Diiodotyrosine

A product from the iodination of MONOIODOTYROSINE. In the biosynthesis of thyroid hormones, diiodotyrosine residues are coupled with other monoiodotyrosine or diiodotyrosine residues to form T4 or T3 thyroid hormones (THYROXINE and TRIIODOTHYRONINE).

Also Known As:

Networked: 33 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Fujikata, Akira: 1 article (01/2022)
2.	Fujita, Naoya: 1 article (01/2022)
3.	Hashimoto, Kenichi: 1 article (01/2022)
4.	Kimata, Motohiro: 1 article (01/2022)
5.	Kudo, Masahiko: 1 article (01/2022)
6.	Miyashiro, Yoshimichi: 1 article (01/2022)
7.	Ono, Yosuke: 1 article (01/2022)
8.	Oyama, Seigo: 1 article (01/2022)
9.	Sano, Azusa: 1 article (01/2022)
10.	Sato, Ikuya: 1 article (01/2022)

Related Diseases

1.	Body Weight (Weight, Body) 01/01/1976 - "[In vitro study on effect of body weight on deiodination of L-diiodotyrosine and L-thyroxine in liver and kidney of rats on standard diets]." 03/01/1965 - "[Further investigations about the gas metabolism and body weight in albino rats in a chronic experiment with administration of alloxan, p-hydroxypropiophenone, diiodotyrosine as well as methylthiouracil individually and in combinations]." 02/01/1964 - "[COMPARISON BETWEEN THE EFFECT OF THYROXIN, TRIIODOTHYRONINE AND DIIODOTYROSINE WITH AND WITHOUT ADDITIONAL METHYLTHIOURACIL ON GAS METABOLISM AND BODY WEIGHT IN THE WHITE RAT]."
2.	Neoplasms (Cancer) 03/01/1951 - "III. Alteration of thyroid, skin, blood, and tumor uptake of I131-tagged diiodotyrosine in rats by transplanted tumors." 01/01/2014 - "Hence, we propose the TCM compounds, diiodotyrosine and saussureamine C, as potential candidates as lead compounds for further study in drug development process with the TRAF6 protein against cancer. "
3.	Hyperthyroidism 04/01/1971 - "Defective deiodination of 131-I-labeled L-diiodotyrosine in a family with cases of euthyroid goiter and hyperthyroidism." 01/01/1960 - "[Study by means of radioiodine of the effects of the association of thyroxin and diiodotyrosine in hyperthyroidism]."
4.	Goiter 07/01/1957 - "Pathogenesis of a case of congenital goiter with abnormally high levels of SPI and with mono- and diiodotyrosine in the serum." 07/01/1956 - " II. The metabolism of mono- and diiodotyrosine in certain patients with familial goiter." 01/01/1975 - "Histological changes in the thyroid gland of rats in experimental goiter caused by administration of 6-methylthiouracil during 9 months, as well as changes in the structure of these glands under the effect of diurnal ingestion with food of microiodine (iodized potassium 2 mg+iodine 0.2 mg per animal), diiodotyrosine (1.25 mg per animal) and triiodthyronine (5 mcg per animal) are described. " 06/01/1971 - "Congenital goiter found in a district of Omuro, Kochi, Shikoku, Japan: familial goiter caused by possible defect of diiodotyrosine coupling to form thyroxine." 11/01/1972 - "Comparative studies of diiodotyrosine deiodinase activities in endemic goiter and congenital goiter."
5.	Thyroid Diseases (Thyroid Disease) 12/01/1975 - "Serum diiodotyrosine (DIT) was measured by radioimmunoassay in healthy subjects patients with thyroid disease and a variety of laboratorty animals. " 03/01/1968 - "[Metabolism of I-131 labeled L-diiodotyrosine in various thyroid diseases]." 04/20/1963 - "2. Metabolism of I-131-labelled L-diiodotyrosine in various thyroid diseases]."

Related Drugs and Biologics

1.	Thyroxine (Levothyroxine)
2.	TNF Receptor-Associated Factor 6 (TRAF6)
3.	Proteins (Proteins, Gene)
4.	saussureamine C
5.	Methylthiouracil
6.	Monoiodotyrosine
7.	Biomarkers (Surrogate Marker)
8.	Tyrosine (L-Tyrosine)
9.	Triiodothyronine (Liothyronine)
10.	Thyroid Hormones

Related Therapies and Procedures

1.	Therapeutics
2.	Intravenous Administration