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Type II DNA Topoisomerases (Topoisomerase II)

DNA TOPOISOMERASES that catalyze ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands. These enzymes bring about relaxation of the supercoiled DNA and resolution of a knotted circular DNA duplex.
Also Known As:
Topoisomerase II; DNA Topoisomerase (ATP-Hydrolysing); DNA Topoisomerases, Type II; DNA Topoisomerase II alpha; DNA Topoisomerase II beta; DNA Type 2 Topoisomerase; TOP2A Protein; TOP2B Protein; Topoisomerase II alpha; Topoisomerase II beta; Type II DNA Topoisomerase; alpha, Topoisomerase II; beta, Topoisomerase II; DNA Topoisomerase II
Networked: 1640 relevant articles (39 outcomes, 183 trials/studies)

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Bio-Agent Context: Research Results

Experts

1. Osheroff, Neil: 20 articles (01/2018 - 01/2003)
2. Nitiss, John L: 12 articles (01/2022 - 01/2002)
3. Felix, Carolyn A: 11 articles (03/2014 - 11/2003)
4. Bailly, Christian: 10 articles (01/2016 - 04/2003)
5. Austin, Caroline A: 8 articles (01/2019 - 06/2004)
6. Kondapi, Anand K: 8 articles (11/2017 - 05/2002)
7. Bailly, C: 8 articles (02/2014 - 06/2000)
8. Sehested, Maxwell: 8 articles (02/2010 - 04/2002)
9. Kwon, Youngjoo: 7 articles (10/2021 - 02/2010)
10. Hiasa, Hiroshi: 7 articles (01/2019 - 08/2006)

Related Diseases

1. Neoplasms (Cancer)
2. Breast Neoplasms (Breast Cancer)
3. Leukemia
4. Poisoning
5. Prostatic Neoplasms (Prostate Cancer)

Related Drugs and Biologics

1. Etoposide (VP 16)
2. trioctyl phosphine oxide (TOPO)
3. Anthracyclines
4. Poisons
5. Type I DNA Topoisomerases (Topoisomerase I)
6. Type II DNA Topoisomerases (Topoisomerase II)
7. Dexrazoxane (Zinecard)
8. DNA (Deoxyribonucleic Acid)
9. Doxorubicin (Adriamycin)
10. Tubulin

Related Therapies and Procedures

1. Drug Therapy (Chemotherapy)
2. Therapeutics
3. Aftercare (After-Treatment)
4. Castration
5. Remission Induction