Animal Disease Models

Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.

Also Known As:

Networked: 116 relevant articles (12 outcomes, 26 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Inflammation
2.	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental)
3.	Demyelinating Diseases (Demyelinating Disease)
4.	Neoplasms (Cancer)
5.	Vascular System Injuries

Experts

1.	Lu, Patrick Y: 3 articles (01/2008 - 01/2005)
2.	Woodle, Martin C: 3 articles (01/2008 - 01/2005)
3.	Jeng, Arco Y: 2 articles (01/2014 - 07/2004)
4.	Honma, Kimi: 2 articles (05/2007 - 10/2006)
5.	Takeshita, Fumitaka: 2 articles (05/2007 - 10/2006)
6.	Ochiya, Takahiro: 2 articles (05/2007 - 10/2006)
7.	Lee, C Justin: 1 article (10/2015)
8.	Olsen, Michelle L: 1 article (10/2015)
9.	Skatchkov, Serguei N: 1 article (10/2015)
10.	Zhou, Min: 1 article (10/2015)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Animal Disease Models:

1.	Small Interfering RNA (siRNA)IBA 11/10/2014 - "In addition, this review provides specific information on poly-siRNA delivery systems from basics to therapeutic applications in different animal disease models." 01/01/2008 - "In vivo delivery of siRNA is complicated and challenging, and recent works on various animal disease models and early successes in human clinical trials are enlightening the tremendous potential of RNAi therapeutics. " 03/01/2005 - "This article describes the latest developments using small-interfering RNA (siRNA) inhibitors to downregulate various angiogenic and tumor-associated factors, both in cell-culture assays and in animal disease models. " 10/01/2006 - "We report here the efficacy of an atelocollagen-mediated oligonucleotide delivery system applied to systemic siRNA and antisense oligonucleotide treatments in animal disease models. "
2.	VaccinesIBA 04/01/2014 - "Common tactical problems of human protozoal vaccine research include reliance upon adapted rather than natural animal disease models, and an overwhelming emphasis on novel approaches that are usually attempted in replacement of rather than for improvement upon the types of designs used in effective veterinary vaccines. " 09/01/2000 - "Although the first generation of DNA plasmid vaccines were broadly effective in animal disease models, early clinical immunogenicity pointed towards the need for increased potency. " 08/01/1994 - "Particularly encouraging are live recombinant vaccines, studies demonstrating the potential to elicit both systemic and mucosal immune responses, more studies demonstrating immune protection in animal disease models, and experimental vaccines eliciting immune responses in primates." 09/01/2004 - "Experimental vaccines based on recombinant vesicular stomatitis viruses (VSV) expressing foreign viral proteins are protective in several animal disease models. "
3.	Transforming Growth Factor beta (TGF-beta)IBA 04/01/1992 - "This is the first study showing that TGF-beta can potentiate the development and maintenance of the Th cell memory phenotype in vitro and enhance their in vivo effector function in an animal disease model." 01/01/1991 - "Importantly, the administration of TGF-beta has proven beneficial in several animal disease models such as septic shock, allograft rejection, and autoimmunity. "
4.	Propolis (Bee Bread)IBA 04/01/2015 - "In this study, we examined if caffeic acid phenethyl ester (CAPE), a skin-permeable bioactive compound from propolis, was protective against skin inflammation using in vitro cell system and in vivo animal disease models. "
5.	HydrogenIBA 04/01/2015 - "In the past 2 decades, molecular hydrogen emerged as a novel therapeutic agent, with antioxidant, anti-inflammatory and anti-apoptotic effects demonstrated in plethora of animal disease models and human studies. "
6.	tebufenozide (Mimic)IBA 01/01/2012 - "In the present study, we examined the efficacy of intraventricularly injected NSCs in chronic relapsing experimental autoimmune encephalomyelitis (CREAE), the animal disease model that is widely accepted to mimic most closely recurrent inflammatory demyelination lesions as observed in relapsing-remitting MS. In addition, we assessed whether priming these NSCs to become oligodendrocyte precursor cells (OPCs) by transient overexpression of Olig2 would further promote functional recovery, for example, by contributing to actual remyelination. "
7.	caffeic acid phenethyl esterIBA 04/01/2015 - "In this study, we examined if caffeic acid phenethyl ester (CAPE), a skin-permeable bioactive compound from propolis, was protective against skin inflammation using in vitro cell system and in vivo animal disease models. "
8.	DNA (Deoxyribonucleic Acid)IBA 01/01/2013 - "The in vivo transfer of naked plasmid DNA into organs such as muscles is commonly used to assess the expression of prophylactic or therapeutic genes in animal disease models. " 09/01/2000 - "Although the first generation of DNA plasmid vaccines were broadly effective in animal disease models, early clinical immunogenicity pointed towards the need for increased potency. " 01/01/2009 - "Since the first report almost two decades ago, where it was demonstrated that gene expression is possible by directed injection of naked DNA, DNA vaccines have been proven to induce protective immune responses against parasites, virus and bacterium in diverse animal disease models. "
9.	rho-Associated KinasesIBA 01/01/2004 - "Inhibitors of Rho kinase were shown to be effective in ameliorating hypertension, vasospasm, vascular injury and associated organ damages in various animal disease models. "
10.	imatinib (Gleevec)FDA Link 04/01/2009 - "Indeed, imatinib has been shown to be effective in various animal disease models for arthritis, interstitial pneumonia, glomerulonephritis, and pulmonary hypertension. "

Therapies and Procedures

1.	Therapeutics 01/01/2015 - "PTDs/CPPs have shown great potential to deliver otherwise undeliverable macromolecular therapeutics into cells for experimentation in cell culture and in animal disease models in vivo. " 05/01/2007 - "RNAi has rapidly become a powerful tool for drug target discovery and validation in an in vitro culture system and, consequently, interest is rapidly growing for extension of its application to in vivo systems, such as animal disease models and human therapeutics. " 01/01/2005 - "Consequently, interest is rapidly growing for extension of its application to in vivo systems, such as animal disease models and human therapeutics. " 12/01/2010 - "Recently, the efficacy of SSOs has been established in various animal disease models; however, the application of SSOs against cancer targets has been hindered by poor in vivo delivery of antisense therapeutics to tumor cells. " 05/01/2007 - "The aim of this review is to analyze how our knowledge on the etiology, pathology, and treatment of amyotrophic lateral sclerosis (ALS) has profited from the application of biotechnology tools for the identification of disease markers, the development of animal disease models, and the design of innovative therapeutics. "
2.	Homologous Transplantation (Allograft) 01/01/1991 - "Importantly, the administration of TGF-beta has proven beneficial in several animal disease models such as septic shock, allograft rejection, and autoimmunity. "
3.	Photochemotherapy (Photodynamic Therapy) 05/01/2009 - "We have suggested the application of photodynamic therapy (PDT) as a new treatment for airway stenosis and have determined the efficacy of PDT in animal disease models using a second-generation photosensitizer with reduced photosensitivity. "
4.	Immunotherapy 01/01/2012 - "In this review, we detailed the rationale and the requirements for the use of AC immunotherapies in humans, the proof of efficacy of these medications in animal disease models, and their current clinical development and outcome, including adverse side effects they may generate. "
5.	Bioreactors 03/01/2013 - "Further studies will allow transgenic technology to explore gene function, animal genetic improvement, bioreactors, animal disease models, and organ transplantation. " 06/01/2010 - "With the in-depth research, the transgenic technology will have broad application prospects in the fields of exploration of gene function, animal genetic improvement, bioreactor, animal disease models, organ transplantation and so on. "