Diphtheria Toxoid (Vaccine, Diphtheria)

The formaldehyde-inactivated toxin of Corynebacterium diphtheriae. It is generally used in mixtures with TETANUS TOXOID and PERTUSSIS VACCINE; (DTP); or with tetanus toxoid alone (DT for pediatric use and Td, which contains 5- to 10-fold less diphtheria toxoid, for other use). Diphtheria toxoid is used for the prevention of diphtheria; DIPHTHERIA ANTITOXIN is for treatment.

Also Known As:

Networked: 427 relevant articles (13 outcomes, 45 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Centers for Disease Control and Prevention (CDC): 14 articles (02/2015 - 10/2006)
2.	Broder, Karen R: 9 articles (12/2015 - 03/2006)
3.	Kretsinger, Katrina: 6 articles (09/2009 - 03/2006)
4.	Friedland, Leonard R: 5 articles (02/2012 - 04/2006)
5.	Weston, Wayde M: 5 articles (02/2012 - 11/2008)
6.	Nohynek, Hanna: 5 articles (06/2009 - 04/2002)
7.	Puumalainen, Taneli: 5 articles (06/2009 - 04/2002)
8.	Omer, Saad B: 4 articles (01/2016 - 11/2012)
9.	Moro, Pedro L: 4 articles (12/2015 - 11/2011)
10.	Klein, Nicola P: 4 articles (11/2015 - 11/2008)

Related Diseases

1.	Diphtheria 02/01/2000 - "This study suggests that one dose of 2 Lf diphtheria toxoid is highly effective in raising DAT to protective levels in most adults; however, the study also shows that certain age groups, particularly persons 40-49 and, to a lesser degree, 30-39 years old may require additional doses or a complete three-dose primary vaccination series for optimal protection against diphtheria." 02/19/1983 - "We conclude that adults should not be vaccinated without previous screening for susceptibility to diphtheria; that neither previous immunisation nor age is reliable in predicting the need for vaccination; and that though a single booster dose of diphtheria toxoid is probably effective in adults under 45, two doses should be given to those in the older age group." 01/01/2006 - "While improved coverage of children in developing countries with diphtheria toxoid has led to progressive decreases in diphtheria; eradication is unlikely in the foreseeable future and gaps in immunity among adult population exist or are developing in many other countries. " 12/15/1989 - "On both occasions a diphtheria microneutralization assay was done for "gold standard" evidence of prior exposure to diphtheria toxoid or toxin. " 06/10/2011 - "The aim of this study was to evaluate diphtheria immunity in a sample of the Turkish population having high childhood immunization coverage, including a booster dose of diphtheria toxoid at 12-15 years of age. "
2.	Tetanus 01/01/2009 - "Frequency of medically attended adverse events following tetanus and diphtheria toxoid vaccine in adolescents and young adults: a Vaccine Safety Datalink study." 07/01/2015 - "Antigen presentation by dendritic cells is bolstered by preconditioning their injection site with the tetanus/diphtheria toxoid. " 01/01/2015 - "Safety and immunogenicity of a single intramuscular dose of a tetanus-diphtheria toxoid (Td) vaccine (BR-TD-1001) in healthy Korean adult subjects." 01/01/2015 - "In preventing deaths at four to 14 days, neonatal mortality was reduced again in the tetanus-diphtheria toxoid group (RR 0.38, 95% CI 0.27 to 0.55). " 01/01/2015 - "Neonatal mortality was reduced in the tetanus-diphtheria toxoid group (RR 0.68, 95% CI 0.56 to 0.82). "
3.	Whooping Cough (Pertussis) 02/01/1961 - "[Data on the response to and efficacy of pertussis and pertussis-diphtheria vaccine]." 12/01/1961 - "[Study on reactogenic properties and epidemiological effectiveness of the whooping cough-diphtheria vaccine in Rostov-on-Don]." 10/01/1960 - "[Study of the various causes of the body reaction to whooping cough-diphtheria vaccine in experiment]." 04/01/1960 - "[A study of the reactions caused by whooping cough-diphtheria vaccine]." 01/01/2015 - "Toxoid-diphtheria toxoid-acellular pertussis vaccination rates systemwide reached 94.9%, with an overall compliance rate of 98%. "
4.	Infection 01/01/1997 - "We have compared the serum antitoxin response to diphtheria toxoid (DTd) in normal, uninfected mice with that in mice bearing schistosome infections of different duration. " 03/13/1980 - "We reported previously that herpes simplex virus (HSV) type 1 suppressed the induction of an antibody response to diphtheria toxoid in cultures of human tonsil cells, and that this seemed to result from the infection of a small percentage of T lymphocytes. " 02/01/2000 - "The results suggest that Russian adults, who were unlikely to have acquired immunity to diphtheria through immunization or natural infection, required at least three doses of diphtheria toxoid for reliable protection against disease." 10/01/1994 - "Purified diphtheria toxoid incorporated in egg yolk and mixed with a medicinal plant seed was used to orally immunize rabbits against diphtheria infection. " 05/01/1979 - "In the groups with staphypan and in the groups with vaccinated specific vaccinia a less strong infection was observed, while a vaccinia made from salmonella typhimurium and diphtheria-toxoid showed the strongest effect. "
5.	Glioblastoma (Glioblastoma Multiforme) 06/01/2015 - "Preconditioning the immune system with a tetanus/diphtheria toxoid significantly improved the effectiveness of dendritic cell immunotherapy and extended overall survival in a small, randomized study of patients with glioblastoma. "

Related Drugs and Biologics

1.	Tetanus Toxoid (Vaccine, Tetanus)
2.	Vaccines
3.	Pertussis Vaccine
4.	Anticoagulants
5.	Hemagglutinins (Hemagglutinin)
6.	CRM197 (non-toxic variant of diphtheria toxin)
7.	Polysaccharides
8.	laminaran
9.	Antigens
10.	cholera toxoid

Related Therapies and Procedures

1.	Subcutaneous Injections
2.	Immunotherapy
3.	Home Nursing (Nursing, Home)
4.	Injections
5.	Transplantation (Transplant Recipients)