Drug Hypersensitivity (Drug Allergy)

08/01/2014 - "In vitro diagnosis of immediate IgE-mediated drug hypersensitivity: warnings and (unmet) needs."
06/01/2014 - "Skin testing and patch testing in non-IgE-mediated drug allergy."
03/01/2014 - "Taken together, these results establish the HBI design as a broadly applicable platform with therapeutic potential for the targeted and selective inhibition of IgE-mediated allergic responses, including food, environmental, and drug allergies. "
01/01/2013 - "Insights on the pathophysiology and diagnosis of non-IgE-mediated drug allergy are offered, with novel data regarding the interaction of drugs with HLA molecules. "
02/01/2012 - "In immediate, immunoglobulin E-mediated drug hypersensitivity, this kind of approach remains rather confidential. "

03/01/2014 - "Drug provocation tests (DPTs) are gold standard to diagnose drug allergy. "
01/01/2011 - "Although still controversial, drug provocation tests (DPTs) are considered by many as the gold standard for diagnosis of drug hypersensitivity. "
04/01/2013 - "The aim of this study was to review the patients that underwent drug provocation tests (DPTs) in our centre and examine the usefulness of DPTs in confirming or rejecting a diagnosis of drug hypersensitivity. "
03/01/2014 - "Our results suggest that a positive clinical history is not enough to make a diagnosis of drug allergy, which highlights the significance of undertaking further diagnostic evaluation especially for DPTs. "
01/01/2013 - "However, the field of drug allergy is changing and DPTs make no exception. "

01/01/2014 - "Spontaneously reported three cases of AHS-drug hypersensitivity reactions induced by carbamazepine are discussed here. "
01/01/2005 - "Carbamazepine is one of the common drugs that have been implicated in the etiology of drug hypersensitivity syndrome. "
03/01/2000 - "A 17-year-old female is presented who developed antiepileptic drug hypersensitivity syndrome after treatment with carbamazepine. "
03/01/2012 - "A provisional diagnosis of drug hypersensitivity syndrome to carbamazepine was made with a differential diagnosis of viral exanthema with systemic complications. "
08/01/2003 - "Drug hypersensitivity syndrome to carbamazepine and human herpes virus 6 infection: case report and literature review."

03/01/1957 - "[Experimental and clinical studies on the problem of drug allergy, with special regard to the chemical structure of the allergens]."
03/01/1986 - "The findings suggest that the incidence rates of occupational drug allergy were dependent on the frequencies and concentration of exposure to allergens."
07/01/1984 - "Drug allergy: incidence in terms of age and some drug allergens."
09/01/2013 - "A quantitative analysis was also performed to compare the content coverage of each terminology for (1) common food, drug, and environmental allergens and (2) descriptive concepts for common drug allergies, adverse reactions (AR), and no known allergies. "
01/01/2012 - "Drug allergy comprises 10% to 30% of all adverse drug reactions, and according to data from the literature, sensitivity to drug allergens is 2 to 3 times more common in health care workers than in the general population. "

03/01/2014 - "Cross-reactivity to Acetaminophen and Celecoxib According to the Type of Nonsteroidal Anti-inflammatory Drug Hypersensitivity."
01/01/2002 - "The primary objectives of this study were to evaluate the safety and efficacy of the cyclooxygenase-2 inhibitor celecoxib in systemic lupus erythematosus (SLE) patients both with and without a self-reported sulfa drug allergy and to review the literature on the use of nonsteroidal agents in SLE subjects. "

01/01/2002 - "The primary objectives of this study were to evaluate the safety and efficacy of the cyclooxygenase-2 inhibitor celecoxib in systemic lupus erythematosus (SLE) patients both with and without a self-reported sulfa drug allergy and to review the literature on the use of nonsteroidal agents in SLE subjects. "

01/30/2014 - "Although individual susceptibilities to adverse effects differ among patients, abacavir is associated with idiosyncratic hypersensitivity drug reactions and an increased risk of cardiac dysfunction. "
03/23/2004 - "Susceptibility to a clinically significant drug hypersensitivity syndrome associated with abacavir use seems to have a strong genetic component. "
12/01/2001 - "Understanding drug hypersensitivity: what to look for when prescribing abacavir."
06/01/2011 - "This review examines the place of interventional epidemiology in the field of drug allergy, taking as examples both myorelaxant-induced anaphylaxis and abacavir-induced DRESS."
01/01/2014 - "Drug hypersensitivity syndromes such as abacavir hypersensitivity and the severe cutaneous adverse drug reactions have been associated with significant short- and long-term morbidity and mortality. "

12/01/1984 - "Bronchoalveolar lavage in acute drug-hypersensitivity pneumonitis probably caused by phenytoin."
06/01/2009 - "Phenytoin, one of the most common antiepileptic drugs, is a major cause of antiepileptic drug hypersensitivity syndrome (AHS), which is a rare but potentially fatal complication. "
08/01/2006 - "Drug hypersensitivity to previously tolerated phenytoin by carbamazepine-induced DRESS syndrome."
12/01/2005 - "The safe clinical use of phenytoin (PHT) is compromised by a drug hypersensitivity reaction, hypothesized to be due to bioactivation of the drug to a protein-reactive metabolite. "
01/01/1987 - "With carbamazepine and phenytoin, hepatotoxicity may be due to drug hypersensitivity. "

02/01/2011 - "In this paper the authors aim to summarize the current state of the art in immunotherapy in the treatment of inhalant, venom and drug allergies, with specific reference to its practice in the United Kingdom. "
06/01/1999 - "228 consecutive inpatients with insect venom allergies (ins), food intolerance (food), drug hypersensitivities (dru) and urticaria (urt) were evaluated by validated questionnaires regarding psychological strain and motivation for psychosocial treatments. "
04/01/2011 - "Desensitization is a therapeutic modality for drug allergy (similar to allergen specific immunotherapy for allergic rhinitis and insect venom anaphylaxis). "
07/01/2011 - "In table form, we compared the signs and symptoms of the most common outpatient consultations to an allergist's office practice (chronic rhinitis, asthma, food allergy, venom allergy, atopic dermatitis, drug allergy, chronic urticaria, acute urticaria, immunodeficiency, and anaphylaxis) with those of likely bioterrorism threats. "
01/01/2009 - "The most common reasons for consultation included 808 (57.2%) patients for chronic rhinitis, 288 (20.4%) for asthma, 196 (13.9%) for food allergy, 89 (6.3%) for venom allergy, 68 (4.8%) for atopic dermatitis, 66 (4.7%) for drug allergy, 62 (4.4%) for chronic urticaria, 45 (3.2%) for acute urticaria, 34 (2.4%) for immunodeficiency, 31 (2.2%) for anaphylaxis, and 162 (11.5%) for other reasons. "

05/01/2006 - "Skin testing for drug hypersensitivity is a valuable diagnostic tool and a well established procedure for betalactams and corticosteroids. "
10/01/1992 - "Both patients were premedicated with corticosteroids and neither reported prior drug allergies. "
10/01/2012 - "Children with AR were more likely to require adjunct therapy with inhaled corticosteroids (51.2% vs. 43.2%, P < 0.001), have drug hypersensitivity (especially antipyretic drugs) (2.5% vs. 1.3%, P = 0.384) or an asthma admission (9.1% vs. 6.0%, P < 0.001). "
01/01/2011 - "Additional therapy for drug hypersensitivity reactions is largely supportive and may include topical corticosteroids, oral antihistamines and, in severe cases, systemic corticosteroids. "
05/01/2006 - "The aim of the present report is to describe four adolescents with antiepileptic drug hypersensitivity syndrome who were treated with intravenous immunoglobulin and systemic corticosteroids. "

09/01/1979 - "On the basis of the present findings, immunotherapy in drug allergy is possible and should not present any special problems: it is necessary that the treatment be carried out by highly qualified staff and preferably on hospitalized patients."
12/01/2012 - "The clinical allergy section focuses on drug allergy, food allergy and immunotherapy. "
02/01/2011 - "In this paper the authors aim to summarize the current state of the art in immunotherapy in the treatment of inhalant, venom and drug allergies, with specific reference to its practice in the United Kingdom. "
04/01/2011 - "Desensitization is a therapeutic modality for drug allergy (similar to allergen specific immunotherapy for allergic rhinitis and insect venom anaphylaxis). "
03/01/2003 - "Among the topics highlighted: Epinephrine injected intramuscularly into the thigh provides the most efficient absorption profile for adults and children; determination of serum IgE antibody-specific food allergen concentrations and atopy patch tests with foods show promise for enhanced diagnostic accuracy; numerous food allergens are now characterized on the molecular level, allowing for improved diagnostic and treatment modalities; the complex immunologic mechanisms underlying drug hypersensitivity reactions are being elucidated; venom immunotherapy improves quality of life for sufferers, and increased venom immunotherapy doses are useful in recalcitrant cases."

05/01/2009 - "Although corticosteroids and intravenous immunoglobulin have both been used as immunomodulatory therapy, there is no robust evidence supporting the efficacy of their therapy for drug hypersensitivity. "

01/01/2015 - "Cytokine release syndrome from rapid cell lysis was the likely cause as infectious workup failed to reveal a definitive etiology and drug hypersensitivity testing to the chemotherapy agents was negative. "
01/01/2014 - "Before the arrival of modern pharmacotherapy, drug hypersensitivity reactions were virtually unknown. "
01/01/2014 - "The recognition of "first-line" chemotherapy and monoclonal agents for these conditions has given more urgency to the need to re-administer these drugs in cases of drug hypersensitivity reactions. "
07/01/2013 - "Drug hypersensitivity may deprive patients of drug therapy, and occasionally no effective alternative treatment is available. "
01/01/2011 - "These interventions were performed in order to clarify differences in medical records regarding drug allergies or intolerances (n=111), to identify pharmacotherapy discrepancies between acute and chronic treatment (n=118), to identify opportunities for improving pharmacotherapy (n=263), and upon discharge in order to educate the patient about his/her treatment (n=31) and to dispense limited duration drugs (n=1186). "

07/01/1992 - "Three patients had a clinical history of drug allergy, and two had a clinically documented drug reaction prior to transplant. "
01/01/2002 - "Patients who exhibited an adverse reaction to OsteoSet and those who did not were analyzed for statistical differences with respect to age, sex, volume of graft material used, size of pellet, use of alcohol washes, mixing of OsteoSet with allograft, medications, drug allergies, and smoking history. "
08/01/2012 - "There was no history of any concomitant medications, drug allergy, burn injury, recent graft, or transplant or any coexisting infections such as herpes simplex. "
09/01/2009 - "A hematopoietic stem cell transplant patient with a history of immediate drug hypersensitivity reaction to micafungin was considered for a caspofungin trial. "

08/01/2009 - "These results will provide the basic data in the further study in transplantations, genetic association with diseases, and drug hypersensitivity."
08/01/2015 - "In 2013, the Division of Allergy, Immunology, and Transplantation of the National Institute of Allergy and Infectious Diseases sponsored a workshop on drug allergy. "
01/01/2015 - "However, differentiation between acute cutaneous GVHD and other common skin eruptions that develop in the post-transplantation period, such as drug hypersensitivity reaction, can be challenging clinically and microscopically. "
09/01/2014 - "In 22 patients, atopic diseases [allergic rhinitis in nine patients (5.5%), asthma in six patients (3.9%), atopic eczema in six patients (3.9%), food allergy in six patients (3.9%), and drug allergy in one patient (0.6%)] developed after transplantation. "