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Doxycycline (Vibramycin)

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A synthetic TETRACYCLINE derivative with similar antimicrobial activity. Animal studies suggest that it may cause less tooth staining than other tetracyclines. It is used in some areas for the treatment of chloroquine-resistant falciparum malaria (MALARIA, FALCIPARUM).

Also Known As:

Vibramycin; BMY-28689; BU-3839T; CollaGenex Brand of Doxycycline; Doxycycline Calcium; Doxycycline Calcium Salt (1:2); Doxycycline Monohydrate; Doxycycline Monohydrochloride, 6-epimer; Doxycycline Monohydrochloride, Dihydrate; Doxycycline Phosphate (1:1); Doxycycline-Chinoin; Hydramycin; Oracea; Vibramycin Novum; Vibravenos; alpha-6-Deoxyoxytetracycline; BMY 28689; BMY28689; BU 3839T; BU3839T; Dihydrate Doxycycline Monohydrochloride; Doxycycline Chinoin; Doxycycline CollaGenex Brand; Doxycycline Monohydrochloride, 6 epimer; Monohydrochloride, Dihydrate Doxycycline; Novum, Vibramycin; alpha 6 Deoxyoxytetracycline; 2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, (4S-(4alpha,4aalpha,5alpha,5aalpha,6alpha,12aalpha))-

Networked: 3530 relevant articles (500 outcomes, 571 trials/studies)

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Drug Context: Research Results

Experts

1.	Raoult, Didier: 25 articles (06/2015 - 01/2003)
2.	Hoerauf, Achim: 23 articles (08/2015 - 04/2003)
3.	Golub, Lorne M: 19 articles (10/2013 - 03/2002)
4.	Sorsa, Timo: 16 articles (09/2015 - 01/2004)
5.	Mand, Sabine: 14 articles (08/2015 - 04/2003)
6.	Del Rosso, James Q: 13 articles (05/2015 - 07/2005)
7.	Tanus-Santos, Jose E: 12 articles (01/2014 - 09/2005)
8.	Specht, Sabine: 11 articles (08/2015 - 09/2006)
9.	Gerlach, Raquel F: 11 articles (07/2015 - 09/2005)
10.	Lee, Hsi-Ming: 11 articles (07/2013 - 03/2004)

Related Diseases

1.	Infection 08/01/2011 - "Our findings show that doxycycline 100 mg twice daily for seven days is highly effective treatment for asymptomatic rectal CT infection, achieving clearance of CT in 98.8% (163/165; 95% CI 95.4-99.9%) of cases. " 11/01/2011 - "The effect of doxycycline on heartworm microfilariae, optimal testing methodologies, and verification of effective clearance of microfilariae after adulticide treatment and microfilaricidal therapy so that dogs do not remain a potential source of infection for other dogs are all covered." 12/01/2007 - "The infection resolved completely after successful treatment with doxycycline for 6 months. " 10/01/1999 - "The findings show that doxycycline intervention of infection, although very effective in eradicating chlamydiae from genital tissue and preventing upper genital tract disease, significantly inhibits the development of protective immunity. " 12/01/2009 - "muris-primed mice treated with doxycycline showed significantly greater susceptibility to challenge infection with IOE compared to untreated mice persistently infected with E. "
2.	Rosacea (Acne Rosacea) 01/01/2010 - "After 16 weeks' therapy, anti-inflammatory dose doxycycline 40 mg was significantly more effective in improving rosacea than placebo, providing a greater reduction in the total inflammatory lesion count (primary endpoint) than placebo. " 11/01/2011 - "Recently, a big randomized double-blind dose-response and comparative study revealed that an optimized dosage of 0,3 mg/kg was superior to other dosages and non-inferior to doxycycline as gold standard of systemic rosacea treatment and proved effective and safe in papulopustular and phymatous subtypes. " 01/01/2010 - "Recently, subantimicrobial-dose doxycycline was demonstrated to be an effective treatment for rosacea, due to its inherent anti-inflammatory properties. " 07/01/2007 - "Is low-dose doxycycline effective for rosacea?" 05/01/2007 - "Once-daily anti-inflammatory dose doxycycline appears to be effective and safe for the treatment of rosacea."
3.	Brucellosis (Malta Fever) 02/01/2011 - "The nanoparticulate formulation of lipomer doxycycline hydrochloride (lipomer DH) has been synthesized for the treatment of Brucellosis to increase efficacy of the drug. " 05/21/1994 - "[Meta-analysis of the efficacy of the combination of +rifampicin and doxycycline in the treatment of human brucellosis]." 10/01/2013 - "Randomized controlled trials demonstrate that optimal treatment for human brucellosis consists of doxycycline and an aminoglycoside. " 01/01/2012 - "Although the preferred treatment in uncomplicated human brucellosis is doxycycline-aminoglycoside combination, other treatments based on oral regimens or monotherapy should not be rejected until they are better studied. " 12/01/2005 - "Four patients with brucellosis developed yellow-brown discolouration of teeth following a 30-45 day course of doxycycline therapy during summer at a dose of 200mg/day. "
4.	Acne Vulgaris 12/01/2008 - "Subantimicrobial-dose doxycycline administered twice daily for 3 months in patients with moderate inflammatory acne results in significant reduction in the number of total inflammatory lesions. " 12/01/2008 - "Subantimicrobial-dose doxycycline is an effective treatment for patients with moderate acne vulgaris." 08/01/2003 - "Low-dose doxycycline moderately effective for acne." 12/01/2008 - "The purpose of this study was to compare the efficacy of doxycycline at antimicrobial and subantimicrobial doses for the treatment of acne. " 02/01/2010 - "These findings provide evidence on the efficacy of combining A/BPO and the oral antibiotic doxycycline in the treatment of severe acne vulgaris."
5.	Urethritis 03/01/2002 - "The regimen of 100 mg. doxycycline orally twice daily for 7 days, which is recommended for chlamydial nongonococcal urethritis, seems to be effective for M. " 01/01/2015 - "The efficacy of doxycycline, used extensively to treat non-gonococcal urethritis in the past, is relatively poor for M. " 01/01/1986 - "The efficacy of doxycycline in the treatment of chlamydial urethritis was evaluated in 106 patients. " 01/01/1986 - "[Clinical studies on doxycycline in the treatment of nongonococcal urethritis by Chlamydia trachomatis]." 11/01/1985 - "[Clinical studies on doxycycline in male nongonococcal urethritis]."

Related Drugs and Biologics

1.	Azithromycin (Zithromax)
2.	Rifampin (Rifampicin)
3.	Tetracycline (Achromycin)
4.	Ciprofloxacin (Cipro)
5.	Minocycline (Cyclops)
6.	Ceftriaxone (Ceftriaxon)
7.	Anti-Bacterial Agents (Antibiotics)
8.	Amoxicillin (Wymox)
9.	Trimethoprim-Sulfamethoxazole Combination (Co-Trimoxazole)
10.	Streptomycin (Streptomycin Sulfate)

Related Therapies and Procedures

1.	Root Planing
2.	Sclerotherapy
3.	Pleurodesis
4.	Chemoprevention
5.	Drug Therapy (Chemotherapy)