Galactitol

A naturally occurring product of plants obtained following reduction of GALACTOSE. It appears as a white crystalline powder with a slight sweet taste. It may form in excess in the lens of the eye in GALACTOSEMIAS, a deficiency of GALACTOKINASE.

Also Known As:

Networked: 86 relevant articles (2 outcomes, 6 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Yager, Claire: 4 articles (07/2010 - 02/2005)
2.	Segal, Stanton: 4 articles (04/2006 - 08/2002)
3.	Segal, S: 4 articles (08/2001 - 07/2000)
4.	Ficicioglu, Can: 3 articles (07/2010 - 02/2005)
5.	Ning, C: 3 articles (02/2001 - 07/2000)
6.	Lim, Soon Sung: 2 articles (09/2013 - 01/2013)
7.	Thomas, Nina: 2 articles (07/2010 - 12/2008)
8.	Hussa, Christie: 2 articles (07/2010 - 12/2008)
9.	Gallagher, Paul R: 2 articles (07/2010 - 12/2008)
10.	Yager, Claire T: 2 articles (11/2003 - 08/2002)

Related Diseases

1.	Cataract (Cataracts) 02/01/2001 - "Increased plasma galactitol levels may lead to development of bilateral pediatric cataract. " 07/22/2000 - "In humans, GK deficiency results in congenital cataracts due to an accumulation of galactitol within the lens. " 10/01/1999 - "Cataract-formation in this family is most likely due to a defect in the galactitol pathway, e.g. " 10/01/1999 - "[Familial cataract in plasma galactitol increase without known enzyme defect]." 01/01/1993 - "The correlation between dulcitol accumulation and cataract development is discussed."
2.	Diabetes Complications 09/01/2013 - "Furthermore, methyl-3,5-di-O-caffeoylquinate inhibited galactitol formation in the rat lens and in erythrocytes incubated with a high concentration of glucose, indicating that this compound may be effective in preventing diabetic complications." 09/26/1983 - "Galactitol accumulation by glucose-6-phosphate deficient fibroblasts: a cellular model for resistance to the complications of diabetes mellitus." 09/01/2013 - "As part of our ongoing search for natural sources of therapeutic and preventive agents for diabetic complications, we evaluated the inhibitory effects of components of the fruit of Xanthium strumarium (X. strumarium) on aldose reductase (AR) and galactitol formation in rat lenses with high levels of glucose. " 01/01/1991 - "This investigation demonstrated that in two models of diabetic complications, streptozocin (STZ)-induced diabetic rats and galactose-fed rats, 5 weeks of disease led to an accumulation of sorbitol or galactitol, respectively, in three cranial nerves (the optic (II), trigeminal (V), and vagus (X) nerves), as well as the sciatic nerve, cerebral cortex, and retina. "
3.	Galactosemias (Galactosemia) 12/01/2008 - "RBC gal-1-p and urine galactitol were monitored during the follow-up visits in every child with DG galactosemia. " 02/01/2005 - "Galactitol and galactonate in red blood cells of children with the Duarte/galactosemia genotype." 08/01/2001 - "The results demonstrate that a markedly elevated brain galactitol level may be present only in newborn infants with galactosemia who exhibit massive urinary galactitol excretion." 02/01/2001 - "In vivo evidence of brain galactitol accumulation in an infant with galactosemia and encephalopathy." 10/01/1999 - "Urinary excretion of galactitol was determined in 95 normals (N/N), 67 galactosemic (G/G), and 39 compound heterozygotes for the Duarte and galactosemia genotype (D/G). "
4.	Edema 08/19/1985 - "Experimental galactose neuropathy (EGN) was chosen since in this model, edema is due to the accumulation of galactitol, which does not directly damage nerve fibers, so that it was possible to study the role of endoneurial edema alone. " 01/01/1981 - "There was no evidence of edema in Schwann cell cytoplasm, the putative site of galactitol accumulation via the sorbitol pathway. " 03/01/1986 - "Feeding galactose to rats induces nerve conduction abnormalities, increased levels of nerve galactitol, endoneurial edema, elevated pressure and hypoxia of endoneurial fluid, and pathological abnormalities of nerve fibers. " 01/01/1993 - "Galactose cataracts have been associated with lens edema attributed to the osmotic stress of tissue polyol (galactitol) accumulation. "
5.	Neoplasms (Cancer) 02/01/1990 - "Autoradiographic studies of labeled diacetyldianhydro-galactitol (DADAG) with tumor bearing animals revealed that the CNS accumulates high amounts of DADAG-derived radioactivity and the elimination from the brain seems to be relatively slow. " 01/01/1981 - "The effect of dibromo-dulcitol and dianhydro-dulcitol (galactitol) on RNA synthesis in ascites tumor cells."

Related Drugs and Biologics

1.	Galactose (Galactopyranose)
2.	sorbinil
3.	Glucose (Dextrose)
4.	Sorbitol (Yal)
5.	Lactose
6.	Inositol (Myoinositol)
7.	Mannitol (Osmitrol)
8.	Sugar Alcohols
9.	Polysaccharides
10.	Oligosaccharides

Related Therapies and Procedures

1.	Lenses
2.	Absorbable Implants
3.	Injections
4.	Diet Therapy (Therapy, Diet)
5.	Aftercare (After-Treatment)