Diphenoxylate

A MEPERIDINE congener used as an antidiarrheal, usually in combination with ATROPINE. At high doses, it acts like morphine. Its unesterified metabolite difenoxin has similar properties and is used similarly. It has little or no analgesic activity.

Also Known As:

Networked: 80 relevant articles (2 outcomes, 6 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Akin, Mustafa: 1 article (09/2015)
2.	Turker, Turker: 1 article (09/2015)
3.	Uysal, Bora: 1 article (09/2015)
4.	Demiral, Selcuk: 1 article (09/2015)
5.	Beyzadeoglu, Murat: 1 article (09/2015)
6.	Dincoglan, Ferrat: 1 article (09/2015)
7.	Sager, Omer: 1 article (09/2015)
8.	Gamsiz, Hakan: 1 article (09/2015)
9.	Brown, Richard: 1 article (01/2015)
10.	Sampson, Elizabeth L: 1 article (01/2015)

Related Diseases

1.	Diarrhea 05/01/1977 - "Diphenoxylate (DPO) suppressed the diarrhea in two patients not improved by DHE. " 10/01/2011 - "FA-Na (intragastric administration) had inhibit effect on normal mice and diarrhea model caused by Rheum officinale, significantly synergetic effect on gastrointestinal asynersis induced by Compound Diphenoxylate, and protective effect on mice gastric mucosal injury cause by dehydrated alcohol. " 03/01/1972 - "5. Clinical comparison of difenoxine and diphenoxylate in volunteers and in patients with chronic diarrhea. " 12/01/1961 - "Symptomatic treatment of diarrhea with diphenoxylate." 06/02/1961 - "[Diphenoxylate treatment results in 264 cases of diarrhea]."
2.	Constipation 08/01/2014 - "The mouse constipation model was induced by diphenoxylate administration. " 08/01/2013 - "Slow transit constipation (STC) rat model was induced by intragastric administration of compound diphenoxylate. " 11/01/2010 - "Two models of constipation in mice were respectively induced by fasted water for 4 days or induced by diphenoxylate. " 06/01/2009 - "In the constipated group, the rats were daily administered with diphenoxylate (8 mg/kg) to develop slow transit constipation, while the control rats were fed with water. " 10/01/2011 - "In the present study, constipation was induced in female Sprague-Dawley rats by diphenoxylate, and the prebiotics dissolved in milk were used as an intervention. "
3.	Substance Withdrawal Syndrome (Withdrawal Symptoms) 11/01/1983 - "The authors conducted a preliminary trial of a 5-day course of diphenoxylate in the treatment of out-patients with methadone withdrawal symptoms. " 11/01/1983 - "Short-course diphenoxylate hydrochloride for treatment of methadone withdrawal symptoms."
4.	Morbid Obesity 01/01/1982 - "The effect of loperamide and diphenoxylate on diarrhoea following jejuno-ileostomy for morbid obesity was investigated in 27 patients by means of a randomized fixed sample size, three-period cross-over trial. "
5.	Heroin Dependence (Heroin Abuse) 11/01/1970 - "An oral method of the withdrawal treatment of heroin dependence: a five years' study of a combination of diphenoxylate (Lomotil) and chlormethiazole (Heminevrin)."

Related Drugs and Biologics

1.	Loperamide (Imodium)
2.	Methadone (Dolophine)
3.	Atropine (Hyoscyamine)
4.	atropine sulfate-diphenoxylate hydrochloride combination (Lomotil)
5.	Octreotide (Sandostatin)
6.	Morphine (MS Contin)
7.	Codeine (Codeine Phosphate)
8.	Prebiotics
9.	Sufentanil (Sufenta)
10.	Alfentanil (Alfenta)

Related Therapies and Procedures

1.	Ileostomy
2.	Radiotherapy
3.	Drug Therapy (Chemotherapy)