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Dimethylallyltranstransferase (Dimethylallyltransferase)

An enzyme that, in the pathway of cholesterol biosynthesis, catalyzes the condensation of isopentenyl pyrophosphate and dimethylallylpyrophosphate to yield pyrophosphate and geranylpyrophosphate. The enzyme then catalyzes the condensation of the latter compound with another molecule of isopentenyl pyrophosphate to yield pyrophosphate and farnesylpyrophosphate. EC 2.5.1.1.
Also Known As:
Dimethylallyltransferase; Prenyltransferase; Dolichyl Phosphate Synthetase; Geranylgeranyl Pyrophosphate Synthetase; Nerylpyrophosphate Synthetase; Synthetase, Geranylpyrophosphate; Synthetase, Nerylpyrophosphate; Geranylpyrophosphate Synthetase; Dimethylallyl-diphosphate:isopentenyl-diphosphate dimethylallyl (trans) transferase
Networked: 47 relevant articles (1 outcomes, 7 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Distefano, Mark D: 4 articles (12/2016 - 03/2013)
2. Weiss, Jayne S: 3 articles (05/2018 - 05/2010)
3. Wang, Jun: 2 articles (01/2019 - 11/2017)
4. Yan, Bingju: 2 articles (01/2019 - 11/2017)
5. Kruth, Howard S: 2 articles (01/2018 - 05/2010)
6. Nickerson, Michael L: 2 articles (01/2018 - 05/2010)
7. Palsuledesai, Charuta C: 2 articles (12/2016 - 01/2015)
8. Ochocki, Joshua D: 2 articles (01/2014 - 03/2013)
9. Malkowicz, S Bruce: 2 articles (07/2013 - 05/2010)
10. Cengel, Keith A: 2 articles (09/2005 - 08/2005)

Related Diseases

1. Neoplasms (Cancer)
2. Parasitic Diseases (Parasitic Disease)
3. of Schnyder Crystalline Corneal Dystrophy
4. Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
5. Cardiomegaly (Heart Hypertrophy)

Related Drugs and Biologics

1. Proteins (Proteins, Gene)
2. Enzymes
3. Cholesterol
4. Vitamin K 2 (Vitamin K2)
5. menatetrenone
6. coenzyme Q10 (CoQ10)
7. Vitamin K
8. Vitamin K 1 (Phylloquinone)
9. Lipids
10. Antioxidants

Related Therapies and Procedures

1. Therapeutics
2. Ligation
3. Penetrating Keratoplasty
4. Radiotherapy
5. Lasers (Laser)