DNA-Directed DNA Polymerase (Polymerases, DNA)

DNA-dependent DNA polymerases found in bacteria, animal and plant cells. During the replication process, these enzymes catalyze the addition of deoxyribonucleotide residues to the end of a DNA strand in the presence of DNA as template-primer. They also possess exonuclease activity and therefore function in DNA repair. EC
Also Known As:
Polymerases, DNA; DNA Polymerase N3; DNA Dependent DNA Polymerases; DNA Directed DNA Polymerase; DNA Polymerase, DNA-Directed; DNA Polymerases, DNA-Dependent; Polymerase N3, DNA; Polymerase, DNA-Directed DNA; Polymerases, DNA-Dependent DNA; DNA Polymerases; DNA-Dependent DNA Polymerases; Deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed)
Networked: 269 relevant articles (4 outcomes, 6 trials/studies)

Relationship Network

Bio-Agent Context: Research Results


1. Mizushina, Yoshiyuki: 10 articles (04/2014 - 10/2003)
2. Yoshida, Hiromi: 7 articles (02/2012 - 10/2003)
3. Sakaguchi, Kengo: 5 articles (05/2005 - 10/2003)
4. Shcherbakova, Polina V: 4 articles (05/2015 - 01/2006)
5. Kuramochi, Kouji: 4 articles (01/2013 - 05/2004)
6. Sugawara, Fumio: 4 articles (02/2012 - 10/2003)
7. Kuriyama, Isoko: 4 articles (02/2012 - 12/2003)
8. Takemura, Masaharu: 4 articles (05/2005 - 06/2002)
9. Pavlov, Youri I: 3 articles (12/2014 - 08/2003)
10. Eckert, Kristin A: 3 articles (07/2014 - 06/2010)

Related Diseases

1. Neoplasms (Cancer)
2. Infection
3. Sarcoma (Soft Tissue Sarcoma)
4. Drug Toxicity (Drug Safety)
5. Fanconi Anemia (Fanconi's Anemia)
12/01/2012 - "The potential role of Fanconi anemia pathway in the regulation of REV1 and PolĪ¶-dependent TLS and the involvement of additional polymerases, including DNA polymerases kappa, nu, and theta, in the repair of ICLs is also discussed in this review."
01/01/2011 - "These variants were chosen to represent five DNA repair pathways including base excision repair, nucleotide excision repair, double-strand break repair (homologous recombination and non-homologous end-joining), direct reversal repair, and mismatch repair, along with candidate DNA polymerases, Fanconi Anemia complementation groups, and other genes relevant to DNA damage recognition and response. "
06/01/2009 - "In this nested case-control study of 239 prospectively ascertained premenopausal breast cancer cases and 477 matched controls within the Nurses' Health Study II, we evaluated 1,463 genetic variants in 60 candidate genes across five DNA repair pathways, along with DNA polymerases, Fanconi Anemia complementation groups, and other related genes. "
06/01/1977 - "The activities of DNA polymerases alpha, beta, and gamma were determined in control and repair-deficient human fibroblasts (xeroderma pigmentosum complementation groups A, C, and D; Fanconi's Anemia; and Bloom's syndrome). "
06/01/1978 - "Fibroblasts derived from patients with diseases affecting DNA repair processes, such as Xeroderma Pigmentosum (classical and variant), Fanconi's anemia, Bloom's syndrome, Ataxia Telangiectasica, Progeria and Werner's syndrome, were assayed for the three DNA polymerases. "

Related Drugs and Biologics

1. DNA (Deoxyribonucleic Acid)
2. DNA-Directed RNA Polymerases (RNA Polymerase)
3. Ganciclovir (Cytovene)
4. Immune Sera (Antisera)
5. Proteins (Proteins, Gene)
6. Proliferating Cell Nuclear Antigen (PCNA)
7. RNA-Directed DNA Polymerase (Reverse Transcriptase)
8. DNA Nucleotidylexotransferase (Terminal Deoxynucleotidyl Transferase)
9. Suramin (Suramin Sodium)
10. Mitoxantrone (Novantrone)

Related Therapies and Procedures

1. Aftercare (After-Treatment)
2. Drug Therapy (Chemotherapy)
3. Chemoprevention
4. Transplantation (Transplant Recipients)
5. Radiotherapy