DNA Polymerase III (Pol III)

A DNA-dependent DNA polymerase characterized in E. coli and other lower organisms but may be present in higher organisms. Use also for a more complex form of DNA polymerase III designated as DNA polymerase III* or pol III* which is 15 times more active biologically than DNA polymerase I in the synthesis of DNA. This polymerase has both 3'-5' and 5'-3' exonuclease activities, is inhibited by sulfhydryl reagents, and has the same template-primer dependence as pol II. EC 2.7.7.7.

Also Known As:

Networked: 127 relevant articles (2 outcomes, 7 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	White, Robert J: 10 articles (02/2012 - 05/2002)
2.	Zhong, Shuping: 7 articles (02/2015 - 08/2009)
3.	Levy, Daniel: 5 articles (02/2015 - 01/2013)
4.	Zhong, Qian: 5 articles (02/2015 - 01/2013)
5.	Johnson, Deborah L: 5 articles (06/2013 - 05/2007)
6.	Shi, Ganggang: 4 articles (02/2015 - 08/2013)
7.	Kenneth, Niall S: 4 articles (02/2012 - 05/2003)
8.	Bernard, Geneviève: 3 articles (04/2015 - 11/2011)
9.	Vanderver, Adeline: 3 articles (04/2015 - 11/2011)
10.	Zhang, Yanmei: 3 articles (02/2015 - 08/2013)

Related Diseases

1.	Infection 08/01/2003 - "Overall our results demonstrate that the lentiviral-based vectors can efficiently deliver single constructs as well as combinations of Pol III therapeutic expression units into primary hematopoietic cells for anti-HIV gene therapy and hold promise for stem or T-cell-based gene therapy for HIV-1 infection." 08/01/2003 - "Inhibition of HIV-1 infection by lentiviral vectors expressing Pol III-promoted anti-HIV RNAs." 08/01/1995 - "The number of Alu transcripts that accumulate in HeLa and other human cells is normally very low; however, infection with adenovirus type 5 increases the expression of Alu elements dramatically, indicating that the potential for polymerase III (pol III)-dependent Alu transcription in vivo is far greater than generally observed (B. " 01/01/1990 - "subtilis DNA polymerase III. IG 1 phages originated either by induction or infection multiply, abundantly, in the presence of that azopyrimidine, in spite of the drastic decline of cell viability. " 09/01/2003 - "In contrast to human rhinovirus-16 infection, rRNA synthesis by pol-I and pol-III were not turned off by EMCV, although the cellular concentration of rRNA decreased during infection, relative to control samples. "
2.	Anodontia 04/01/2015 - "Magnetic resonance (MR) imaging (MRI) has dramatically improved and systematized the diagnosis of LDs and gLEs, and in combination with specific clinical features, such as Addison's disease in Adrenoleukodystrophy or hypodontia in Pol-III related or 4H leukodystrophy, can often resolve a case with a minimum of testing. "
3.	Adrenoleukodystrophy (Adrenoleukodystrophy, X-Linked) 04/01/2015 - "Magnetic resonance (MR) imaging (MRI) has dramatically improved and systematized the diagnosis of LDs and gLEs, and in combination with specific clinical features, such as Addison's disease in Adrenoleukodystrophy or hypodontia in Pol-III related or 4H leukodystrophy, can often resolve a case with a minimum of testing. "
4.	Addison Disease (Addison's Disease) 04/01/2015 - "Magnetic resonance (MR) imaging (MRI) has dramatically improved and systematized the diagnosis of LDs and gLEs, and in combination with specific clinical features, such as Addison's disease in Adrenoleukodystrophy or hypodontia in Pol-III related or 4H leukodystrophy, can often resolve a case with a minimum of testing. "
5.	Neoplasms (Cancer) 02/01/2015 - "Studies revealed that tumor suppressors, pRb, p53, PTEN and Maf1 repress the transcription of Pol III genes. " 02/01/2015 - "We have reported that alcohol intake increases Pol III gene transcription to promote cell transformation and tumor formation in vitro and in vivo. " 11/01/2013 - "Interestingly, DEN-induced Pol III gene transcription and H3S10ph in tumor cells of liver are significantly higher than in non-tumor cells. " 08/15/2013 - "It suggests that these binding sites may play a critical role in alcohol-induced deregulation of Pol III genes in liver tumor development." 03/01/2013 - "Indeed, Pol III transcripts accumulate in cancer cells and their heightened levels are implicated in accelerated growth associated with RB dysfunction. "

Related Drugs and Biologics

1.	RNA (Ribonucleic Acid)
2.	Transcription Factor TFIIIB
3.	Protein Kinases (Protein Kinase)
4.	tributyl phosphate (TBP)
5.	Proliferating Cell Nuclear Antigen (PCNA)
6.	RNA Polymerase III
7.	DNA (Deoxyribonucleic Acid)
8.	DNA Polymerase I (Klenow Fragment)
9.	Proteins (Proteins, Gene)
10.	DNA-Directed RNA Polymerases (RNA Polymerase)