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Pentetic Acid (DTPA)

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An iron chelating agent with properties like EDETIC ACID. DTPA has also been used as a chelator for other metals, such as plutonium.

Also Known As:

DTPA; calcium trisodium pentetate; Indium-DTPA; Ca-DTPA; CaDTPA; CaNa-DTPA; DETAPAC; Mn-Dtpa; Pentacin; Pentacine; Pentaind; Sn-DTPA; Zinc-DTPA; Acid, Diethylenetriamine Pentaacetic; Ca DTPA; CaNa DTPA; Indium DTPA; Mn Dtpa; Pentaacetic Acid, Diethylenetriamine; Sn DTPA; Zinc DTPA; Diethylenetriamine Pentaacetic Acid; Pentetates; Penthanil; Glycine, N,N-bis(2-(bis(carboxymethyl)amino)ethyl)-

Networked: 1319 relevant articles (84 outcomes, 232 trials/studies)

Relationship Network

Drug Context: Research Results

Organic Chemicals: 58
- Amines: 1422
  - Polyamines: 1386
    - Pentetic Acid: 1319
- Carboxylic Acids: 83
  - Acyclic Acids
    - Acetic Acids: 20
      - Pentetic Acid: 1319
        Gadolinium DTPA: 2047
        Technetium Tc 99m Pentetate: 59
        Indium 111In-satumomab pendetide: 44
        N-(2-amino-3-(4-isothiocyanatophenyl)propyl)cyclohexane-1,2-diamine-N,N',N',N'',N''-pentaacetic acid: 25
        sprodiamide: 12
        cyclic DTPA anhydride: 10
        gadolinium N-(2-butyryloxyethyl)-N'-(2-ethyloxyethyl)-N,N'-bis(N'',N''-bis(carboxymethyl)acetamido)-1,2-ethanediamine: 7
        benzyl-DTPA: 6
        DTPA folate: 6
        technetium-diethylenetriaminepentaacetic acid-mannosyl-dextran: 6
        1-(4-isothiocyanatobenzyl)diethylenetriaminepentaacetic acid: 5
        111In-DTPA-human epidermal growth factor: 5
        2-(4-isothiocyanatobenzyl)-6-methyldiethylenetriaminepentaacetic acid: 5
        SDZ 215-811: 5
        6-(4-isothiocyanatobenzyl)-diethylenetriamine pentaacetic acid: 4
        dysprosium DTPA: 4
        glycyl-tyrosyl-lysine-DTPA: 4
        DTPA pentetreotide: 3
        1,3-bis(N-(N-(2-aminoethyl)-2-aminoethyl)-2-aminoacetamido)-2-(4-isothiocyanatobenzyl)propane-N,N,N',N'',N''',N'''',N''''',N'''''-octaaceticacid: 2
        111In-DTPA-N-TIMP-2: 2
        188Re-DTPA-deoxyglucose: 2
        bis(MSH)-DTPA: 2
        dysprosium ethoxybenzyl DTPA: 2
        ytterbium DTPA: 2
        111In-benzyl-DTPA-ZHER2:342: 1
        111indium-DTPA-Ac-TZ14011: 1
        2-(p-isothiocyanatobenzyl)-1,4,7,10,13-pentaazacyclopentadecane-N,N',N'',N''',N''''-pentaacetic acid: 1
        alpha,omega-(bis)DTPA-biocytin: 1
        AMD 6221: 1
        biotin-BSA-GdDTPA: 1
        diethylenetriaminetetraacetic acid: 1
        DTPA(0)- 111In-octreotide: 1
        DTPA-B2: 1
        DTPA-methotrexate: 1
        DTPA-Nle(4)-Phe(7)- alpha-MSH: 1
        gadolinium-DTPA-g-mimRGD: 1
        gadolinium-N,N-bis(2-(bis(carboxymethyl)(3-(4-mannopyranosyloxy-3-(3-carboxymethylphenyl)phenyl)propyl)amino)ethyl)glycine: 1
        indium benzyldiethylenetriaminepentaacetic acid: 1
        indium-111-DTPA-CTT: 1
        N-alpha-DTPA-tyrosyl-N-epsilon-DTPA-lysine: 1
        technetium 99m DTPA-bis(methionine): 1
        (111)In-Fab-DTPA antimyosine
        (111)indium-DTPA-D-phe octreoide
        1-(4-aminobenzyl)-4-methyl-DTPA
        1-(4-aminobenzyl)-DTPA
        111In-CHX-A''-DTPA-Z(HER2;342) affibody
        111In-diDTPA-FKYK
        2-(4-isothiocyanatobenzyl)diethylenetriaminepentaacetic acid
        4-(N-maleimidomethyl)cyclohexane-1-carbonyllysyl(4-(N-maleimidomethyl)cyclohexane-1-carbonyl)-lysyl(1-((4-thiocarbonylamino)benzyl)diethylenetriaminepentaacetic acid)-tyrosyl-lysine(1-((4-thiocarbonylamino)benzyl)diethylenetriaminepentaacetic acid)
        90Y-CHX-A''-DTPA-hu3S193
        Ac-D-Phe-D-Lys(DTPA)-D-Tyr-D-Lys(DTPA)-NH2
        asialofetuin-DTPA complex
        bovine serum albumin-DTPA complex
        cellulose-1,6-diaminohexane-DTPA
        Cy5.5-DTPA-galactosyl-dextran
        cyclo(Arg-Gly-Asp-Tyr-Lys)-DTPA
        cyclohexyldiethylenetriamine pentaacetic acid
        diethylenetriamine N-hydroxysuccinimide pentaester
        diethylenetriamine-N'-methylene(p-aminobenzyl)phosphinic-N,N,N'',N''-tetraacetic acid gadlinium complex
        diethylenetriamine-N,N''-bis(acetyl-isoniazid)-N,N',N''-triacetic acid
        diethylenetriaminepentaacetic acid stearylamide
        diethylenetriaminepentaacetic acid-inulin
        DOPE YAS
        DTPA bis((Nle(4)-Phe(7))-alpha-MSH)
        DTPA bis(methoxyethylamide)
        DTPA bis(N-ethanolamide-N-methoxyethylamide)
        DTPA bis(N-methoxyethylamide-N-methylamide)
        DTPA copolymer
        DTPA ferric chelate
        DTPA ferrous chelate
        DTPA(1)-Lys(3),Tyr(4)bombesin
        DTPA-benzyl-acetamido-D-Phe(1),Tyr(3)-octreotide
        DTPA-bis-biotin
        DTPA-CHD
        DTPA-Gly(pip)-Pro-Gly(PipAm)-Arg-Pro-Tyr-tBuGly-Leu
        DTPA-heparin
        DTPA-HMD
        DTPA-IgG complex
        DTPA-Pro(1),Tyr(4)bombesin
        dysprosium diethylenetriamine pentaacetic acid dimeglumine
        europium DTPA-cs124
        Evans blue-DTPA-gadolinium
        formyl-norleucyl-leucyl-phenylalanyl-norleucyl-tyrosyl-lysine-DTPA
        gadolinium (DTPA-bis(aminoethoxy)etane) polymer
        gadolinium(III) diethylenetriamine-N'-(3-amino-1,1-propylenephosphonic)-N,N,N'',N''-tetraacetate
        gadolinium-DTPA cystine copolymer
        gadolinium-DTPA cystine diethyl ester copolymer
        Gd-DTPA L-cystine bisamide copolymer
        holmium-166-DTPA
        indium 1-(4-isothiocyanatobenzyl)diethylenetriaminepentaacetic acid
        indium DTPA-adriamycin
        indium DTPA-albumin
        indium DTPA-bis(stearylamide)
        indium DTPA-epsilon-lysine
        indium DTPA-Glu-G-CCK8
        indium DTPA-RC-160
        Indium-111-DTPA-Arg(1)- substance P
        isothiocyanate-benzyl-DTPA
        lactoferrin-DTPA-Eu conjugate
        methoxy-polyethylene glycol-succinyl-polylysine-GdDTPA

Experts

1.	Krenning, Eric P: 18 articles (05/2014 - 04/2002)
2.	Boerman, Otto C: 11 articles (08/2015 - 09/2003)
3.	Reilly, Raymond M: 11 articles (06/2015 - 04/2004)
4.	de Jong, Marion: 10 articles (05/2014 - 12/2002)
5.	Schuerman, Lode: 9 articles (01/2014 - 11/2002)
6.	Goldenberg, David M: 9 articles (02/2010 - 01/2003)
7.	Oyen, Wim J G: 8 articles (08/2015 - 09/2003)
8.	Jacquet, Jeanne-Marie: 8 articles (08/2011 - 01/2005)
9.	Bock, Hans L: 8 articles (06/2011 - 10/2003)
10.	Kwekkeboom, Dik J: 7 articles (09/2012 - 04/2002)

Related Diseases

1.	Neoplasms (Cancer) 03/25/1992 - "The daily administration of DTPA to the mice after injection of In-MoAb reduced radioactivity in the normal tissues, especially in the liver after the second day, and improved tumor to normal tissue ratios. " 08/01/2009 - "The K(d) of 111In-[DTPA(1), Lys(3), Tyr(4)]-BN in GRPR-expressing PC-3 tumor cells was 22.9 +/- 6.81 nM. Both biodistribution and micro-SPECT/CT (single-photon emission computed tomography/computed tomography) imaging studies with 111In-[DTPA(1), Lys(3), Tyr(4)]-BN demonstrated the highest uptake at 8 hours postinjection. " 01/01/2009 - "In bio-distribution studies we found (213)Bi-DTPA-[F3](2) to accumulate in tumors but only low activities were found in control organs except for the kidneys, where (213)Bi-DTPA-[F3](2) is found due to renal excretion. " 01/01/2009 - "In a tumor reduction study between the days 16-26 after inoculation of tumor cells 6x1.85 MBq of (213)Bi-DTPA-[F3](2) were injected. " 01/01/2009 - "In a tumor prevention study between the days 4-14 after inoculation of tumor cells 6x1.85 MBq (50 microCi) of (213)Bi-DTPA-[F3](2) were injected. "
2.	Whooping Cough (Pertussis) 08/05/2011 - "The study was designed to determine the feasibility of implementing routine dTpa vaccination in the maternity ward to new mothers and to assess midwives' attitudes toward pertussis booster vaccination, their perceived susceptibility and severity of pertussis in their patients' communities, the perceived barriers and benefits of their patients' vaccinations, and their cues to action and self-efficacy in delivering the vaccine. " 10/13/2015 - "In our setting, vaccinating parents with dTpa during the four weeks following delivery did not reduce pertussis diagnoses in infants. " 10/13/2015 - "During a pertussis epidemic in 2011-2012 the Western Australian (WA) Department of Health implemented a 'cocooning' programme, offering free pertussis-containing vaccine (dTpa) to new parents. " 01/01/2011 - "This document is the result of a meeting in Mexico City of international experts who analyzed recent medical information in order to establish the current status of the epidemiology, diagnosis and surveillance of pertussis and, especially, the value of the dTpa booster dose in adolescents and adults as a pertussis prevention strategy in Mexico." 08/12/2008 - "However, a three-pertussis-component DTPa vaccine containing PT, FHA and a recombinant BrkA protein (rBrkA) was found to be as efficacious in protecting mice against colonization by B. "
3.	Lung Injury 03/20/1993 - "Clearance of aerosolized DTPA from airspaces, although extremely sensitive, is not specific for ARDS in as much as factors other than lung injury may equally affect the rate of DTPA clearance from the lung. " 02/01/2001 - "A DTPA clearance test is sensitive for the early detection of radiation lung injury and seems helpful for clarifying the association of epithelial integrity changes and lung surfactant in radiation lung injury." 02/01/2001 - "The alteration of 99mTc-labeled diethylenetriaminepentaacetic acid (DTPA) transalveolar clearance in an initial phase of radiation lung injury was experimentally investigated. " 09/01/1996 - "The clearance rate of an inhaled aerosol of 99mTc-diethylenetriaminepenta-acetic acid (DTPA) was used as a marker of lung injury. " 10/01/1991 - "From these groups, one nonsmoker and 11 cigarette smokers displayed biexponential 99mTc DTPA clearances, indicative of greater lung injury than found in the usual cases of monoexponential clearance. "
4.	Diphtheria 05/01/2008 - "Anti-diphtheria and anti-PRN concentrations were higher after DTPa, but groups differences reduced over time. " 12/02/2004 - "Therefore, the difference observed in diphtheria antibody geometric mean concentrations 1 month after booster vaccination at 4-6 years with dTpa or DTPa is unlikely to be of clinical relevance 10 years later at the time of the adolescent booster." 12/02/2004 - "When applied to data collected 3.5 years after vaccination of 4-6 year olds with either DTPa or dTpa, the model predicted that 10 years post-vaccination, 98.6% of subjects vaccinated with dTpa were likely to remain seroprotected against diphtheria, compared to 99.6% vaccinated with DTPa. " 12/02/2004 - "However, anti-diphtheria antibody levels were observed to be lower when compared to the "full strength" paediatric DTPa vaccine. " 12/02/2004 - "Anti-diphtheria antibody seroprotection rates are similar 10 years after vaccination with dTpa or DTPa using a mathematical model."
5.	Neoplasm Metastasis (Metastasis) 01/01/1998 - "On the basis of our data, Sn-117m DTPA should be an effective and safe radiopharmaceutical for palliation of painful bony metastases. " 08/01/2015 - "Based on this study, we believe that HA-DTPA-Gd has promising potential for use as a contrast agent for liver MRI of hepatic metastases." 08/01/2015 - "HA-DTPA-Gd, which possessed a higher T1 relaxivity, showed excellent capability for the diagnosis of hepatic metastasis through an in vivo MRI study in comparison with gadoxetic acid (p < 0.001). " 06/01/1996 - "We assessed the clinical significance of interruption of CSF flow documented by radionuclide ventriculography (111Indium-DTPA CSF flow study) in patients with leptomeningeal metastases. " 01/01/1998 - "Forty-seven patients with painful bone metastases from various malignancies were treated with Sn-117m DTPA. "

Related Drugs and Biologics

1.	Gadolinium
2.	Octreotide (Sandostatin)
3.	Pentetic Acid (DTPA)
4.	Technetium (Technetium 99m)
5.	Vaccines
6.	Gadolinium DTPA (Magnevist)
7.	Smoke
8.	Acetic Acid (Vinegar)
9.	PENTA
10.	Chelating Agents

Related Therapies and Procedures

1.	Radioimmunotherapy
2.	Transplants (Transplant)
3.	Injections
4.	Microspheres (Microsphere)
5.	Homologous Transplantation (Allograft)