Disease Susceptibility (Diathesis)

A constitution or condition of the body which makes the tissues react in special ways to certain extrinsic stimuli and thus tends to make the individual more than usually susceptible to certain diseases.

Also Known As:

Networked: 2443 relevant articles (50 outcomes, 262 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Hemorrhage
2.	Asthma (Bronchial Asthma)
3.	Infection
4.	Liver Diseases (Liver Disease)
5.	Calculi (Calculus)

Experts

1.	Knip, Mikael: 9 articles (06/2014 - 02/2004)
2.	Ilonen, Jorma: 7 articles (06/2014 - 02/2004)
3.	Reveille, John D: 7 articles (06/2013 - 05/2005)
4.	Nakamura, Yusuke: 7 articles (01/2013 - 01/2002)
5.	Preminger, Glenn M: 7 articles (10/2007 - 08/2002)
6.	Ota, Masao: 5 articles (01/2014 - 08/2010)
7.	Veijola, Riitta: 5 articles (10/2013 - 12/2005)
8.	Simell, Olli: 5 articles (10/2013 - 02/2004)
9.	Ramagopalan, Sreeram V: 5 articles (01/2013 - 01/2009)
10.	Pak, Charles Y C: 5 articles (09/2008 - 11/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Disease Susceptibility:

1.	Biological Markers (Surrogate Marker)IBA 01/01/2002 - "Genetic biomarkers for disease susceptibility including both Mendelian and complex disease promise to result in improved understanding of the pathophysiology of disease, identification of new potential therapeutic targets, and improved molecular classification of disease. " 12/01/2014 - "The authors review and synthesize the research literature on biomarkers of suicide, with the aim of using the findings of these studies to develop a coherent model for the biological diathesis for suicide. " 10/01/2014 - "All the alterations highlighted in this study considered together may be effective biomarkers of stress and disease susceptibility. " 10/01/2013 - "Recent studies have highlighted the important role that protein truncating variants, commonly referred to as 'loss of function' variants, may have on disease susceptibility and quantitative levels of biomarkers. " 10/01/2011 - "Our study indicates that XRCC1 haploinsufficiency in mammals has little effect on chronological longevity and many key biological markers of aging in the absence of environmental challenges, but may adversely affect normal animal development or increase disease susceptibility to a relevant genotoxic exposure."
2.	recombinant FVIIa (rFVIIa)IBA 05/01/2007 - "A computer-assisted search of the MEDLINE, EMBASE, and CENTRAL (Cochrane Central Register of Controlled Trials) electronic databases up to July 2006 to identify published randomised controlled trials (RCTs) that evaluated the effect of rfVIIa as prophylaxis and/or treatment of bleeding episodes in patients without inherited haemostatic diathesis. " 05/01/2002 - "A large number of case reports and results from initial clinical trials suggest that rFVIIa may also be effective in the prevention and treatment of bleeding in patients under oral anticoagulation, with liver diseases, and in patients without any pre-existing haemorrhagic diathesis. " 03/01/2012 - "In patients with a bleeding diathesis, like hemophilia, the main importance of TG assays lies in the application for monitoring replacement therapy, either with factor concentrate or rFVIIa. " 03/01/2002 - "A novel approach to treating the bleeding diathesis of patients with cirrhosis is administration of recombinant factor VIIa (rFVIIa). " 10/01/2006 - "Recombinant factor VIIa (rFVIIa) is a highly efficacious therapy initially used to treat the bleeding diathesis of hemophiliac patients that has recently gained a wider role in the treatment of liver disease, thrombocytopenia, and intracerebral and traumatic hemorrhage. "
3.	Proteins (Proteins, Gene)IBA 10/01/2005 - "truncatula accessions with altered disease susceptibility, whereof proteins with increased abundances in the more resistant line F83.005-9 could be involved in mechanisms that lead to an improved disease resistance. " 01/01/2007 - "Genes or proteins identified as significantly changing in proteomic experiments, or identified as susceptibility disease genes in genomic studies, can be placed in the context of protein interaction networks in order to assign these genes and proteins to pathways and protein complexes. " 05/15/2003 - "The concepts include both experimental and computational approaches that could be employed to develop predictors of disease susceptibility based on DNA repair genotype, focusing initially on studies to assess functional impact on individual proteins and pathways and then on molecular epidemiology studies to assess exposure-dependent health risk. " 04/15/2015 - "The expression level of HLA class-I proteins is known to influence pathological outcomes: pathogens downregulate HLA to evade host immune responses, host inflammatory reactions upregulate HLA, and differences among people with regard to the steady-state expression levels of HLA associate with disease susceptibility. " 03/01/2015 - "Enhanced disease susceptibility 1 (EDS1) in Arabidopsis thaliana serves as a central node protein for basal immune resistance and ETI by interacting dynamically with other immune regulatory or resistance proteins. "
4.	Heparin (Liquaemin)FDA LinkGeneric 07/29/1950 - "[Heparin activity in thrombophilic diathesis]." 03/01/1999 - "After he had received blood component therapy, including fresh frozen plasma and cryoprecipitate concentrates, and intravenous heparin infusion (10,000 U/day), the bleeding diathesis and coagulopathy improved. " 07/01/2014 - "By reducing coagulation activation, anticoagulant treatment with heparin is able to limit this haemostatic dysregulation and the associated bleeding diathesis. " 04/01/2012 - "This diathesis may respond well to heparin administration, suggesting that heparin administration in ruptured aneurysms is appropriate." 01/01/2009 - "Six of the seven patients with PRES-related ICH had underlying bleeding diathesis, including one patient who was anti-coagulated with a heparin drip. "
5.	Deamino Arginine Vasopressin (Desmopressin)FDA LinkGeneric 06/01/2000 - "Two different desmopressin (DDAVP) regimens in enuretic monozygotic twins with allergic diathesis." 11/23/1989 - "Previous studies have suggested that desmopressin may reduce the bleeding diathesis that often complicates open-heart surgery. " 02/01/2006 - "Desmopressin (DDAVP) is a well tolerated and convenient haemostatic agent that can be used in a number of clinical conditions with bleeding diathesis. " 09/01/1999 - "Treatment of the bleeding diathesis was successfully achieved with desmopressin or clotting factor concentrates. " 03/01/1997 - "Desmopressin is suitable for home use in selected patients with bleeding diathesis. "
6.	AntigensIBA 01/01/2012 - "While genome studies map a strong MS susceptibility effect to the region of DRB1*1501, our findings offer a rationale for potential involvement of pathogenic DQ6-associated autoimmunity in MS. Moreover, that DQB1*0602, but not DRB1*1501, determines disease-susceptibility to PLP in HLA-transgenics, suggests a potential differential, functional role for DQB1*0602 as a predisposing allele in MS. This, together with previously demonstrated disease-susceptibility to MBP and MOG in DRB1*1501-transgenics, also suggests a differential role for DRB1*1501 and DQB1*0602 depending on target antigen and imply a potential complex 'genotype/target antigen/phenotype' relationship in MS heterogeneity." 02/01/2006 - "Human leukocyte antigen (HLA) association studies of these populations could improve knowledge on inter-population variation and HLA-related disease susceptibility. " 08/01/1990 - "These studies have been particularly informative in elucidating 1) mechanisms whereby immune tolerance is maintained to antigens on rare specialized cells such as the pancreatic beta-cell, 2) disease susceptibility and resistance genes, and 3) potentially important immune effector mechanisms. " 02/01/1984 - "Identification of these target antigens, their isolation, and purification will allow further study of the nature of the immune diathesis and permit development of specific therapy designed to eliminate the malregulated clones of immunocytes. " 06/01/2013 - "The human leucocyte antigen (HLA) has been documented to be involved in various disease susceptibilities or in resistance against certain diseases. "
7.	DNA (Deoxyribonucleic Acid)IBA 03/01/2002 - "This proposal has begun to be tested in numerous studies of association between genetic variation at these common DNA polymorphisms and variation in disease susceptibility. " 08/01/1991 - "Thus, association studies between DNA polymorphisms at this locus and disease susceptibility genes could well be feasible in this population. " 01/01/2015 - "DNA copy number variants (CNVs) that alter the copy number of a particular DNA segment in the genome play an important role in human phenotypic variability and disease susceptibility. " 03/01/2014 - "The Moroccan Genetic Disease Database (MGDD): a database for DNA variations related to inherited disorders and disease susceptibility." 12/01/2013 - "Over the last 6 years, large multicenter DNA collections have thrived and the development of new laboratory and analytical approaches has matured at a remarkable pace, allowing pursuit of comprehensive 'agnostic' genome-wide association studies to identify and characterise the non-MHC genetic component of MS. Taken together, the results have provided unambiguous evidence for the association of over 100 non-MHC loci with disease susceptibility. "
8.	AntibodiesIBA 11/01/2013 - "The goal of this study was to demonstrate, using the largest cohort reported so far, that mothers of an ASD child have an elevated frequency of anti-brain antibodies and to assess whether brain reactivity is associated with an autoimmune diathesis of the mother. " 01/01/2010 - "Ever since the development of Hybridoma Technology in 1975 by Kohler and Milstein, our vision for antibodies as tools for research for prevention, detection and treatment of diseases, vaccine production, antigenic characterization of pathogens and in the study of genetic regulation of immune responses and disease susceptibility has been revolutionized. " 04/01/1984 - "These studies confirm that immunity to cutaneous disease in a normally resistant mouse strain (C3H/HeJ) is independent of antibody, but that B cells and/or antibodies are required for the evolution of suppressed DTH and the consequent disease susceptibility of BALB/c mice. " 07/01/2015 - "Therefore, the vaccination timing should be based on factors such as the interference of maternal antibodies, disease susceptibility period, and immune maturation." 02/01/2015 - "The GTG haplotype was significantly associated with: RA susceptibility; disease onset at ≤ 40 years and anti-CCP antibodies. "
9.	HLA Antigens (Human Leukocyte Antigens)IBA 01/01/2009 - "Several studies demonstrated the association of various human leukocyte antigens (HLA) with disease susceptibility in different ethnic populations. " 07/01/2000 - "HLA antigens were found to be of importance in anthropologic and disease susceptibility studies. " 02/01/2014 - "It is now over forty years since the first associations between particular HLA antigens and disease susceptibility were described, and the identification of large numbers HLA-associated diseases parallels our increased understanding of the genetic complexity of the HLA system and its extensive polymorphism. " 10/01/2004 - "Previous work showed an association of the hemorrhagic form with human leukocyte antigens (HLA), suggesting a role of genetic factors in disease susceptibility. " 01/01/2001 - "Part III. The relationship between HLA antigens and disease susceptibility]."
10.	Interleukin-6 (Interleukin 6)IBA 05/01/2011 - "This study examines the association of TB disease susceptibility with a selection of biologically relevant genes on regions on chromosomes 7 (IL6 and CARD11) and 20 (CTSZ and MC3R) and fine mapping of the chromosome 7p22-p21 region identified through our genome scan. " 02/01/2011 - "In the present study, the relationship between two polymorphisms in the promoter region of IL-6 gene at positions -572 G/C and -174 G/C and disease susceptibility in 401 Iranian patients with SLE was investigated using polymerase chain reaction-restriction fragment length polymorphism method. " 03/01/2005 - "The aim of the present study was to examine the interleukin-6 (IL-6) -174 promoter polymorphism in patients with RA and its association with disease susceptibility and activity. " 07/01/2014 - "Our data suggest that IL-6 gene polymorphisms play a prominent role in T2DM disease susceptibility in population from north India." 11/01/2013 - "There is accumulating evidence that the IL-6 promoter, receptor and signal transducer SNPs can modify disease susceptibility."

Therapies and Procedures

1.	Solid-State Lasers 05/01/2012 - "All articles reporting on treatment for stones in patients with a bleeding diathesis using ureteroscopy and a Holmium:YAG laser were included. " 10/01/1998 - "Use of the holmium laser with ureteroscopic access provides a safe and acceptable combination for treating upper tract pathology in patients with uncorrected bleeding diatheses. " 10/01/1998 - "Use of ureteroscopy and holmium:YAG laser in patients with bleeding diatheses." 09/01/2002 - "Safety and efficacy of holmium: YAG laser lithotripsy in patients with bleeding diatheses." 08/01/2002 - "Safety and efficacy of holmium: YAG laser lithotripsy in patients with bleeding diatheses."
2.	Lithotripsy (Extracorporeal Shockwave Lithotripsy) 04/01/2006 - "Lower pole stones less than 20 mm can be primarily treated by ureteroscopic means in patients: that are obese; have a bleeding diathesis; with stones resistant to shockwave lithotripsy (SWL); with complicated intra-renal anatomy; or as a salvage procedure after failed SWL. " 09/01/2002 - "Safety and efficacy of holmium: YAG laser lithotripsy in patients with bleeding diatheses." 08/01/2002 - "Safety and efficacy of holmium: YAG laser lithotripsy in patients with bleeding diatheses." 05/01/2012 - "Retrograde stone treatment using ureteroscopy and holmium laser lithotripsy can be safely performed in patients with bleeding diathesis with a low complication rate." 05/01/2012 - "Flexible ureteroscopy and holmium:YAG laser lithotripsy for stone disease in patients with bleeding diathesis: a systematic review of the literature."
3.	Transplants (Transplant) 01/01/1998 - "Early recurrence of disease is most common in individuals with Dupuytren's diathesis; use of full-thickness skin grafts may be helped for these patients." 07/01/2015 - "The grouping of HLA molecules achieved here will be useful for rational vaccine design, understanding disease susceptibilities and predicting risk of organ transplants. " 02/01/2012 - "This differentiation approach will have broad applications in modeling origin-dependent disease susceptibility and in developing bioengineered vascular grafts for regenerative medicine." 06/01/2005 - "Because the NOD MHC class II allele, I-A(g7), is the primary disease susceptibility gene, it is logical to conclude that MHC-mismatched hematopoietic grafts prevent diabetes by replacement of this susceptibility allele on critical hematolymphoid populations. " 09/01/1984 - "The atherogenic diatheses of young adults may compromise the operative result, whereas use of internal mammary artery grafts may enhance the palliation of bypass surgery."
4.	Blood Transfusion (Blood Transfusions) 08/01/1980 - "Fresh blood stored not longer than 12 hours is only indicated in massive blood transfusion and in acute blood loss due to not yet cleared up haemorrhagic diatheses. " 11/01/1960 - "Two cases of haemorrhagic diathesis are described, where the laboratory diagnosis was confused owing to previous blood transfusions. " 01/01/2014 - "There was neither history of blood transfusion or nasal packing, nor a history suggestive of bleeding diathesis. " 01/01/1985 - "By means of the Central Card Index of Haemophilia, a working material of the Section of Haemophilia in the Society of Haematology and Blood Transfusion of the GDR, 52 patients with heriditary haemorrhagic diatheses could be registered. " 12/01/1981 - "[Effect of different blood transfusion media on the immunoreactivity and allergic diathesis of infants with anemias]."
5.	Local Anesthesia 03/01/2014 - "A total of 147 patients with bleeding diathesis circumcised under local anesthesia by using diathermic knife between 1996 and 2010 were recruited into this study. " 03/01/1982 - "Embolization via the umbilical vein can be performed with a patient under local anesthesia, can be effective when other methods fail, and can be done safely in the presence of both ascites and a bleeding diathesis, which are two contraindications to PTCVO."