Drug Carriers

Forms to which substances are incorporated to improve the delivery and the effectiveness of drugs. Drug carriers are used in drug-delivery systems such as the controlled-release technology to prolong in vivo drug actions, decrease drug metabolism, and reduce drug toxicity. Carriers are also used in designs to increase the effectiveness of drug delivery to the target sites of pharmacological actions. Liposomes, albumin microspheres, soluble synthetic polymers, DNA complexes, protein-drug conjugates, and carrier erythrocytes among others have been employed as biodegradable drug carriers.

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Networked: 887 relevant articles (45 outcomes, 103 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Kwon, Ick Chan: 10 articles (11/2014 - 04/2008)
2.	Kim, Kwangmeyung: 9 articles (11/2014 - 04/2008)
3.	Bae, You Han: 9 articles (09/2014 - 05/2002)
4.	Park, Jae Hyung: 8 articles (01/2016 - 04/2008)
5.	Zhang, Xian-Zheng: 8 articles (08/2015 - 02/2008)
6.	Na, Kun: 7 articles (01/2016 - 05/2002)
7.	Zhuo, Ren-Xi: 7 articles (04/2014 - 02/2008)
8.	Choi, Kuiwon: 7 articles (12/2013 - 04/2008)
9.	Torchilin, Vladimir P: 7 articles (01/2010 - 12/2002)
10.	Lammers, Twan: 6 articles (06/2015 - 07/2009)

Related Diseases

1.	Neoplasms (Cancer) 07/01/2013 - "These data implied the promising potential of c-HANP as tumor-targeting drug carriers and demonstrated the remarkable effect of the improved stability upon the biodistribution and therapeutic efficacy of drug-loaded nanoparticles." 09/01/2006 - "These results strongly suggest that intratumoral distribution of drug carrier is much more important for therapeutic efficacy than the total accumulation of the anticancer drug in the tumor, and that active delivery of anticancer drugs to angiogenic vessels is useful for cancer treatment." 07/02/2010 - "Taken together, the novel CCMC self-assembled nanoparticles might have potential application as anti-cancer drug carriers in a drug delivery system due to good results in vitro and in vivo." 02/09/2015 - "The major issues of self-assembled nanoparticles as drug carriers for cancer therapy include biostability and tumor-targetability because the premature drug release from and nonspecific accumulation of the drug-loaded nanoparticles may cause undesirable toxicity to normal organs and lower therapeutic efficacy. " 11/01/2011 - "Nanoscale drug carriers are particularly attractive for cancer therapy because of their passive targeting effect to enhance the therapeutic efficacy of drugs. "
2.	Infection 09/01/1985 - "The use of SPLVs as a drug carrier has broad application to treatment of infections due to other organisms." 01/01/2015 - "Enhanced uptake of particulate drug carriers by macrophages could be beneficial in pathological conditions such as tuberculosis and HIV where infectious microorganisms utilize macrophages as a safe haven and a vehicle to further infections. " 03/01/2007 - "We observed that especially in alkaline medium a high release was found that was convenient for the vaginal infections seen in the alkaline pH. We concluded that W/O/W multiple emulsions were locally effective in vagina and they could be introduced as a new drug carrier system for vaginal delivery." 02/01/1989 - "We report the development of an antiamoebic drug carrier that may be effective against luminal infections. " 01/01/2015 - "Hydroxyapatite (HA) has been studied recently as a drug carrier in prevent implant infections due to its biocompatibility and osteoconductive properties, but most of these studies failed to control infection. "
3.	Brain Neoplasms (Brain Tumor) 04/01/2009 - "This study indicates the potential of CED with the polymeric micelle drug carrier system for the treatment of brain tumors." 04/01/2010 - "Macrophages and MG could potentially be used as nanoparticle drug carriers into malignant brain tumors." 04/01/2009 - "Convection-enhanced delivery (CED) with various drug carrier systems has recently emerged as a novel chemotherapeutic method to overcome the problems of current chemotherapies against brain tumors. " 12/01/1995 - "The authors conclude that the use of long-circulating liposomes as cytotoxic drug carriers in brain tumor results in enhanced drug exposure and improved therapeutic activity, with equal effectiveness against early small- and large-sized brain tumors." 07/01/2005 - "mAb 2C5 specifically recognizes brain tumor cells and can serve as a ligand to target drug carriers such as liposomes to brain tumor cells in vivo."
4.	Glioma (Gliomas) 10/01/2000 - "An improved understanding of the vascular microenvironment in gliomas will help in the future to optimize glioma imaging and delivery of vectors for gene therapy or encapsulated drug carriers in patients." 07/01/2015 - "Therefore, FA-BO-PAMAM is a promising nanodrug delivery system in employing PAMAM as a drug carrier and treatment for brain glioma." 10/01/2012 - "The present paper mainly reviews the structure and methods of synthesis, celluar cytotoxicity, achievements of gene and drug carriers research, advancement and prospect of PAMAM as a carrier in glioma therapy. " 01/01/2004 - "An improved understanding of the vascular microenvironment in gliomas will help in the future to optimize glioma imaging and to improve delivery of vectors for gene therapy or encapsulated drug carriers for pharmacotherapy in patients." 04/01/2013 - "These results show that nanocapsules functionalized with the NFL-TBS.40-63 peptide represent a powerful drug-carrier system for glioma targeted treatment."
5.	Cicatrix (Scar) 01/01/2014 - "In order to overcome the limitations of common local ophthalmic medications, we investigated the function of a self-assembled PECE hydrogel as an intracameral injection-implanted drug carrier to inhibit the formation of postoperative scarring. " 07/01/2010 - "In conclusion, three different sizes of 5-FU ethosomes were prepared successfully, the ethosomes of 65 nm in diameter with 5-FU can penetrate scar high efficiently, which has potential in application such as anti-scar drug carriers in scar therapy in near future." 03/15/2015 - "Developed novel adhesive silicone films were considered an effective treatment of scars and keloids and a potential drug carrier able to improve the effectiveness of therapy." 08/25/2011 - "Adhesive silicone films can be used as universal materials for medical use, particularly for effective treatment of scars and keloids or as drug carriers in transdermal therapy."

Related Drugs and Biologics

1.	Liposomes (Liposome)
2.	Micelles
3.	Lipoproteins (Lipoprotein)
4.	Antineoplastic Agents (Antineoplastics)
5.	Silicones
6.	Dendrimers (Dendrons)
7.	Doxorubicin (Adriamycin)
8.	polylactic acid-polyglycolic acid copolymer (PLGA)
9.	Carbon Monoxide
10.	Glycoproteins (Glycoprotein)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Microspheres (Microsphere)
3.	Injections
4.	Heterologous Transplantation (Xenotransplantation)
5.	Immunotherapy