Digoxigenin

3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide. A cardenolide which is the aglycon of digoxin. Can be obtained by hydrolysis of digoxin or from Digitalis orientalis L. and Digitalis lanata Ehrh.

Also Known As:

Networked: 365 relevant articles (2 outcomes, 26 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Chae, C: 8 articles (12/2003 - 11/2000)
2.	Junker, Kerstin: 3 articles (06/2010 - 03/2002)
3.	Woo, Tsung-Ung W: 3 articles (02/2010 - 11/2007)
4.	Cho, W S: 3 articles (12/2003 - 01/2002)
5.	Choi, C: 3 articles (08/2002 - 11/2000)
6.	Bao, Yu-Zhou: 2 articles (02/2018 - 01/2017)
7.	Li, Xiao-San: 2 articles (02/2018 - 01/2017)
8.	Liu, Jie: 2 articles (02/2018 - 01/2017)
9.	Sun, Xue-Long: 2 articles (02/2018 - 01/2017)
10.	Tang, Jin-Shan: 2 articles (02/2018 - 01/2017)

Related Diseases

1.	Erythema Infectiosum (Fifth Disease) 05/01/1995 - "Digoxigenin in situ hybridization techniques were effective in demonstrating parvovirus B19 infection on fixed tissues. " 08/01/1992 - "To compare the use of biotinylated and digoxigenin labelled probes for diagnosis of human fetal parvovirus B19 infection in formalin fixed, paraffin wax embedded tissues; and to assess the cellular distribution of the virus in positive cases. " 01/01/1993 - "Of these 42 hydropic fetuses, parvovirus B19 infection was identified in 6 (14.3%) cases by the presence of typical erythroblastic nuclear inclusions in hematoxylin-eosin stained tissue and the diagnosis was confirmed by in situ hybridization using a Digoxigenin-labelled B19 DNA probe. "
2.	Residual Neoplasm 09/01/2000 - "To investigate the value of metaphase-fluorescence in situ hybridization (M-FISH) in the diagnosis of acute promyelocytic leukemia (APL) and the detection of its minimal residual disease (MRD), 10 cases of untreated acute myeloid leukemia (AML) (de novo APL 5 cases, relapsed APL 3 cases, AML-M(1) and AML-M(5) one case each) diagnosis by cell morphology at presentation and 10 cases of APL after complete remission (CR) were studied by M-FISH using a whole chromosome 17 painting probe labeled by digoxigenin and the results were compared with that of conventional cytogenetic examination and reverse transcription-polymerase chain reaction (RT-PCR). " 04/01/2000 - "Digoxigenin-end labeled oligonucleotides facilitate the detection of minimal residual disease in acute lymphoblastic leukemia."
3.	Acute Promyelocytic Leukemia 09/01/2000 - "To investigate the value of metaphase-fluorescence in situ hybridization (M-FISH) in the diagnosis of acute promyelocytic leukemia (APL) and the detection of its minimal residual disease (MRD), 10 cases of untreated acute myeloid leukemia (AML) (de novo APL 5 cases, relapsed APL 3 cases, AML-M(1) and AML-M(5) one case each) diagnosis by cell morphology at presentation and 10 cases of APL after complete remission (CR) were studied by M-FISH using a whole chromosome 17 painting probe labeled by digoxigenin and the results were compared with that of conventional cytogenetic examination and reverse transcription-polymerase chain reaction (RT-PCR). "
4.	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 09/01/2000 - "To investigate the value of metaphase-fluorescence in situ hybridization (M-FISH) in the diagnosis of acute promyelocytic leukemia (APL) and the detection of its minimal residual disease (MRD), 10 cases of untreated acute myeloid leukemia (AML) (de novo APL 5 cases, relapsed APL 3 cases, AML-M(1) and AML-M(5) one case each) diagnosis by cell morphology at presentation and 10 cases of APL after complete remission (CR) were studied by M-FISH using a whole chromosome 17 painting probe labeled by digoxigenin and the results were compared with that of conventional cytogenetic examination and reverse transcription-polymerase chain reaction (RT-PCR). "
5.	Neoplasms (Cancer) 02/10/2018 - "The SAR analysis revealed that C3-O-neoglycosides of digoxigenin exhibited stronger cytotoxicity and induction of Nur77 expression of tumor cells than C3-MeON-neoglycosides. " 12/15/1996 - "The average AR in each specimen was determined by microscopic examination of tumor tissue that was specifically stained for apoptotic bodies by a commercially available TUNEL (Tdt-mediated dUTP digoxigenin nick end labelling) assay kit. " 05/01/1997 - "Fine-needle aspirates from 51 breast carcinomas were investigated immunocytochemically for ER/PgR and by in situ hybridization technique using digoxigenin-labeled alpha-satellite probe for chromosome 6. Cases with > or = 70% two-signal nuclei were regarded as disome; the remaining tumors showed aneusomy with a variable number of signals. " 07/19/2012 - "Consistent with the induction of apoptosis by PAX5 in vitro, terminal deoxynucleotidyl transferase-mediated dUTP-digoxigenin nick end labeling (TUNEL) staining showed significantly enhanced apoptotic cells in PAX5-expressed tumors compared with the vector control tumors. " 05/01/2011 - "Amounts of apoptosis in cancer cells were analysed with immunohistochemistry and the terminal deoxyribonucleotidyl transferase-mediated dUTP-digoxigenin nick end-labelling (TUNEL) assay. "

Related Drugs and Biologics

1.	Messenger RNA (mRNA)
2.	DNA Nucleotidylexotransferase (Terminal Deoxynucleotidyl Transferase)
3.	DNA Probes
4.	DNA (Deoxyribonucleic Acid)
5.	Paraffin
6.	Complementary DNA (cDNA)
7.	Oligonucleotide Probes
8.	Enzymes
9.	Complementary RNA (cRNA)
10.	Uridine Triphosphate (UTP)

Related Therapies and Procedures

1.	Therapeutics
2.	Ligation
3.	Central Venous Catheters
4.	Mammaplasty (Breast Reconstruction)
5.	Cystectomy