormone deficiency. " 03/01/2008 - "Pituitary dwarfism causes short stature due to partial or complete inhibition of growth hormone (GH) secretion. " 04/01/2006 - "The patient had no central nervous disturbance, was diagnosed with pituitary dwarfism during childhood and was treated at another hospital with growth hormone supplement from 5 to 14 years of age. "
4.	Human Growth Hormone (Saizen)FDA LinkGeneric 01/01/1975 - "The study has aimed at investigating the blastic transformation of peripheral blood lymphocytes in patients with pituitary dwarfism before, during and after the treatment with human growth hormone. " 07/01/1965 - "[Study of the effects of human growth hormone in a patient with pituitary dwarfism]." 10/01/1964 - "RESISTANCE TO HUMAN GROWTH HORMONE IN PITUITARY DWARFISM: CLINICAL AND IMMUNOLOGIC STUDIES." 02/01/2004 - "(1) We reported on the head hair concentration of the above-mentioned elements from pituitary dwarfism (human growth hormone deficient) patients. " 04/01/1987 - "Treatment of pituitary dwarfism with authentic recombinant human growth hormone (SM-9500)."
5.	Somatomedins (Somatomedin)IBA 09/01/1975 - "Pituitary dwarfism in german shepherd dogs: studies on somatomedin activity." 01/01/1981 - "Inasmuch as the medium was supplemented with 10% fetal calf serum, which presumably contains somatomedin, these data suggest that the Dw/Dw mutant cannot be considered simply a model for pituitary dwarfism. " 01/01/1976 - "Pituitary dwarfism is a genetically heterogeneous group of disorders associated with a variety of pathogenetic mechanisms which may involve any level of the hypothalamic-pituitary-somatomedin-peripheral tissue axis. " 07/01/1963 - "Sulfation factor measurement as an aid in the recognition of pituitary dwarfism." 10/20/1984 - "[Somatomedin (bioassay) response to long-term growth hormone treatment of idiopathic pituitary dwarfism]."
6.	Growth Hormone-Releasing Hormone (Somatotropin Releasing Hormone)IBA 03/01/1988 - "Secretion of growth hormone-releasing hormone in patients with idiopathic pituitary dwarfism and acromegaly." 01/01/1987 - "[Effect of somatocrinin (GRF) on the secretion of growth hormone in pituitary dwarfism]." 12/01/1984 - "Plasma growth hormone responses to repetitive administrations of growth hormone releasing factor in patients with pituitary dwarfism." 01/01/1976 - "Further pathologic studies of the hypothalamus and pituitary in pituitary dwarfism; analysis of growth hormone and somatomedin cellular receptors; and elucidation of the structure of growth hormone releasing factor and techniques for its synthesis and assay should allow for the delineation of the specific pathogenetic mechanism in each of these syndromes."
7.	Pituitary HormonesIBA 01/01/1991 - "The purpose of this study was to determine whether the MR findings of idiopathic pituitary dwarfism correlated with a clinical history of perinatal abnormalities and abnormal levels of pituitary hormones. " 03/20/1995 - "The possibility of pituitary dwarfism during her youth and a gradual postpartum reduction of other pituitary hormones may have caused an impairment of the hypothalamo-pituitary-adrenal axis."
8.	GhrelinIBA 08/01/2006 - "Ghrelin-stimulation test in the diagnosis of canine pituitary dwarfism." 08/01/2006 - "This study investigated whether ghrelin, a potent releaser of growth hormone (GH) secretion, is a valuable tool in the diagnosis of canine pituitary dwarfism. "
9.	Dehydroepiandrosterone SulfateIBA 09/20/1981 - "[The study of serum dehydroepiandrosterone sulfate levels in normal children and children with pituitary dwarfism (author's transl)]."
10.	Nonesterified Fatty Acids (NEFA)IBA 12/01/1963 - "[STUDY OF THE PLASMA FREE FATTY ACIDS IN HYPOTHALAMO-PITUITARY NANISM TREATED AND UNTREATED BY GROWTH HORMONE]."

Therapies and Procedures

1.	Cesarean Section (Caesarean Section) 01/01/2010 - "Sub arachnoid block for emergency cesarean section in a pituitary dwarf." 07/01/1998 - "Anesthesia for cesarean section in a pituitary dwarf."
2.	Colonic Pouches (S Pouch) 07/01/1980 - "Pituitary dwarfism in the 13-month-old bitch can be ascribed to the persistence of one end of the ductus craniopharyngeus, Rathke's pouch. "
3.	Osteotomy 07/01/2008 - "Among 54 patients (male 28, female 26, mean age 22) who performed tibial lengthening by metaphyseal osteotomy using two-axis parallel method, 26 patients were poliomyelitis sequelae, 13 patients were inequality in limb length after trauma, 4 patients were achondroplasia, 6 patients were genetic short stature, 1 patient was maculatum disease complicated with leg length discrepancy, 4 patients were pituitary dwarfism. "
4.	Intramuscular Injections 01/01/1987 - "Plasma hGH reached peak levels at 3 hours after intramuscular injection of recombinant somatropin, 4 IU, and this peak value was 57.3 +/- 2.8 ng/ml. A total of 21 patients with pituitary dwarfism were also treated with recombinant somatropin for 6 months at a dose of 0.5 IU/kg/week. "
5.	Anesthesia 07/01/1998 - "Anesthesia for cesarean section in a pituitary dwarf."