Drug Combinations

01/01/2023 - "These results demonstrate a procedure to identify which combination drug dose schedules could be most effective in eliminating drug resistant cancer cells. "
12/01/2020 - "The results indicated that even when working through different mechanisms, combining drugs that initiate a similar transcriptional response may constitute the best option for determining drug-combination strategies for the treatment of cancer."
01/01/2020 - "The scheduled delivery of synergistic drug combinations is increasingly recognized as highly effective against advanced solid tumors. "
01/01/2018 - "To our knowledge, this is the first time that this approach to the high-throughput analysis of chaperone inhibitors has been applied, and it can be useful in the search for drug combinations that are effective in the treatment of highly resistant tumors."
01/01/2014 - "A multifunctional drug combination shows highly potent therapeutic efficacy against human cancer xenografts in athymic mice."

01/01/2023 - "Another challenge is determining which drug combinations are most effective against NTM infection. "
11/01/2019 - "Here we use phospho-specific flow cytometry to assess perturbations of many different cellular signaling pathways during treatment with drug combinations that are highly effective in blocking Herpes simplex virus type 1 (HSV-1) infection. "
10/01/1986 - "In addition, available clinical evidence suggests that synergistic drug combinations are most effective in the treatment of infections due to Pseudomonas aeruginosa. "
03/01/2015 - "In order to develop improved drug combinations that effectively target diverse mycobacterial phenotypes, it is important to understand how such subpopulations of M.tb are formed during human infection. "
05/01/2008 - "In contrast, we demonstrate that a triple drug combination of IFN, RBV, and an iminosugar eradicated the BVDV infection in a time- and a dose-dependent manner, leading to sustained viral clearance. "

01/15/2012 - "Furthermore, the toxicity of this drug combination was significantly greater in SUM159 human breast cancer cells, relative to HMEC normal human breast epithelial cells. "
01/01/2009 - "The findings indicate that the 267/Dt drug combination confers increased (synergistic) therapeutic efficacy towards human breast cancer cells that express low levels of Her2."
11/08/2022 - "While breast cancer remains a global health concern, the elaboration of rationally designed drug combinations coupled with advanced biocompatible delivery systems offers new promising treatment venues. "
12/31/2017 - "Confocal microscopy studies evidently demonstrated that these novel nanoparticles can home into lysosomes in breast cancer cells, fragment subcellular nuclei, and prevent cell division, leading to improved breast cancer cell death compared to free drug combination. "
08/01/2004 - "Current trends in the treatment of human breast cancer are with drug combinations that result in improved responses as well as the ability to use less toxic concentrations of the drugs. "

02/01/1978 - "A drug combination was used against sub-lesional pain with some good results. "
10/03/2021 - "This drug combination improved the periodontal indexes and inflammatory reaction of CP and relieved their pain. "
01/01/2012 - "In the long run, only an Iberis amara drug combination relieved pain sufficiently. "
09/01/2009 - "The polyanalgesic initiative aims to summarize the current knowledge and to facilitate rational choices of intrathecal drug and drug combinations for the management of chronic pain. "
10/26/1991 - "The drug combination relieved pain within 30 seconds after injection and the relief lasted for 50 minutes in three of the ponies and for 20 minutes in the other two. "

09/01/2004 - "Although remarkable progress has been made on this topic in recent years, future studies aimed at assessing the sympathetic effects of combination drug treatment will be helpful in improving the clinical use of the association of two or more drugs in hypertension treatment."
08/01/2009 - "Guidelines recommend drug-drug combinations as a first-line treatment in high-risk patients with severe hypertension, or as an escalation for patients not controlled on monotherapy. "
01/01/2021 - "Effective treatment of hypertension is becoming an increasingly difficult process that often requires multiple drug combinations to meet target guidelines. "
05/01/2006 - "Fixed-drug combinations as first-line treatment for hypertension."
02/15/1995 - "Specifically, the drug combination prevented diastolic hypertension and improved aortic blood flow by normalizing peripheral resistances, abolished the vascular hyperpulsatile characters, and restrained the fragmentation and the splitting of elastic fibers in capacitance arteries. "