Dioxins

01/01/2002 - "Even though cancer incidence may increase at high dioxin exposures, any such increase is preceded at lower exposures by a significant reduction."
01/01/2002 - "The NIOSH statistical treatment obscured the significant reduction in cancer incidence that occurs at low dioxin exposures. "
04/01/2006 - "Overall, the predictive value of TEFs would be improved by incorporating into this number the relative sensitivity of human cell responses compared to rodent responses, by determining the toxicological effects of altering the tissue distribution of dioxin-like compounds through competition for CYP-binding sites, and by understanding the mechanism of cancer causation of any dioxin and whether this mechanism is conserved in humans and at equivalent doses."
07/11/2022 - "Further studies on the health effects of dioxins in the Vietnamese population, including cancer incidence, should be conducted with improved research methods."
01/01/2020 - "Few studies on cancer incidence have been conducted since the adoption of the EU 2000/76/EC waste incineration directive which aimed to limit dioxin emission levels to less than 0.1 ng TEQ/m3 before December 31, 2005. "

11/01/2001 - "There is a significant reduction in prostate cancers in Black veterans, but not in White, as a function of increasing dioxin body burden."
12/01/2016 - "In addition, we investigated a non-dioxin-like PCB153-induced cell invasion and related markers in normal prostate stem cells (WPE-stem) and in three different prostate cancer cell lines (PC3, DU145 and 22RV1) at exposure levels relevant to humans. "
12/01/2016 - "We explored the link between non-dioxin-like PCB and grade of prostate cancer in a prospective cohort as well as in cell experiments. "
09/24/1998 - "The intended effect of this action is to relieve veterans, or their survivors, seeking benefits under the provisions of the Veterans' Dioxin and Radiation Exposure Compensation Standards Act of the burden of having to submit evidence that a veteran's prostate cancer or any other cancer may have been induced by ionizing radiation."
12/01/2016 - "Our findings both from the observational and experimental studies suggest a role of non-dioxin-like PCB153 in the development of high-grade and fatal prostate cancer."

05/01/1998 - "We found no meaningful or consistent association between dioxin exposure and prevalence of acne without or with regard to anatomical location. "
05/01/1998 - "Serum dioxin, chloracne, and acne in veterans of Operation Ranch Hand."
01/01/2015 - "We explored the expression of CYP1A1 by immunohistochemistry in the acne lesions of 16 patients living in the region of Naples, Italy, where epidemiological studies have suggested a possibly increased exposure to environmental dioxins. "
01/01/2017 - "Through these dual functions, cinnamaldehyde may be beneficial for the treatment of disorders related to oxidative stress such as dioxin intoxication, acne, and vitiligo."
01/01/2015 - "Expression of CYP1A1 in human skin is a key marker for AhR activation, and it may induce comedogenesis resulting in acne-like lesions known as chloracne/metabolising acquired dioxin-induced skin hamartomas (MADISH). "

06/01/2000 - "The exposure of these airmen to both Southeast Asia and dioxin is associated with a significant reduction of elevated systemic cancers and total skin cancers."
06/01/2000 - "Significant increases in systemic, melanoma, and presumedly total skin cancers are observed in Operation Ranch Hand veterans unexposed to dioxin. "
10/01/1977 - "The most serious research needs include the development of surveillance systems for identifying skin hazards and determining frequency of environmental skin disease; the development of new models for studying cutaneous penetration; the elucidation of the mechanisms of nonallergic inflammatory reactions (primary irritation) and of the accommodation phenomenon; the development of more sensitive models for predicting adverse responses to marginal irritants; the utilization of modern skills of immunobiology and immunochemistry to elucidate mechanisms of allergic responses; the launching of epidemiologic studies to determine the long term effects of PCBs and associated compounds such as dioxins; and the expansion of research in the mechanisms of skin cancer in relation to susceptibility, genetic and metabolic considerations, ultraviolet light, and phototoxic agents."
12/01/2010 - "Skin cancer, chloracne and hyperpigmentation have been associated with the exposure to environmental contaminants such as polychlorinated biphenyls, dioxins or polycyclic aromatic hydrocarbons. "
06/19/2012 - "The importance of cancer sites such as mesothelioma, sinonasal, lung, nasopharynx, breast, non-melanoma skin cancer, bladder, oesophagus, soft tissue sarcoma and stomach cancers are highlighted, as are carcinogens such as asbestos, mineral oils, solar radiation, silica, diesel engine exhaust, coal tars and pitches, dioxins, environmental tobacco smoke, radon, tetrachloroethylene, arsenic and strong inorganic mists, as well as occupational circumstances such as shift work and occupation as a painter or welder. "

01/01/2017 - "Through these dual functions, cinnamaldehyde may be beneficial for the treatment of disorders related to oxidative stress such as dioxin intoxication, acne, and vitiligo."