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Domperidone (Domperidon)

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A specific blocker of dopamine receptors. It speeds gastrointestinal peristalsis, causes prolactin release, and is used as antiemetic and tool in the study of dopaminergic mechanisms.

Also Known As:

Domperidon; Aliud Brand of Domperidone Maleate; Apo-Domperidone; Apotex Brand of Domperidone Maleate; Domidon; Domperidon AL; Domperidon Hexal; Domperidon Stada; Domperidon-TEVA; Domperidona Gamir; Domperidone Maleate; Domperidone Maleate (1:1); Domperidone Monohydrochloride; Gastrocure; Gry Brand of Domperidone Maleate; Hexal Brand of Domperidone Maleate; Janssen Brand of Domperidone; Motilium; Nauzelin; Novo-Domperidone; Novopharm Brand of Domperidone Maleate; Nu-Domperidone; Nu-Pharm Brand of Domperidone Maleate; PMS-Domperidone; Pharmascience Brand of Domperidone Maleate; Pierre Fabre Brand of Domperidone; Péridys; R-33,812; R-33812; Ratiopharm Brand of Domperidone Maleate; Rottapharm Brand of Domperidone; Stadapharm Brand of Domperidone Maleate; Taxandria Brand of Domperidone Maleate; Teva Brand of Domperidone Maleate; ratio-Domperidone; Apo Domperidone; Domperidon TEVA; Gamir, Domperidona; Hexal, Domperidon; Maleate, Domperidone; Monohydrochloride, Domperidone; Novo Domperidone; Nu Domperidone; Nu Pharm Brand of Domperidone Maleate; PMS Domperidone; R33,812; R33812; Stada, Domperidon; ratio Domperidone; 2H-Benzimidazol-2-one, 5-chloro-1-(1-(3-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)propyl)-4-piperidinyl)-1,3-dihydro-

Networked: 592 relevant articles (68 outcomes, 91 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Parkman, Henry P: 5 articles (09/2014 - 01/2011)
2.	Rudd, John A: 4 articles (12/2008 - 12/2003)
3.	Joseph, Vincent: 3 articles (08/2011 - 03/2002)
4.	Soliz, Jorge: 3 articles (06/2009 - 03/2002)
5.	Kan, Kelvin K W: 3 articles (12/2008 - 12/2003)
6.	Hovey, R C: 2 articles (01/2016 - 03/2013)
7.	Trott, J F: 2 articles (01/2016 - 03/2013)
8.	Ochoa-Amaya, Julieta E: 2 articles (12/2015 - 01/2011)
9.	Fife, Daniel: 2 articles (12/2015 - 09/2010)
10.	Felicio, Luciano F: 2 articles (12/2015 - 01/2011)

Related Diseases

1.	Vomiting 09/01/1980 - "In this study neither vomiting nor the efficacy of domperidone were found to be related to the type of surgery, the type of anaesthetic or the physical status (ASA I-III) of the patient (p greater than 0.05)." 11/01/1978 - "A cross-over double-blind trial was conducted in 14 patients (20 double-blind treatment courses) comparing domperidone and placebo in the treatment of vomiting due to intensive cytostatic treatment. " 11/01/1978 - "In the double-blind trial, vomiting recurred significantly later in domperidone than in placebo-treated patients. " 01/01/1978 - "The effect of domperidone on vomiting due to cytostatic treatment was studied during a double-blind trial involving 41 patients. " 02/01/2013 - "Case series: paradoxical action of domperidone leads to increased vomiting."
2.	Nausea 03/01/2011 - "Therefore, domperidone probably ameliorates nausea through other mechanisms." 11/01/2014 - "Domperidone is commonly used to treat nausea and gastrointestinal disorders. " 02/01/2009 - "A reduction in the dopaminergic side-effect nausea was seen with domperidone comedication. " 07/01/2001 - "Five patients needed domperidone for treatment of concomitant nausea. " 05/22/2001 - "Side effects, in particular nausea, were common but were well controlled by domperidone in most patients."
3.	Dyspepsia (Indigestion) 04/01/2011 - "Both the medical device and domperidone significantly improved gastrointestinal symptoms and quality of life in subjects with functional dyspepsia, not showing significant difference in efficacy." 12/01/1988 - "Although domperidone therapy had no significant effect on motility, it appears to be an effective drug for the treatment of the symptoms of nonulcer dyspepsia." 01/01/2015 - "Clinical symptom scores combined with real-time ultrasonography is effective in evaluating the therapeutic effect of domperidone in patients with functional dyspepsia. " 04/01/2011 - "The aim of the study was to evaluate the efficacy of a new medical device in respect to domperidone in patients with functional dyspepsia. " 04/01/2011 - "In a cross-over, randomized trial, 36 patients with functional dyspepsia ingested two daily doses of a medical device (Digerfast) or domperidone (Peridon) for 21 days. "
4.	Gastroesophageal Reflux (GERD) 05/01/1992 - "We conclude that domperidone is tolerated by most infants and children with gastroesophageal reflux; however, 4 weeks of therapy was only minimally effective in producing objective improvement of gastroesophageal reflux and did not result in symptomatic improvement. " 05/01/1992 - "Further studies of longer duration are needed to resolve the question raised by this study: that domperidone may be beneficial for patients with gastroesophageal reflux when given for more than four weeks." 05/01/1992 - "Therapy with domperidone for 4 weeks was effective only in reducing the total number of reflux episodes in the two-hour postprandial period (p less than 0.01); however, it did not result in symptomatic improvement or significant improvement in other measures of gastroesophageal reflux or gastric emptying. " 01/01/1979 - "It was found that domperidone increased LOSP significantly but was less effective in patients with symptomatic gastro-oesophageal reflux than in normal volunteers. " 01/01/1979 - "At the end of the double-blind phase all indices but one (bitter regurgitation) as well as the gastro-oesophageal reflux cluster had significantly improved on domperidone treatment while none had done so on placebo. "
5.	Gastroparesis 05/01/1998 - "The results of this study suggest that domperidone 20 mg QID provides significant improvement in the upper gastrointestinal symptoms of diabetic gastroparesis and is well tolerated in patients with this condition." 07/01/2008 - "Overall, our assessment is that there is level 3 evidence for the efficacy of domperidone in diabetic gastroparesis, leading to a grade C recommendation for its use in this condition. " 07/01/2008 - "Our objective was to systematically analyze studies of the efficacy of domperidone in diabetic gastroparesis, with a focus on their methodologic and scientific merit. " 07/01/2008 - "A systematic review of the efficacy of domperidone for the treatment of diabetic gastroparesis." 04/01/2014 - "The aim of this preliminary study was to compare the effectiveness of domperidone and acupuncture for the management of diabetic gastroparesis. "

Related Drugs and Biologics

1.	Metoclopramide (Reglan)
2.	Cisapride (Propulsid)
3.	Antiemetics
4.	Ondansetron (Zofran)
5.	Cimetidine (Biomet)
6.	levosulpiride
7.	Ranitidine (Zantac)
8.	rabeprazole (Aciphex)
9.	Apomorphine
10.	Dopamine Antagonists

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Oral Administration
3.	Gynecologic Surgical Procedures (Gynecologic Surgery)
4.	Fluid Therapy (Oral Rehydration Therapy)
5.	Acupuncture Points (Acupuncture Point)