Dithioerythritol

A compound that, along with its isomer, Cleland's reagent (DITHIOTHREITOL), is used for the protection of sulfhydryl groups against oxidation to disulfides and for the reduction of disulfides to sulfhydryl groups.

Also Known As:

Networked: 14 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Han, Hongmei: 1 article (01/2021)
2.	Hofnagel, Oliver: 1 article (01/2021)
3.	Konstantinidis, Georgios: 1 article (01/2021)
4.	Li, Zhiyu: 1 article (01/2021)
5.	Pantoom, Supansa: 1 article (01/2021)
6.	Voss, Stephanie: 1 article (01/2021)
7.	Wu, Yao-Wen: 1 article (01/2021)
8.	Abe, Akio: 1 article (10/2020)
9.	Goto, Masataka: 1 article (10/2020)
10.	Hanawa, Tomoko: 1 article (10/2020)

Related Diseases

1.	Neoplasms (Cancer) 01/01/1975 - " The addition of increasing concentrations of dithioerythritol (DTT) in the buffers was found to enhance progressively the affinity for binding in 4 of tumors. " 09/01/2013 - "Pre-incubation with the reducing agent dithioerythritol (DTE) showed a decrease in STK1 activity and protein levels in most samples, but an increase of about 20% in sera from healthy dogs and from those with haematological malignancies. " 07/01/1985 - "It was shown that both trypsin/dithioerythritol (TD) and collagenase/D Nase (CDse) were of value in dispersing single cells from tumor tissue. " 01/01/1986 - "Cell dispersion was performed overnight at 4 degrees C in two different enzyme mixtures, i.e., trypsin/dithioerythritol and collagenase/DNase, under slight agitation of sliced tumor tissue. " 01/01/2021 - ": ATG: autophagy-related; Cα: alpha carbon; CCD: coiled-coil domain; CLEM: correlative light and electron microscopy; DTE: dithioerythritol; EBSS: Earle's balanced salt solution; EDTA: ethylenediaminetetraacetic acid; EGFP: enhanced green fluorescent protein; FBS: fetal bovine serum; FLIM: fluorescence lifetime imaging microscopy; FRET: Förster resonance energy transfer; GDP: guanosine diphosphate; GOLGA2/GM130: golgin A2; GppNHp: guanosine 5'-[β,γ-imido]triphosphate; GST: glutathione S-transferase; GTP: guanosine triphosphate; GTPγS: guanosine 5'-O-[gamma-thio]triphosphate; HA (tag): hemagglutinin (tag); HEK: human embryonic kidney; HeLa: Henrietta Lacks; HEPES: (4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid); IgG: immunoglobulin G; Kd: dissociation constant; MAP1LC3/LC3: microtubule associated protein 1 light chain 3; MCF7: Michigan cancer foundation-7; MEF: mouse embryonic fibroblast; MEM: minimum essential medium Eagle; MST: microscale thermophoresis; NEAA: non-essential amino acids; PBS: phosphate-buffered saline; PE: phosphatidylethanolamine; PtdIns3P: phosphatidylinositol-3-phosphate; RAB: RAS-associated binding; RB1CC1/FIP200: RB1 inducible coiled-coil protein 1; RBP: RAB-binding protein; SD: standard deviation; SDS: sodium dodecyl sulfate; SQSTM1/p62: sequestosome 1; TBS-T: tris-buffered saline-tween 20; WD (repeat): tryptophan-aspartic acid (repeat); WIPI2B: WD repeat domain phosphoinositide interacting 2B; WT: wild type."
2.	Whooping Cough (Pertussis) 10/08/2020 - "pertussis in liquid medium containing other reducing agents such as 2-mercaptoethanol and dithioerythritol. "
3.	Pemphigus (Pemphigus Vulgaris) 01/01/1983 - "Scanning electron microscopic examination of human epidermal cells prepared from suction blister roofs by treatment with trypsin and dithioerythritol and incubated (37 degrees C, 18 hours) with pemphigus sera revealed a smooth or wrinkled surface texture in 83 to 96% and surface microvilli in only 17 to 4%. "
4.	Nephrosis 04/01/1975 - "Comparative study of dithioerythritol-reducible (DTE) disulfide bonds in glomerular basement membranes (GBM) isolated from normal rats and from similar groups of rats treated with the nephrosis-producing aminonucleoside of puromycin emphasize not only the importance of such linkages in the interaction and structural organization of the macromolecular GBM collagen-glycoprotein matrix but also suggest a modality by which GBM semi-permeability might be engendered. "
5.	Melanoma (Melanoma, Malignant) 03/01/1990 - "The antioxidant dithioerythritol was also found to inhibit tyrosinase activity and to block the growth inhibitory effects of 3,4-DHBA in pigmented melanoma cell lines. "

Related Drugs and Biologics

1.	Trypsin
2.	Reducing Agents
3.	Collagenases (Collagenase)
4.	Solutions
5.	Proteins (Proteins, Gene)
6.	Monophenol Monooxygenase (Tyrosinase)
7.	Tryptophan (L-Tryptophan)
8.	Sodium Dodecyl Sulfate (Sodium Lauryl Sulfate)
9.	Bovine Serum Albumin
10.	Salts

Related Therapies and Procedures

1.	Oral Administration