Diphenylamine

In humans it may be irritating to mucous membranes. Methemoglobinemia has been produced experimentally. In veterinary use, it is one of active ingredients in topical agents for prevention and treatment of screwworm infestation. An indicator in tests for nitrate poisoning.

Also Known As:

Networked: 109 relevant articles (2 outcomes, 5 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Boysen, Gunnar: 2 articles (12/2021 - 01/2021)
2.	Miller, Grover Paul: 2 articles (12/2021 - 01/2021)
3.	Schleiff, Benjamin Mark: 2 articles (12/2021 - 01/2021)
4.	Schleiff, Mary Alexandra: 2 articles (12/2021 - 01/2021)
5.	Blue, Madison: 1 article (12/2021)
6.	Crosby, Samantha: 1 article (12/2021)
7.	Jonuškienė, Ilona: 1 article (07/2021)
8.	Kantminienė, Kristina: 1 article (07/2021)
9.	Mickevičius, Vytautas: 1 article (07/2021)
10.	Petrikaitė, Vilma: 1 article (07/2021)

Related Diseases

1.	Arthritis (Polyarthritis) 11/01/1954 - "WHOLE EGG YOLK INCORPORATED AS A SUPPLEMENT IN THE DIET OF BABY GUINEA PIGS AFFORDED PROTECTION AGAINST ANAPHYLACTIC ARTHRITIS AS DETERMINED: (a) by measurement of joint swelling; (b) by the rise in serum level of some substance which reacts with diphenylamine; (c) by histologic examination. " 08/01/1964 - "[DIPHENYLAMINE REACTION AND SOME OTHER BIOCHEMICAL INDICES IN THE CLINIC OF INFECTIOUS NON-SPECIFIC POLYARTHRITIS IN CHILDREN]." 05/01/1959 - "[Diphenylamine reaction in rheumatism and infectious nonspecific polyarthritis]." 01/01/1956 - "[Parallel behavior and diagnostic value of the Waaler-Rose reaction, the Paul-Bunnel reaction, the antistreptolysin titer, the diphenylamine reaction, the electrophoretic blood picture and of the erythrosedimentation rate in polyarthritis]." 08/15/1973 - "Sulfhydryl groups, copper, diphenylamine reaction and some enzymes in the serum of rats with 6-sulfanilamidoindazole arthritis."
2.	Autosomal Dominant Polycystic Kidney (ADPKD) 07/01/2000 - "Fluid secretion into the cyst lumen was blocked by diphenylamine carboxylic acid (DPC) and glibenclamide in ADPKD cells but blocked only by DPC in HRCE cells. " 07/01/1996 - "We now report that forskolin, which stimulates adenylate cyclase, increased the efflux rate constant for 36Cl in monolayers of ADPKD cells in vitro from 0.23 +/- 0.02 min-1 to 0.44 +/- 0.05 min-1 (N = 4) and that diphenylamine 2-carboxylate (DPC), which blocks chloride channels, eliminated the forskolin-stimulated chloride efflux from these cells. " 01/01/1996 - "Adenosine 3',5'-cyclic monophosphate-activated Cl- currents are present in primary cultures of ADPKD cells and have characteristics such as a linear current-voltage relation, insensitivity to 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid, sensitivity to glibenclamide and diphenylamine carboxylic acid, and an anion selectivity sequence of Br- > Cl- > I- > glutamate, all of which are identical to cystic fibrosis transmembrane conductance regulator (CFTR). "
3.	Neoplasms (Cancer) 07/01/2014 - "This case was observed in the middle dose group of a carcinogenicity study of diphenylamine, which was not carcinogenic, we determine to be this case was a spontaneous tumor. " 11/01/1995 - "These findings indicate that this styryl diphenylamine derivative has the potential to suppress the malignant phenotype of cancer cells without profound cytotoxicity in non-transformed cells." 09/01/1993 - "This finding was confirmed by analysis of the composition of the basement membrane matrix synthesized by EHS tumors grown in control and diphenylamine-treated mice. " 01/01/1978 - "The diphenylamine reaction of gastric juice in cancer and precancer conditions of stomach evaluated by adaptive linear neuron." 06/01/1961 - "A critical reevaluation of the diphenylamine test for malignancy."
4.	Necrosis 05/01/1996 - "The findings indicate that diphenylamine-induced renal papillary necrosis in the Syrian hamster is not associated with a decrease in renal papillary or outer medullary GSH nor mediated by oxidative cell injury." 12/01/1995 - "It was concluded that the endothelial cell of the ascending vasa recta is the target cell in diphenylamine-induced renal papillary necrosis in Syrian hamsters." 12/01/1995 - "The ultrastructural lesions of diphenylamine-induced renal papillary necrosis in Syrian hamsters were characterized by transmission electron microscopy. " 12/01/1995 - "Early ultrastructural lesions of diphenylamine-induced renal papillary necrosis in Syrian hamsters." 05/01/1990 - "Renal papillary necrosis in the Syrian hamster treated orally with diphenylamine is reproducible, is of short onset, and is induced in a high proportion of the hamsters (70-90%).(ABSTRACT TRUNCATED AT 250 WORDS)"
5.	Cystic Kidney Diseases (Cystic Kidney Disease) 07/01/1976 - "The results of this study show that, in the terminal stages, cellular as well as gross morphologic differences exist between polycystic and medullary cystic kidney disease and that diphenylamine-induced cystic disease more closely resembles human polycystic than medullary cystic kidney disease." 11/01/1987 - "[Cystic kidney disease induced by diphenylamine in rats]." 01/01/1978 - "Chronic intoxication with diphenylamine (DPA), which causes a cystic kidney disease in the rat and the guinea-pig, caused degeneration of the renal tubular epithelium in the chicken. " 07/01/1976 - "Comparison of human polycystic and medullary cystic kidney disease with diphenylamine-induced cystic disease." 07/01/1976 - "Most prominent among them is the renal cystic disease that is induced in rats through feeding of the antioxidant, diphenylamine, The present study examined the morphology of adult polycystic and medullary cystic kidney disease in man using scanning electron microscopy and compared them with diphenylamine-induced cystic kidney disease in rats. "

Related Drugs and Biologics

1.	Chloride Channels (Chloride Channel)
2.	Colforsin
3.	Chlorides
4.	Adenylyl Cyclases (Adenylyl Cyclase)
5.	Enzymes
6.	Antioxidants
7.	Theophylline (Theon)
8.	Oxygen (Dioxygen)
9.	Dimethyl Sulfoxide (DMSO)
10.	Azides

Related Therapies and Procedures

1.	Therapeutics
2.	Electrodes (Electrode)