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Cholestanol (Coprostanol)

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A cholesterol derivative found in human feces, gallstones, eggs, and other biological matter.

Also Known As:

Coprostanol; Coprosterol; 5 alpha-Cholestan-3 alpha-ol; 5 alpha-Cholestan-3 beta-ol; 5 beta-Cholestan-3 alpha-ol; 5 beta-Cholestan-3 beta-ol; Cholestan-3-ol; Cholestanol, (3alpha, 5beta)-Isomer; 5 alpha Cholestan 3 alpha ol; 5 alpha Cholestan 3 beta ol; 5 beta Cholestan 3 beta ol; Cholestan 3 ol; beta Cholestanol; beta-Cholestan-3 beta-ol, 5; beta-ol, 5 beta-Cholestan-3; Dihydrocholesterol; beta-Cholestanol; Cholestan-3-ol, (3beta,5alpha)-

Networked: 209 relevant articles (4 outcomes, 10 trials/studies)

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Bio-Agent Context: Research Results

Experts

1.	Gylling, Helena: 7 articles (10/2014 - 02/2003)
2.	Björkhem, Ingemar: 6 articles (08/2013 - 07/2002)
3.	Miettinen, Tatu A: 6 articles (08/2010 - 02/2003)
4.	Girós, M: 3 articles (09/2011 - 12/2002)
5.	Hansson, Magnus: 3 articles (09/2010 - 05/2007)
6.	Meiner, Vardiella: 3 articles (09/2010 - 04/2006)
7.	Leitersdorf, E: 3 articles (02/2001 - 06/2000)
8.	Smalley, Susan V: 2 articles (03/2015 - 05/2014)
9.	Preiss, Yudith: 2 articles (03/2015 - 05/2014)
10.	Maiz, Alberto: 2 articles (03/2015 - 05/2014)

Related Diseases

1.	Xanthomatosis (Xanthoma) 03/01/2013 - "This disease is characterized by cholestanol-containing xanthomas in tendons and brain and we could show that most of this cholestanol is formed from 7α-hydroxy-4-cholesten-3-one. " 09/01/2010 - "The driving force in the development of the xanthomas is likely to be conversion of a bile acid precursor into cholestanol. " 05/21/2010 - "Such treatment reduces the xanthomas in CTX patients in parallel with decreased cholestanol levels. " 04/01/2009 - "Early diagnosis of CTX therefore rests on measurement of serum beta-cholestanol levels, even in absence of tendon xanthomas." 04/01/2009 - "It is characterized by the presence of xanthomas in different tissues, principally brain and tendon, due to the accumulation of beta-cholestanol. "
2.	Biliary Liver Cirrhosis (Primary Biliary Cirrhosis) 04/01/1996 - "The fecal output was within the control limits, so that intestinal cholestanol production was lowered in primary biliary cirrhosis. " 04/01/1996 - "The metabolism of cholestanol in primary biliary cirrhosis." 04/01/1996 - "We conclude that an enhanced cholestanol synthesis and a cholestasis-induced decrease in biliary clearance of serum cholestanol contribute to the excessively high serum cholestanol level in primary biliary cirrhosis. " 04/01/1996 - "The concentration of serum cholestanol, a 5 alpha-saturated derivative of cholesterol, is increased in primary biliary cirrhosis proportionally to impaired liver function for unknown reasons. " 04/01/1991 - "The cholestanol/noncholesterol sterol ratios increased progressively from the controls to groups I, II and III. The serum cholestanol levels were positively related to serum bilirubin levels in all primary biliary cirrhosis patients (n = 31, r = 0.906) and to the plant sterol levels in the control group and group I, but significantly negatively in group III. The cholestanol vs. precursor sterol correlations were negative in most cases.(ABSTRACT TRUNCATED AT 250 WORDS)"
3.	Cholestasis 01/01/1996 - "Thus increased serum cholestanol is a novel finding in colonic IBD, apparently indicating the presence of subclinical cholestasis in a marked number (20-50%) of IBD patients." 04/01/1996 - "We conclude that an enhanced cholestanol synthesis and a cholestasis-induced decrease in biliary clearance of serum cholestanol contribute to the excessively high serum cholestanol level in primary biliary cirrhosis. " 06/01/1997 - "The lack of high serum cholestanol, shown earlier frequently in unoperated patients with ulcerative colitis, may indicate reversible cholestasis, a finding deserving further exploration." 05/01/1998 - "Serum cholestanol proportion, an indicator of cholestasis, was related to pruritus but was unaffected by guar gum. " 10/01/2014 - "The median (IQR) ratio of serum cholestanol to cholesterol was higher during (269 100× μg/mg cholesterol; 203-402 100× μg/mg cholesterol) than after (175 100× μg/mg cholesterol; 156-206 100× μg/mg cholesterol; P < 0.001) weaning off PN and was correlated with cholestasis (r = 0.428), portal inflammation (r = 0.511), and fibrosis (r = 0.323, P < 0.05 for all). "
4.	Mental Retardation (Idiocy) 06/30/1983 - "By early discovery and subsequent therapy it may be possible to prevent the onset of the detrimental symptoms such as mental deficiency, caused by the accumulation of cholestanol and cholesterol in CTX patients." 07/01/1991 - "His clinical symptoms showed a close association with the plasma cholestanol level; the xanthomas regressed remarkably and the mental retardation improved in association with normalization of EEG findings during treatment with CDCA alone or in combination with pravastatin. " 09/01/2002 - "Cerebrotendinous xanthomatosis (CTX) is a hereditary disorder, which is inherited as an autosomally recessive disease, causing production of cholesterol and cholestanol xanthomas and mental retardation. " 01/01/2012 - "These siblings presented with elevated cholestanol levels and typical manifestations such as tendon xanthomas, cataracts, osteopenia, mental retardation, cerebellar ataxia and peripheral neuropathy. " 12/01/1981 - "Tendinous xanthomatosis by storage of cholestanol predominantly in brain with mental retardation, and xanthomatosis with beta-sitosterol but normal mental development are two rare steatoses with abnormal cholesterol-like lipids, in which xanthomatas are visible."
5.	Seizures (Seizure) 02/01/1990 - "Oral administration of chenodeoxycholic acid improved EEG findings, serum cholestanol level and convulsive seizures. "

Related Drugs and Biologics

1.	Cholesterol
2.	sitosterol (beta-sitosterol)
3.	campesterol
4.	Sterols
5.	Chenodeoxycholic Acid (Chenix)
6.	Pravastatin (Pravachol)
7.	Phytosterols (Plant Sterols)
8.	lathosterol
9.	Desmosterol
10.	Biological Markers (Surrogate Marker)

Related Therapies and Procedures

1.	Oral Administration
2.	Liver Transplantation
3.	Total Parenteral Nutrition
4.	Blood Component Removal (Apheresis)