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Cromolyn Sodium (Cromoglicic Acid)

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A chromone complex that acts by inhibiting the release of chemical mediators from sensitized mast cells. It is used in the prophylactic treatment of both allergic and exercise-induced asthma, but does not affect an established asthmatic attack.

Also Known As:

Cromoglicic Acid; Intal; Nasalcrom; Opticrom; Sodium Cromoglycate; Aarane; Bicromat Spray; Cromoglycate; Cromoglycic Acid; Cromolyn; FPL-670; Lomudal; Nalcrom; Vicrom; Cromoglycate, Disodium; Cromoglycate, Sodium; FPL 670; FPL670; Disodium Cromoglycate; 4H-1-Benzopyran-2-carboxylic acid, 5,5'-((2-hydroxy-1,3-propanediyl)bis(oxy))bis(4-oxo-, disodium salt)

Networked: 1575 relevant articles (174 outcomes, 263 trials/studies)

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Drug Context: Research Results

Experts

1.	Kim, Sang-Hyun: 4 articles (02/2014 - 05/2006)
2.	Gan, Xiao-liang: 4 articles (10/2012 - 05/2007)
3.	Hei, Zi-qing: 4 articles (10/2012 - 05/2007)
4.	de Jongste, J C: 4 articles (01/2006 - 11/2000)
5.	König, P: 4 articles (03/2002 - 02/2000)
6.	Shin, Tae-Yong: 3 articles (02/2014 - 05/2006)
7.	Wang, Jing: 3 articles (08/2013 - 08/2011)
8.	Anderson, Sandra D: 3 articles (01/2011 - 05/2010)
9.	Shen, Ning: 3 articles (03/2009 - 05/2007)
10.	Korppi, Matti: 3 articles (06/2008 - 02/2002)

Related Diseases

1.	Asthma (Bronchial Asthma) 03/01/2006 - "Significant between-period intervention differences showed improvement of clinical outcomes for children with severe asthma during the five years of sodium cromoglycate inhalation. " 01/01/1989 - "The results indicate that sodium cromoglycate administered by pressurized aerosol at a dose of 2 x 1 mg or 2 x 5 mg 4-times daily is effective in the treatment of asthma and suggest that the higher dose formulation may provide more rapid control of symptoms." 07/01/1999 - "The HFA formulation of cromolyn sodium MDI is a well-tolerated and effective treatment for asthma patients > or = 12 years old. " 07/01/1993 - "Disodium cromolyn is effective in preventing asthma, but its steroid sparing effect remains controversial. " 01/01/1987 - "Cromolyn is effective for controlling the symptoms of mild to moderate chronic asthma in 60 to 70 percent of patients. "
2.	Allergic Conjunctivitis (Giant Papillary Conjunctivitis) 02/01/1988 - "Cromolyn sodium was found to be significantly more effective than placebo in treating the signs and symptoms of vernal keratoconjunctivitis (VKC). " 01/01/1992 - "One of the main objectives of any therapy is to reduce the frequency of dosage and the current study has been designed to investigate the efficacy of a 4% solution of Sodium Cromoglycate, used twice daily, versus a 2% solution used four times daily in seasonal allergic conjunctivitis. " 11/01/2011 - "Cromolyn 2 % ophthalmic solution was effective and safe to treat allergic conjunctivitis. " 02/01/1982 - "Vernal keratoconjunctivitis (VKC) is usually considered as an allergic eye disorder of type I, and in most therapeutic trials it has been shown to yield to topical treatment with sodium cromoglycate. " 07/01/1981 - "Previous studies have shown the effectiveness of topical cromolyn solution in the treatment of allergic conjunctivitis. "
3.	Rhinitis 04/01/2002 - "Intranasal cromolyn has an excellent safety record, is available as an over-the-counter medication, and has been proved to be efficacious in patients with allergic rhinitis." 08/01/1984 - "3) Disodium cromoglycate is not universally effective in chronic rhinitis, perhaps in part because compliance with a prophylactic drug requiring insufflation four or six times daily may not be high. " 03/01/1977 - "A large-scale multicenter investigation was undertaken in 3 cities with comparable pollen seasons and atmospheric pollen concentrations in order to obtain more definite information about the safety and efficacy of cromolyn sodium in the treatment of pollen-induced seasonal rhinitis. " 11/01/1988 - "Nasal cromolyn is effective for many patients with allergic rhinitis, but its effect is variable and it is useful in severe allergic rhinitis." 06/01/2002 - "The goal of the study was to evaluate the efficacy of cromolyn sodium 4% nasal solution for the treatment of allergic rhinitis in self-selected patients in a nonprescription setting. "
4.	Exercise-Induced Asthma (Asthma, Exercise Induced) 09/01/1996 - "Hypotonic disodium cromoglycate seems to be clinically effective for prevention of exercise-induced bronchospasm and treatment of asthmatic children." 09/01/1996 - "We conclude that the efficacy of hypotonic and isotonic disodium cromoglycate solutions is similar for protection against exercise-induced bronchospasm. " 01/01/1984 - "Eight patients with exercise-induced asthma participated in a single blind dose-duration study comparing the protective effect of inhaled sodium cromoglycate (SCG) in increasing concentrations from 2 to 40 g/l. " 09/01/1982 - "Ten patients with exercise-induced asthma participated in a single-blind dose-response study comparing the protective effect of inhaled sodium cromoglycate in increasing concentrations from 2 to 40 mg/ml. Saline was used as a control. " 09/01/1982 - "Dose-response study of sodium cromoglycate in exercise-induced asthma."
5.	Pruritus (Itching) 04/01/2006 - "Two patients with disabling uremic pruritus refractory to multiple interventions are reported, who showed significant improvement in pruritus severity as assessed by a visual analog scale when they were treated with the mast cell stabilizer cromolyn sodium. " 07/01/2012 - "Efficacy of topical cromolyn sodium 4% on pruritus in uremic nephrogenic patients: a randomized double-blind study in 60 patients." 04/01/2006 - "Cessation of cromolyn resulted in return of pruritus, which improved with rechallenge with the medication. " 12/01/1998 - "Itching, oedema and hyperaemia are relieved with topical H1-antagonists or sodium cromoglycate. " 07/01/2012 - "According to our study cromolyn sodium cream 4% was more effective than placebo in reducing pruritus in uremic patients. "

Related Drugs and Biologics

1.	Cromolyn Sodium (Cromoglicic Acid)
2.	Nedocromil (Alocril)
3.	Ketotifen (Ketotifene)
4.	Beclomethasone (Beclometasone)
5.	Adrenal Cortex Hormones (Corticosteroids)
6.	Steroids
7.	lodoxamide ethyl (lodoxamide)
8.	Immunoglobulin E (IgE)
9.	Ophthalmic Solutions (Eye Drops)
10.	Ipratropium (Ipratropium Bromide)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Immunotherapy
3.	Aftercare (After-Treatment)
4.	Metered Dose Inhalers (Metered Dose Inhaler)
5.	Nebulizers and Vaporizers (Inhaler)