Diquat

10/01/2015 - "Diquat may, therefore, kill neural tissue by programmed necrosis rather than apoptosis, reflecting the pathological changes seen following high-level exposure, although its ability to promote PD is unclear. "
10/01/2012 - "Diquat produced liver injury in Nrf2-null mice, as evidenced by increased serum ALT activity and extensive hepatic necrosis, but not in wild-type and Keap1-KD mice. "
03/01/2009 - "Despite the activation of JNK after high doses of diquat, the JNK inhibitor SP-600125 did not protect against diquat-induced necrosis. "
03/01/2000 - "Sex differences in diquat-induced hepatic necrosis and DNA fragmentation in Fischer 344 rats."
08/01/1988 - "Hepatic necrosis is produced rapidly by 0.1 mmol/kg diquat in male Fischer-344 rats but not Sprague-Dawley rats, yet massive oxidant stress is caused by diquat in both strains of rat. "

05/01/2009 - "A trial was performed to evaluate the efficacy of diquat (6,7-dihydrodipyrido[1,2-a:2',1'-c]pyrazinediium dibromide) against an acute experimental infection of Flavobacterium columnare in channel catfish, Ictalurus punctatus. "
05/01/2009 - "The results demonstrate that diquat would reduce mortalities caused by an acute columnaris infection."
05/01/2009 - "Evaluation of diquat against an acute experimental infection of Flavobacterium columnare in channel catfish, Ictalurus punctatus (Rafinesque)."

01/01/2014 - "On day 8, the piglets were injected intraperitoneally with sterile 0.9% NaCl solution or diquat (10 mg/kg body weight). "
06/28/2013 - "On day 8, piglets were injected intraperitoneally either with diquat (10 mg/kg body weight) or sterile saline. "
07/01/2007 - "After injection with 0.1 mmol diquat/kg body weight, survival time was markedly shorter in Fischer-344 rats fed a purified diet than in rats fed a regular diet, and much more severe hepatotoxicity and nephrotoxicity were observed in the former than in the latter. "
11/01/1999 - "Lethality and hepatic biochemical indicators in GPX1 knockout mice [GPX1(-/-)] were compared with those of wild-type mice (WT) after an intraperitoneal injection of diquat at 6, 12, 24, or 48 mg/kg of body weight. "
01/01/2015 - "Diquat injection significantly reduced growth performance, including body weight, average daily weight gain, and feed intake (P<0.05). "

02/01/1981 - "Plasma paraquat, after ion-pair extraction and dithionite reduction, yields a sharp, stable absorption peak at 396 nm. Derivative spectroscopy confers enhanced sensitivity (detection limit, 5 microgram/L) and improved rejection of spectroscopic interference by diquat, hemolysis, bilirubin, or lipemia. "

02/01/1981 - "Plasma paraquat, after ion-pair extraction and dithionite reduction, yields a sharp, stable absorption peak at 396 nm. Derivative spectroscopy confers enhanced sensitivity (detection limit, 5 microgram/L) and improved rejection of spectroscopic interference by diquat, hemolysis, bilirubin, or lipemia. "