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Dopamine beta-Hydroxylase

Subscribe to New Research on Dopamine beta-Hydroxylase

Also Known As:

Dopamine beta-Monooxygenase; Dopamine beta Hydroxylase; Dopamine beta Monooxygenase; beta-Hydroxylase, Dopamine; beta-Monooxygenase, Dopamine; 3,4-Dihydroxyphenethylamine, ascorbate:oxygen oxidoreductase (beta-hydroxylating)

Networked: 545 relevant articles (4 outcomes, 46 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Enzymes and Coenzymes
- Enzymes: 34502
  - Oxidoreductases: 9264
    - Oxygenases: 89
      - Mixed Function Oxygenases: 449
        Dopamine beta-Hydroxylase: 545
        Dopamine beta hydroxylase deficiency: 33

Experts

1.	Weinshenker, David: 9 articles (03/2010 - 01/2002)
2.	Cubells, Joseph F: 5 articles (12/2007 - 02/2003)
3.	Yang, Li: 3 articles (10/2015 - 06/2004)
4.	Kosten, Thomas R: 3 articles (07/2013 - 11/2003)
5.	Griffiths, L R: 3 articles (07/2009 - 09/2000)
6.	Quinlan, S: 3 articles (07/2009 - 09/2000)
7.	Lea, R A: 3 articles (07/2009 - 09/2000)
8.	Thomas, Steven A: 3 articles (05/2007 - 08/2003)
9.	Kovacic, Srecko: 3 articles (12/2006 - 04/2003)
10.	Bunc, Gorazd: 3 articles (12/2006 - 04/2003)

Related Diseases

1.	Hypertension (High Blood Pressure) 05/20/1979 - "[Study on Dopamine-beta-hydroxylase activity in serum in patients with essential hypertension at rest and during exercise (author's transl)]." 02/08/1974 - "Plasma dopamine beta-hydroxylase: a possible aid in the study and evaluation of hypertension." 02/01/1994 - "4. Cerebrospinal fluid dopamine beta-hydroxylase was not changed in essential hypertension. " 09/01/1989 - "A defect of beta-hydroxylation, partly attributable to deficient dopamine beta-hydroxylase activity, may thus precede hypertension and contribute to the hyperdopaminergic state found in SHR." 12/01/1986 - "EO-induced hypertension was associated with significant increase in dopamine-beta-hydroxylase activity of adrenal glands. "
2.	Cocaine-Related Disorders (Cocaine Addiction) 01/01/2008 - "Dopamine-beta hydroxylase polymorphism and cocaine addiction." 08/01/2009 - "Here, we synthesize clinical and animal data that point to dopamine beta-hydroxylase inhibition as a mechanism underlying the efficacy of disulfiram in the treatment of cocaine dependence." 12/01/2010 - "Several studies have looked for a link between cocaine addiction and the genes of the dopaminergic system: the genes DRD2, COMT, SLC6A3 (coding for the dopamine transporter DAT) and DBH (coding for the dopamine beta hydroxylase) but unfortunately very few well established results. " 03/01/2010 - "Although disulfiram's mechanism of action in alcohol dependence was long thought to be its effects as a psychological deterrent, more recent studies have uncovered potential anti-craving effects as well as direct effects of disulfiram on cocaine abuse, highlighting a few of the many potential and unique benefits disulfiram may have through its inhibition of dopamine beta-hydroxylase. " 07/01/2007 - "Of particular interest is disulfiram, an inhibitor of the NE biosynthetic enzyme dopamine beta-hydroxylase, which has demonstrated promising efficacy in the treatment of cocaine dependence in preliminary clinical trials. "
3.	Chronic Kidney Failure (Chronic Renal Failure) 05/01/1980 - "A fall in dopamine-beta-hydroxylase activity in the plasma and a reduction in the lability of blood pressure in these three patients suggest that improved blood pressure control is the result of improvement in the defective baroreceptor reflex noted to be present in patients mith chronic renal failure and hypertension." 10/01/1975 - "Serum dopamine-beta-hydroxylase activity in essential hypertension and in chronic renal failure with hypertension." 07/16/1979 - "Plasma catecholamines and dopamine-beta-hydroxylase activity in chronic renal failure." 07/01/1979 - "To evaluate the activity of the sympathetic nervous system in chronic renal failure, plasma norepinephrine (NE) and dopamine-beta-hydroxylase (DBH) activity were measured by a radioenzymatic assay and a photometric assay respectively. " 07/01/1979 - "Plasma norepinephrine and dopamine-beta-hydroxylase activity in chronic renal failure."
4.	Pure Autonomic Failure 07/15/2003 - "Variations in the dopamine beta-hydroxylase gene are not associated with the autonomic disorders, pure autonomic failure, or multiple system atrophy." 06/01/1993 - "Patients in whom a deficiency of the enzyme dopamine-beta-hydroxylase is present from birth have many features suggestive of the Bradbury-Eggleston syndrome but manifest normal sweating and biochemically have an elevated plasma and urinary dopamine level. " 07/15/2003 - "Recent findings of an association between human NE deficiency and variants at the dopamine beta-hydroxylase (DBH) gene [Kim et al., 2002] prompted us to investigate these markers in patients with autonomic disorders; 38 with orthostatic intolerance (OI), 26 with pure autonomic failure (PAF), and 39 with multiple system atrophy (MSA). " 08/01/1991 - "The effect of a balanced liquid meal on supine and postural blood pressure (BP) responses was investigated in three groups of patients with chronic autonomic failure; 10 with associated neurological impairment (multiple system atrophy (MSA), Shy-Drager syndrome) and seven without (of which five had pure autonomic failure (PAF); and two had a deficiency of the enzyme dopamine beta hydroxylase, DBH-deficiency). " 01/01/2006 - "DOPS improved orthostatic hypotension in patients with familial amyloid polyneuropathy, congenital deficiency of dopamine beta hydroxylase, pure autonomic failure and multiple system atrophy. "
5.	Orthostatic Hypotension (Postural Hypotension) 05/01/1978 - "To determine whether orthostatic hypotension in patients with cervical spinal cord lesions is the result of impaired sympathetic nerve response and/or impaired renin release, serum dopamine-beta-hydroxylase (DbetaH) activity and plasma renin activity (PRA) were examined during passive tilting in 6 quadriplegic patients and in 6 able-bodied control subjects. " 05/01/1978 - "Plasma renin and serum dopamine-beta-hydroxylase during orthostatic hypotension in quadriplegic man." 01/01/2006 - "DOPS improved orthostatic hypotension in patients with familial amyloid polyneuropathy, congenital deficiency of dopamine beta hydroxylase, pure autonomic failure and multiple system atrophy. " 04/01/1995 - "The effect of supine exercise on blood pressure (BP), measured while recumbent and after head-up postural change, was investigated in three groups with marked postural hypotension due to chronic autonomic failure: 15 with associated neurological impairment (Shy-Drager syndrome, SDS, multiple system atrophy); 15 with pure autonomic failure (PAF) and two with a deficiency of the enzyme dopamine beta hydroxylase (DBH deficiency). " 01/01/2003 - "Dopamine beta hydroxylase enzyme deficiency is a congenital disease characterised by the failure to convert dopamine into noradrenaline which results in orthostatic hypotension. "

Related Drugs and Biologics

1.	Norepinephrine (Noradrenaline)
2.	Catecholamines
3.	Epinephrine (Adrenaline)
4.	Disulfiram (Antabuse)
5.	Catechol O-Methyltransferase (Methyltransferase, Catechol)
6.	Vanilmandelic Acid (Vanillylmandelic Acid)
7.	Tyrosine 3-Monooxygenase (Tyrosine Hydroxylase)
8.	Monoamine Oxidase (MAO)
9.	Dopamine Plasma Membrane Transport Proteins (Dopamine Transporter)
10.	Neurotransmitter Agents (Neurotransmitter)

Related Therapies and Procedures

1.	Sympathectomy (Sympathectomies)
2.	Renal Dialysis (Hemodialysis)
3.	Ligation
4.	Kidney Transplantation
5.	Axotomy