Disulfiram (Antabuse)

A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nausea, hypotension, and other symptoms (acetaldehyde syndrome). It acts by inhibiting aldehyde dehydrogenase.

Also Known As:

Networked: 1619 relevant articles (115 outcomes, 205 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Wang, Weiguang: 16 articles (01/2022 - 04/2003)
2.	Kosten, Thomas R: 14 articles (01/2021 - 04/2002)
3.	Ito, Yoshimasa: 12 articles (01/2015 - 02/2003)
4.	Dou, Q Ping: 10 articles (01/2019 - 11/2006)
5.	Nich, Charla: 10 articles (03/2016 - 03/2004)
6.	Nagai, Noriaki: 10 articles (01/2015 - 12/2007)
7.	Tang, Xing: 9 articles (06/2022 - 10/2013)
8.	Kast, Richard E: 9 articles (05/2022 - 02/2009)
9.	Petrakis, Ismene L: 9 articles (11/2017 - 03/2004)
10.	Mutschler, Jochen: 9 articles (10/2016 - 01/2008)

Related Diseases

1.	Alcoholism (Alcohol Abuse) 08/01/2007 - "This case highlights the potential dangers of disulfiram, a drug that can be beneficial in the short term, but not proven to improve long-term outcome in the treatment of alcoholism." 11/27/2023 - "Disulfiram use is an effective treatment for alcohol dependence. " 11/01/2012 - "Support for the efficacy of disulfiram was weaker, as it appeared effective only for those without a current alcohol use disorder for this sample." 05/01/2003 - "Controlled research has shown that supervised disulfiram is an effective treatment for alcoholism. " 01/01/1993 - "Disulfiram has been used effectively to deter alcohol consumption in patients with a history of alcohol abuse. "
2.	Cocaine-Related Disorders (Cocaine Addiction) 01/01/2019 - "Disulfiram has been beneficial in treating cocaine addiction in several studies. " 02/01/2013 - "A variant in the gene encoding DβH leads to reduced DβH activity, and as such, disulfiram might not be an effective treatment of cocaine dependence for individuals with this variant. " 04/01/2004 - "Converging evidence suggests that disulfiram is a promising treatment for cocaine dependence. " 01/01/2012 - "This study indicates that a patient's MTHFR genotype may be used to identify individuals who might show improved response to disulfiram treatment for cocaine dependence. " 07/01/2008 - "Disulfiram has demonstrated efficacy in six randomized clinical trials for the treatment of cocaine dependence, but is rarely used in clinical settings because of safety concerns. "
3.	Neoplasms (Cancer) 10/05/2020 - "Disulfiram (DSF) is an FDA-approved anti-alcoholic drug that has recently proven to be effective in cancer treatment. " 11/01/2022 - "Disulfiram (DSF) is a clinical antialcoholism drug that has been confirmed to show anticancer bioactivity after chelating with Cu2+. Therefore, how to co-deliver DSF and Cu2+ to tumor tissues and generate a smart response to the tumor microenvironment (TME) are the focus of repurposing DSF for the effective treatment of cancer. " 01/01/2021 - "This result is helpful for the formulation of clinical dosage regimens of disulfiram in cancer treatment." 02/01/2016 - "The anti-tumor efficacy of the anti-alcoholic drug disulfiram has been known for some time. " 10/15/2013 - "However, disulfiram has complex pharmacokinetics and is rapidly eliminated which limits its use as a tumor treatment. "
4.	Fibrosis (Cirrhosis) 07/01/2000 - "The second part of the study included 13 alcoholic patients with clinical or pathological evidence of cirrhosis who also were administered disulfiram for 2 weeks. " 01/01/2022 - "Corrigendum: Disulfiram suppressed peritendinous fibrosis through inhibiting macrophage accumulation and its pro-inflammatory properties in tendon bone healing." 01/01/2022 - "Disulfiram Suppressed Peritendinous Fibrosis Through Inhibiting Macrophage Accumulation and Its Pro-inflammatory Properties in Tendon Bone Healing." 12/01/2021 - "The FDA-approved drug disulfiram might improve fibrosis in DKD by targeting tubular pyroptosis and VCAM1 expression." 07/01/2000 - "Disulfiram should be given cautiously, especially in patients with cirrhosis."
5.	Infections 01/01/2019 - "fortuitum infection model, disulfiram caused significant reduction in bacterial load in kidneys. " 11/15/2022 - "Disulfiram Is Effective against Drug-Resistant Mycobacterium abscessus in a Zebrafish Embryo Infection Model." 11/15/2022 - "abscessus infection in vivo and strongly support further study of disulfiram in human NTM infections." 06/01/1998 - "This study examines the effects of disulfiram in alcohol-dependent patients with elevated liver function test results and/or serologic evidence of hepatitis C virus (HCV) infection. " 01/01/2019 - "Finally, disulfiram's in vivo potential was determined in a neutropenic murine model mimicking mycobacterial infection. "

Related Drugs and Biologics

1.	Disulfiram (Antabuse)
2.	Naltrexone (ReVia)
3.	Cocaine (Cocaine HCl)
4.	Copper
5.	Acamprosate (Campral)
6.	Methadone (Dolophine)
7.	Enzymes
8.	Aldehyde Dehydrogenase
9.	Dopamine beta-Hydroxylase
10.	Chelating Agents

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Secondary Prevention
4.	Oral Administration
5.	Chelation Therapy (Therapy, Chelation)