Dimethylallyltranstransferase (Dimethylallyltransferase)
An enzyme that, in the pathway of cholesterol biosynthesis, catalyzes the condensation of isopentenyl pyrophosphate and dimethylallylpyrophosphate to yield pyrophosphate and geranylpyrophosphate. The enzyme then catalyzes the condensation of the latter compound with another molecule of isopentenyl pyrophosphate to yield pyrophosphate and farnesylpyrophosphate. EC 2.5.1.1.
Also Known As:
Dimethylallyltransferase; Prenyltransferase; Dolichyl Phosphate Synthetase; Geranylgeranyl Pyrophosphate Synthetase; Nerylpyrophosphate Synthetase; Synthetase, Geranylpyrophosphate; Synthetase, Nerylpyrophosphate; Geranylpyrophosphate Synthetase; Dimethylallyl-diphosphate:isopentenyl-diphosphate dimethylallyl (trans) transferase
Networked: 47
relevant articles (1 outcomes,
7 trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Experts
1. | Distefano, Mark D:
4 articles
(12/2016 - 03/2013)
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2. | Weiss, Jayne S:
3 articles
(05/2018 - 05/2010)
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3. | Wang, Jun:
2 articles
(01/2019 - 11/2017)
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4. | Yan, Bingju:
2 articles
(01/2019 - 11/2017)
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5. | Kruth, Howard S:
2 articles
(01/2018 - 05/2010)
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6. | Nickerson, Michael L:
2 articles
(01/2018 - 05/2010)
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7. | Palsuledesai, Charuta C:
2 articles
(12/2016 - 01/2015)
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8. | Ochocki, Joshua D:
2 articles
(01/2014 - 03/2013)
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9. | Malkowicz, S Bruce:
2 articles
(07/2013 - 05/2010)
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10. | Cengel, Keith A:
2 articles
(09/2005 - 08/2005)
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Related Diseases
1. | Neoplasms (Cancer)
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2. | Parasitic Diseases (Parasitic Disease)
07/01/2003
- " Besides being developed as anti-cancer agents, prenyltransferase inhibitors are effective against an increasing number of parasitic diseases. " 03/01/2013
- " Prenyltransferase Inhibitors: Treating Human Ailments from Cancer to Parasitic Infections." 05/12/2022
- " Inhibitors of prenyltransferase have resulted in substantial therapeutic benefits in various diseases, such as cancer, neurological disorders, and viral and parasitic infections. " 01/16/2015
- " We also give an account of the current status of prenyltransferase inhibitors as potential therapeutics against several diseases including cancers, progeria, aging, parasitic diseases, and bacterial and viral infections. " 03/01/2013
- " In addition to cancer therapy, prenyltransferase inhibitors have begun to find important therapeutic uses in other diseases, including progeria, hepatitis C and D, parasitic infections, and other maladies. "
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3. | of Schnyder Crystalline Corneal Dystrophy
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4. | Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
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5. | Cardiomegaly (Heart Hypertrophy)
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Related Drugs and Biologics
Related Therapies and Procedures