Digitalis Glycosides

Glycosides from plants of the genus DIGITALIS. Some of these are useful as cardiotonic and anti-arrhythmia agents. Included also are semi-synthetic derivatives of the naturally occurring glycosides. The term has sometimes been used more broadly to include all CARDIAC GLYCOSIDES, but here is restricted to those related to Digitalis.

Also Known As:

Networked: 147 relevant articles (3 outcomes, 5 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Guyatt, G H: 3 articles (01/2004 - 01/2001)
2.	Hood, W B: 3 articles (01/2004 - 01/2001)
3.	Jaeschke, R: 3 articles (01/2004 - 01/2001)
4.	Dans, A: 2 articles (01/2001 - 01/2001)
5.	Jin, Ting-Heng: 1 article (06/2022)
6.	Li, Li: 1 article (06/2022)
7.	Liao, Liang: 1 article (06/2022)
8.	Wei, Qi-Ping: 1 article (06/2022)
9.	Xia, Yan-Ting: 1 article (06/2022)
10.	Xiao, Yan-Ping: 1 article (06/2022)

Related Diseases

1.	Heart Failure 03/01/1991 - "Despite 200 years of use, the ability of digitalis glycosides to improve exercise capacity in patients with congestive heart failure remains controversial, partly because of imprecise end points and suboptimal study design. " 10/01/1989 - "The future place of digitalis glycosides in the treatment of cardiac failure will depend on the results of studies comparing them with new positive inotropic drugs. " 09/01/2015 - "Since the end of the XVIII century, digitalis glycosides were employed in heart failure. " 04/28/2014 - "Digitalis glycosides have been in clinical use for the treatment of heart failure (HF) for longer than 200 years. " 05/01/2013 - "Digitalis glycosides are known to improve the hemodynamic and neurohormonal perturbations that contribute to heart failure (HF)-induced renal dysfunction (RD). "
2.	Atrial Fibrillation 12/22/2020 - "Digitalis Glycosides for Heart Rate Control in Atrial Fibrillation." 10/01/2019 - "Digitalis glycosides are employed for rate control of atrial fibrillation. " 01/01/1994 - "[The use of digitalis glycosides in atrial fibrillation]." 09/01/1991 - "Digitalis glycosides have been shown in humans to improve various parameters of CHF in a subset of patients with either atrial fibrillation or third heart sounds. " 10/01/1989 - "Digitalis glycosides have an antiarrhythmic effect in atrial fibrillation, as defibrillatory drugs. "
3.	Asthenopia (Eyestrain) 12/01/2010 - "To study the clinical efficacy and safety of the Esculin and Digitalis glycosides Eye Drops used in the patients of ametropic asthenopia. " 12/01/2010 - "[The clinical efficacy and safety study of Esculin and Digitalis glycosides Eye Drops in treating ametropic asthenopia]." 12/01/2010 - "The experiment was conducted asthenopia patients who used the Esculin and Digitalis glycosides Eye Drops for 4 weeks continuously. " 12/01/2010 - "Esculin and Digitalis glycosides Eye Drops is effective and safety for use in the patients of ametropia asthenopia." 06/12/2022 - "Wei's triple nine needling combined with esculin and digitalis glycosides eye drops could improve the visual fatigue and eye regulation ability in patients with presbyopia complicated with visual fatigue of liver depression and spleen deficiency, and the effect is better than esculin and digitalis glycosides eye drops alone. "
4.	Hypoxia (Hypoxemia) 05/26/1976 - "Effects of hypoxia and digitalis glycosides on myocardial stiffness." 09/01/1991 - "The purpose of this study was to determine whether digitalis glycosides alter the effect of anoxia and reoxygenation on the cardiac myocytes and whether it could be modified by inhibition with amiloride. " 09/01/1991 - "These findings indicate the potentially deleterious effects of digitalis glycosides in myocardial anoxia and reoxygenation and the ability of amiloride to oppose these adverse effects." 09/01/1991 - "Digitalis glycosides accentuate the depressant effect of anoxia and reoxygenation on the cardiac myocyte: antagonism by amiloride."
5.	Cardiac Arrhythmias (Arrythmia) 01/01/1980 - "[Digitalis glycosides and arrhythmia]." 04/20/1979 - "Available evidence suggests that the propensity of digitalis glycosides to produce cardiac arrhythmias is due in part to their neuroexictatory effects. " 01/01/1977 - "5 It was concluded that sampling the large areas of neural tissue above could provide no evidence for local accumulation of digitalis glycosides that might account for a central nervous system origin of digitalis-induced cardiac arrhythmias." 06/01/1988 - "Clinical observations suggest that a prevalent condition for the occurrence of cardiac arrhythmias is the synergistic interaction of several risk factors including digitalis glycosides, myocardial ischemia and psychological stress. " 01/01/1978 - "This applies to the treatment of latent or manifest heart failure with digitalis glycosides, the treatment of coronary insufficiency with suitably active medicaments, and the administration of antiarrhythmics to patients with cardiac arrhythmias, who could be particularly endangered under certain circumstances. "

Related Drugs and Biologics

1.	Diuretics
2.	Anti-Arrhythmia Agents
3.	Ophthalmic Solutions (Eye Drops)
4.	Esculin (Aesculin)
5.	Norepinephrine (Noradrenaline)
6.	Amiloride (Midamor)
7.	Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)
8.	Digoxin (Digitek)
9.	Vasodilator Agents (Vasodilators)
10.	Sodium Potassium Chloride Symporter Inhibitors (Loop Diuretics)

Related Therapies and Procedures

1.	Therapeutics
2.	Intravenous Administration
3.	Oral Administration
4.	Percutaneous Collagen Induction