Dihydro-beta-Erythroidine

01/01/2004 - "Studies aimed at defining the nAChR subpopulation(s) involved in mediating ethanol-induced locomotor stimulation and accumbal dopamine overflow as well as ethanol-intake have revealed that alpha(3)beta(2) or alpha(6) (using alpha-Conotoxin MII) but not alpha(4)beta(2) (using dihydro-beta-erythroidine) or alpha(7) (using methyllycaconitine), could represent targets for developing new drugs in the treatment of alcoholism. "

02/09/2004 - "Antagonists specific for homomeric (alpha-bungarotoxin) and heteromeric (dihydro-beta-erythroidine) receptors revealed that ganglion cells express multiple functional receptor subtypes. "
05/01/1969 - "The latency of orthodromic responses indicated that ganglion cells were innervated by both B and C fibres in the hypogastric nerve.7. Orthodromic responses were blocked by tubocurarine, 5 x 10(-5) g/ml., and dihydro-beta-erythroidine, 10(-5) g/ml.8. Spontaneous, excitatory post-synaptic potentials of up to 4.8 mV in amplitude were observed. "
10/01/1978 - "2 The possibility that at least part of the excitatory pathway was interrupted as a ganglion synapse lying in one of the nodes of plexus close to the muscle was suggested by the observations that (a) the excitatory response to extrinsic nerve stimulation was reduced by the nicotinic antagonists tubocurarine (0.13 to 0.26 mM) and dihydro beta-erythroidine (0.1 to 0.14 mM). "
12/01/1971 - "1. Intracellular recordings were obtained from ganglion cells in the guinea-pig inferior mesenteric ganglion (IMG) with a segment of the distal colon attached to the lumbar colonic nerves.2. Continuous electrical activity consisting of excitatory synaptic potentials and action potentials was recorded from ganglion cells in all regions of the IMG.3. The ;spontaneous' synaptic potentials were indistinguishable from those elicited by submaximal stimulation of any of the nerve trunks connected to the IMG.4. The excitatory activity was irreversibly abolished when the lumbar colonic nerves were cut and reversibly abolished when tetrodotoxin (5 x 10(-7) g/ml.) was added to the colon side of a two-compartment organ bath.5. Addition of dihydro-beta-erythroidine (5 x 10(-6) g/ml.) to the ganglion side of the bath abolished the synaptic activity of colonic origin and the synaptic responses to stimulation of any of the nerve trunks connected to the IMG.6. Addition of dihydro-beta-erythroidine (1 x 10(-5) g/ml.) to the colon side of the bath markedly depressed the synaptic input of colonic origin but had no effect on synaptic responses produced by preganglionic nerve stimulation.7. Distension of the colonic segment and the application of 5-HT (1 x 10(-5) g/ml.) to the mucosal surface of the colon increased the frequency of synaptic input.8. The synaptic input from the colon was transiently blocked following repetitive stimulation of any of the nerve trunks connected to the IMG. "
11/01/1987 - "The effects of acetylcholine (ACh), the muscarinic antagonist scopolamine (Sco), the nicotinic antagonist dihydro-beta-erythroidine (DBE), and the acetylcholinesterase inhibitor physostigmine (Phy) on maintained and light-evoked ganglion cell discharge was examined using iontophoresis techniques. "

09/01/2003 - "The alpha4beta2*-selective antagonist dihydro-beta-erythroidine was ineffective at blocking seizures. "
05/03/2005 - "To understand how nicotinic cholinergic receptors may participate in epileptic seizures, we tested the effects of nicotine and of the competitive nicotinic antagonists dihydro-beta-erythroidine and alpha-bungarotoxin on synaptic paroxysmal depolarization shifts (PDSs) and intrinsic bursts of action potentials recorded in slices from rats presenting a cortical status epilepticus. "

05/03/2005 - "To understand how nicotinic cholinergic receptors may participate in epileptic seizures, we tested the effects of nicotine and of the competitive nicotinic antagonists dihydro-beta-erythroidine and alpha-bungarotoxin on synaptic paroxysmal depolarization shifts (PDSs) and intrinsic bursts of action potentials recorded in slices from rats presenting a cortical status epilepticus. "

02/01/1950 - "Treatment of paralysis agitans with dihydro-beta-erythroidine."