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Diphtheria Toxin

An ADP-ribosylating polypeptide produced by CORYNEBACTERIUM DIPHTHERIAE that causes the signs and symptoms of DIPHTHERIA. It can be broken into two unequal domains: the smaller, catalytic A domain is the lethal moiety and contains MONO(ADP-RIBOSE) TRANSFERASES which transfers ADP RIBOSE to PEPTIDE ELONGATION FACTOR 2 thereby inhibiting protein synthesis; and the larger B domain that is needed for entry into cells.
Also Known As:
Toxin, Corynebacterium Diphtheriae; Corynebacterium Diphtheriae Toxin
Networked: 708 relevant articles (25 outcomes, 63 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Frankel, Arthur E: 29 articles (01/2019 - 01/2002)
2. Hochberg, Abraham: 12 articles (06/2014 - 03/2005)
3. Sing, Andreas: 11 articles (09/2021 - 06/2002)
4. Vallera, Daniel A: 10 articles (01/2018 - 02/2002)
5. Frankel, A E: 9 articles (02/2009 - 04/2000)
6. Hall, Walter A: 7 articles (09/2013 - 04/2002)
7. Thorburn, Andrew: 7 articles (01/2013 - 11/2002)
8. Kreitman, Robert J: 7 articles (01/2009 - 05/2002)
9. Berger, Anja: 6 articles (09/2021 - 07/2011)
10. Sparwasser, Tim: 6 articles (01/2020 - 12/2009)

Related Diseases

1. Neoplasms (Cancer)
2. Diphtheria
3. Glioblastoma (Glioblastoma Multiforme)
4. Inflammation (Inflammations)
5. Acute Myeloid Leukemia (Acute Myelogenous Leukemia)

Related Drugs and Biologics

1. Proteins (Proteins, Gene)
2. Interleukin-2 (IL2)
3. denileukin diftitox (Ontak)
4. Immunotoxins (Immunotoxin)
5. Interleukin-2 Receptors (IL 2 Receptor)
6. Vaccines
7. Interleukin-3 (Interleukin 3)
8. Interleukins
9. Intercellular Signaling Peptides and Proteins (Growth Factors)
10. DNA (Deoxyribonucleic Acid)

Related Therapies and Procedures

1. Therapeutics
2. Drug Therapy (Chemotherapy)
3. Immunotherapy
4. Injections
5. Radiotherapy