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Dobutamine

A catecholamine derivative with specificity for BETA-1 ADRENERGIC RECEPTORS. It is commonly used as a cardiotonic agent after CARDIAC SURGERY and during DOBUTAMINE STRESS ECHOCARDIOGRAPHY.

Also Known As:

Boehringer Ingelheim Brand of Dobutamine Hydrochloride; Dobucor; Dobuject; Dobutamin Fresenius; Dobutamin Hexal; Dobutamin Solvay; Dobutamin-ratiopharm; Dobutamina Inibsa; Dobutamina Rovi; Dobutamine (+)-Isomer; Dobutamine Hydrobromide; Dobutamine Hydrochloride; Dobutamine Lactobionate; Dobutamine Phosphate (1:1) Salt, (-)-Isomer; Dobutamine Tartrate; Dobutamine Tartrate (1:1), (R-(R*,R*))-Isomer; Dobutamine Tartrate (1:1), (S-(R*,R*))-Isomer; Dobutamine, (-)-Isomer; Dobutamine, Phosphate (1:1) Salt (+)-Isomer; Dobutrex; Eli Lilly Brand of Dobutamine Hydrochloride; Fresenius Brand of Dobutamine Hydrochloride; Hexal Brand of Dobutamine Hydrochloride; Inibsa Brand of Dobutamine Hydrochloride; Irisfarma Brand of Dobutamine Hydrochloride; Juste Brand of Dobutamine Hydrochloride; Kendrick Brand of Dobutamine Hydrochloride; Lilly 81929; Lilly Brand of Dobutamine Hydrochloride; Oxiken; Pisa Brand of Dobutamine Hydrochloride; Posiject; Rovi Brand of Dobutamine Hydrochloride; Solvay Brand of Dobutamine Hydrochloride; ratiopharm Brand of Dobutamine Hydrochloride; Dobutamin ratiopharm; Hydrobromide, Dobutamine; Hydrochloride, Dobutamine; Lactobionate, Dobutamine; Tartrate, Dobutamine; 1,2-Benzenediol, 4-(2-((3-(4-hydroxyphenyl)-1-methylpropyl)amino)ethyl)-, (+-)-

Networked: 3449 relevant articles (249 outcomes, 645 trials/studies)

Relationship Network

Drug Context: Research Results

Organic Chemicals: 58
- Amines: 1422
  - Catecholamines: 6143
    - Dobutamine: 3449
      - 4-(2-((3-(3-benzenecarboxamide)-1-methylpropyl)amino)ethyl)-1,2-benzenediol: 2
      - 3-O-methyldobutamine
  - Ethylamines: 5
    - Phenethylamines: 14
      - Dobutamine: 3449
        4-(2-((3-(3-benzenecarboxamide)-1-methylpropyl)amino)ethyl)-1,2-benzenediol: 2
        3-O-methyldobutamine

Experts

1.	Bax, Jeroen J: 58 articles (12/2015 - 06/2002)
2.	Elhendy, Abdou: 51 articles (12/2011 - 06/2002)
3.	Poldermans, Don: 50 articles (12/2011 - 06/2002)
4.	Schinkel, Arend F L: 37 articles (10/2015 - 06/2002)
5.	van Domburg, Ron T: 31 articles (10/2015 - 06/2002)
6.	Bax, J J: 26 articles (05/2007 - 01/2000)
7.	Marwick, Thomas H: 24 articles (06/2014 - 06/2002)
8.	Poldermans, D: 20 articles (05/2007 - 06/2000)
9.	Picano, Eugenio: 19 articles (02/2013 - 02/2003)
10.	Biagini, Elena: 19 articles (12/2011 - 03/2004)

Related Diseases

1.	Heart Failure 11/11/2003 - "Myocardial contractile reserve by dobutamine stress echocardiography predicts improvement in ejection fraction with beta-blockade in patients with heart failure: the Beta-Blocker Evaluation of Survival Trial (BEST)." 01/01/2003 - "Significant benefits were also seen for mortality (versus placebo or dobutamine) and for the combined risk of worsening heart failure or death (versus dobutamine). " 12/01/1986 - "The intermittent use of dobutamine may be beneficial in the chronic treatment of congestive heart failure in patients who fail to respond to conventional therapy." 12/01/1986 - "Studies utilizing dobutamine doses ranging from 1.5 to 15 micrograms/kg/min for 4-48 h/wk have shown sustained clinical and hemodynamic improvement in patients suffering from congestive heart failure. " 01/05/1999 - "Sustained improvement in flow-mediated vasodilation after short-term administration of dobutamine in patients with severe congestive heart failure."
2.	Myocardial Infarction 01/01/2000 - "We conclude that the restored positive T waves in Q-wave myocardial infarction indicate a significantly greater amount of viable myocardium than the negative T waves, showing better regional wall motion improvement with low-dose dobutamine stress." 12/01/1991 - "To assess the effects of coronary revascularization on viable but noncontractile myocardium, we examined 21 patients with a documented anterior acute myocardial infarction who had a significant improvement in wall motion abnormality evaluated by two-dimensional echocardiography in the infarct-related artery in response to low-dose dobutamine infusion. " 09/01/2000 - "The overall positive predictive value of improved regional wall motion after CABG did not vary with left ventricular ejection fraction, a history of myocardial infarction, or beta blocker use, and it varied little with diabetic status (range, 0.86-0.96) if regional wall motion improved with low-dose dobutamine before CABG. " 12/01/1991 - "We conclude that: (1) low-dose dobutamine infusion may identify viable but noncontractile myocardium in patients with acute myocardial infarction and (2) in these patients revascularization causes a greater improvement in left ventricular function over time when compared with a nonrevascularized group." 12/01/1997 - "Previous studies have shown that low dose dobutamine echocardiography was accurate for detecting reversible dysfunction after acute myocardial infarction (MI) but did not determine whether accuracy was improved by peak dose findings or influenced by the test interval or clinical or angiographic factors. "
3.	Coronary Artery Disease (Coronary Atherosclerosis) 12/01/2000 - "Prediction of improvement in global left ventricular function in patients with chronic coronary artery disease and impaired left ventricular function: rest thallium-201 SPET versus low-dose dobutamine echocardiography." 02/01/1996 - "Thus dobutamine echocardiography is superior to exercise electrocardiography for diagnosis of coronary artery disease in hypertensive patients." 04/01/2000 - "Dobutamine stress echocardiography is considered a relatively well-tolerated diagnostic modality, effective in the management of patients with known or suspected coronary artery disease. " 09/16/2008 - "Dobutamine stress echocardiography (DSE) has been shown to be a very useful non-invasive technique for the detection of coronary artery disease. " 01/01/2015 - "The aim of this study was to determine whether NLR improved the positive predictive value (PPV) of dobutamine stress echocardiography (DSE) in patients with stable coronary artery disease (CAD). "
4.	Ischemia 01/01/2010 - "Alternatively, a low-high dose dobutamine protocol can be used in which a biphasic response characterized by improved contractile function during the low-dose infusion followed by a deterioration in contractility due to stress induced ischemia during the high dose dobutamine infusion (dobutamine dose up to 40 ug/kg/min) represents viable tissue. " 01/01/2010 - "Alternatively, a low-high dose dobutamine protocol can be used in which a biphasic response characterized by improved contractile function during the low-dose infusion followed by a deterioration in contractility due to stress induced ischemia during the high dose dobutamine infusion (dobutamine dose up to 40 ug/kg/min) represents viable tissue. " 04/01/2008 - "(3) Calibrated CI and WT significantly improved in Group I rabbits while these parameters remained unchanged in Group II rabbits after increasing doses of dobutamine post ischemia. " 11/01/2005 - "We observed improvement in resting wall motion score only in the segments with hibernation in baseline DSE (2.3 +/- 0.5 to 2.0 +/- 0.6, P = .03) and improvement in high-dose dobutamine wall motion score, only in segments showing significant ischemia at baseline DSE (2.5 +/- 0.5 to 2.0 +/- 0.6, P = .001). " 01/01/2004 - "On the basis of the dobutamine stress echocardiography-induced ischemia, which exacerbated the degree of MR, a revascularization operation sparing the mitral valve was performed, resulting in significant improvement of the MR. "
5.	Left Ventricular Dysfunction 11/01/1994 - "Improvement in wall motion during dobutamine echocardiography and normal or mildly decreased uptake on thallium-201 scanning are strong predictors of reversible left ventricular dysfunction. " 12/01/2001 - "This study suggests that GI-Tl SPECT is superior to reinjection imaging and dobutamine echocardiography in predicting functional recovery after ischemic left ventricular dysfunction." 10/01/2007 - "Viability at dobutamine stress echocardiography independently predicts improved outcome following revascularization in non-diabetics as well as diabetic patients with ischaemic left ventricular dysfunction." 05/01/2005 - "Patients with severe left ventricular dysfunction and myocardial viability by dobutamine stress echocardiography (DSE) or F18-fluorodeoxyglucose-single-photon emission computed tomography (FDG-SPECT), experience improved survival after coronary revascularization. " 06/01/2000 - "Nine patients had left ventricular dysfunction unchanged compared with the initial measurement without viability in the territory of the left anterior descending artery with low dose dobutamine (group 1); thirty-two patients had improved or normal left ventricular ejection fraction with myocardial viability (group 2). "

Related Drugs and Biologics

1.	Dopamine (Intropin)
2.	simendan (Levosimendan)
3.	Amrinone (Amrinon)
4.	Norepinephrine (Noradrenaline)
5.	Nitroprusside (Sodium Nitroprusside)
6.	Epinephrine (Adrenaline)
7.	Milrinone (Primacor)
8.	Dipyridamole (Persantine)
9.	Enoximone
10.	Brain Natriuretic Peptide (Natrecor)

Related Therapies and Procedures

1.	Angioplasty (Angioplasty, Transluminal)
2.	Resuscitation
3.	Intravenous Infusions
4.	Thrombolytic Therapy
5.	Cardiopulmonary Bypass (Heart-Lung Bypass)