p-Dimethylaminoazobenzene (Methyl Yellow)

A reagent used mainly to induce experimental liver cancer. According to the Fourth Annual Report on Carcinogens (NTP 85-002, p. 89) published in 1985, this compound "may reasonably be anticipated to be a carcinogen." (Merck, 11th ed)

Also Known As:

Methyl Yellow; Butter Yellow; 4-Dimethylaminoazobenzene; p-Dimethylaminoazobenzene, (E)-Isomer; p-Dimethylaminoazobenzene, (Z)-Isomer; 4 Dimethylaminoazobenzene; p Dimethylaminoazobenzene; Dimethylaminoazobenzene; Benzenamine, N,N-dimethyl-4-(phenylazo)-

Networked: 194 relevant articles (2 outcomes, 16 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amines: 4871
  - Aniline Compounds: 46
    - p-Dimethylaminoazobenzene: 194

Experts

1.	Khuda-Bukhsh, Anisur Rahman: 3 articles (01/2010 - 06/2007)
2.	Karmakar, Susanta Roy: 2 articles (01/2010 - 06/2007)
3.	Bhattacharjee, Nandini: 2 articles (03/2009 - 06/2007)
4.	Pathak, Surajit: 2 articles (03/2009 - 06/2007)
5.	Akyuz, F: 1 article (07/2016)
6.	Aydin, O: 1 article (07/2016)
7.	Burukoglu, D: 1 article (07/2016)
8.	Degirmenci, I: 1 article (07/2016)
9.	Ozden, H: 1 article (07/2016)
10.	Tekin, N: 1 article (07/2016)

Related Diseases

1.	Carcinogenesis 12/01/1965 - "Studies on the binding of tritiated rho-dimethylaminoazobenzene in rat liver and the role of intranuclear binding sites in the early stages of carcinogenesis." 09/01/1954 - "[Studies on the conditions of p-dimethylaminoazobenzene carcinogenesis. " 09/01/1953 - "[Studies on the conditions of p-dimethylaminoazobenzene carcinogenesis. " 01/01/1976 - "The formula of this chemical closely resembling DAB (Butter yellow) has a certain number of special characteristics in the field of liver carcinogenesis. " 03/01/1967 - "[A comparative study of carcinogenesis of the liver of male and female rats under the effect of dimethylaminoazobenzene under various conditions of nutrition]."
2.	Body Weight (Weight, Body) 12/01/1977 - "The decrease of liver weight that occurred in shunted rats without loss of body weight produced a very significant reduction of the total capacity of liver to activate 4-dimethylaminoazobenzene while the total capacity of detoxification remained unchanged. "
3.	Neoplasms (Cancer) 02/01/1949 - "Studies on the intracellular composition of liver and liver tumor from rats fed 4-dimethylaminoazobenzene." 01/01/2010 - "Ethanolic extract of Hydrastis canadensis has been tested for its possible anti-cancer potentials against p-dimethylaminoazobenzene (p-DAB) induced hepatocarcinogenesis in mice. " 08/01/2004 - "The normal group was fed with standard forage while the rest two groups were given p-dimethylaminoazobenzene (DAB) to induce cancer. " 09/01/1971 - "Liver and lung tumors in mice exposed at birth to 4-dimethylaminoazobenzene or its 2-methyl or 3'-methyl derivatives." 11/01/1970 - "[The effect of the hormonal regime of rats on liver tumor induction by n-dimethylaminoazobenzene]."
4.	Liver Neoplasms (Liver Cancer) 07/28/1964 - "STUDIES ON THE METABOLISM OF LIVER CANCER INDUCED BY RHO-DIMETHYLAMINOAZOBENZENE. " 12/01/1956 - "[Biochemical studies in the course of the development of liver cancer by butter yellow]." 01/01/1966 - "Biliary pigments excretion in rats with cancer of the liver produced by p-dimethylaminoazobenzene (DAB)." 08/01/1964 - "EFFECT OF POLYHYDROXY-ALKYLPTERINS ON THE DEVELOPMENT OF LIVER CANCERS IN THE RAT FED WITH 4-DIMETHYLAMINOAZOBENZENE." 01/01/1960 - "[Experimental liver cancer produced with 4-dimethylaminoazobenzene. "
5.	Hepatocellular Carcinoma (Hepatoma) 09/01/1955 - "[Histochemical and biochemical studies on the development of the butter yellow-induced rat hepatoma]." 01/01/1985 - "N-13A malignant ascitic hepatoma, induced by 4-dimethylaminoazobenzene in Wistar rats, does not produce distant mestastases when transplanted in vivo. " 07/01/1975 - "As to the origin the malignoma used is a tumour induced by Methyl-Yellow and known as solid form of the Zajdela-hepatoma. " 02/01/1972 - "Cytoskeleton alterations in cells of rat hepatomas induced by 4-dimethylaminoazobenzene." 06/01/1967 - "Antigenic composition of transplanted rat hepatomas originally induced by 4-dimethylaminoazobenzene."

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4.	Enzymes
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7.	ErbB Receptors (EGF Receptor)
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Related Therapies and Procedures

1.	Injections
2.	Splenectomy
3.	Radiotherapy
4.	Immunotherapy
5.	Drug Therapy (Chemotherapy)