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Diflunisal (Dolobid)

A salicylate derivative and anti-inflammatory analgesic with actions and side effects similar to those of ASPIRIN.

Also Known As:

Dolobid; Apo-Diflunisal; Apotex Brand of Diflunisal; Cahill May Roberts Brand of Diflunisal; Dolobis; Dolocid; Frosst SA Brand of Diflunisal; MK-647; Merck Brand of Diflunisal; Merck Sharp & Dohme Brand of Diflunisal; Novo-Diflunisal; Novopharm Brand of Diflunisal; Nu-Diflunisal; Nu-Pharm Brand of Diflunisal; Diflunisal Novopharm Brand; MK 647; MK647; Nu Pharm Brand of Diflunisal; (1,1'-Biphenyl)-3-carboxylic acid, 2',4'-difluoro-4-hydroxy-

Networked: 232 relevant articles (46 outcomes, 67 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Sekijima, Yoshiki: 11 articles (09/2015 - 05/2004)
2.	Kelly, Jeffery W: 6 articles (12/2013 - 05/2004)
3.	Ikeda, Shu-ichi: 5 articles (01/2015 - 12/2006)
4.	Suhr, Ole B: 3 articles (12/2015 - 06/2012)
5.	Ando, Yukio: 3 articles (12/2015 - 06/2012)
6.	Tojo, Kana: 2 articles (01/2015 - 12/2006)
7.	Skinner, Martha: 2 articles (12/2013 - 06/2012)
8.	Yamashita, Taro: 2 articles (12/2013 - 06/2012)
9.	Merlini, Giampaolo: 2 articles (12/2013 - 06/2012)
10.	Bisbee, Alice B: 2 articles (12/2013 - 06/2012)

Related Diseases

1.	Pain (Aches) 06/01/1990 - "The outcome showed that compared to the on-demand usage, the posttreatment prophylactic administration of diflunisal resulted in a statistically significant reduction in the number of episodes of endodontic posttreatment pain that required analgesic intervention. " 08/01/1987 - "At 1 1/2-2 h after post-operative administration, patients receiving the combination post-operatively reported significantly greater decreases in pain severity than those receiving diflunisal. " 06/01/1985 - "Pain relief was significantly greater with both doses of diflunisal than with placebo. " 01/01/1983 - "Diflunisal produced a significantly greater improvement in evening pain (p = 0.03), morning stiffness (p = 0.01) and the average total grip strength (p = 0.05). " 05/01/1989 - "Treatment with diflunisal 30 minutes after completion of surgery proved to be just as effective in suppressing postsurgical pain as presurgical administration. "
2.	Postoperative Pain 06/01/1988 - "Therapeutic doses of diflunisal, given presurgically, are significantly more effective than placebo in limiting postoperative pain associated with periodontal surgery." 02/01/1977 - "2. Diflunisal was found to be effective in relieving postoperative pain in 75-85% of patients. " 02/01/1991 - "This study evaluated the efficacy of diflunisal as an analgesic to reduce postoperative pain when administered immediately following periodontal surgery. " 01/01/2010 - "Randomised, double blind, placebo-controlled trials of single dose orally administered diflunisal in adults with moderate to severe acute postoperative pain. " 01/01/1979 - "An open study was carried out in 196 consecutive patients who had undergone orthopaedic (103) or gynaecological (93) surgical procedures to assess the effectiveness and tolerability of a single dose of 500 mg diflunisal in the relief of postoperative pain. "
3.	Renal Insufficiency (Renal Failure) 09/01/1986 - "To provide insight into the reported reduction in the plasma clearance of diflunisal in human renal failure, this investigation evaluated several possible mechanisms for this effect in experimental renal failure. " 09/01/1986 - "Possible mechanisms for reduced plasma clearance of diflunisal in rat experimental renal failure." 08/01/1980 - "Decreased clearance of diflunisal in renal insufficiency--an alternative explanation." 12/01/1979 - "Decreased body clearance of diflunisal in renal insufficiency--an alternative explanation." 05/01/1991 - "Although earlier studies in renal failure patients have almost certainly underestimated diflunisal clearance (by overestimation of plasma diflunisal concentrations through unrecognized acidic hydrolysis of diflunisal sulphate during analysis), the present results suggest that the reported decrease in clearance was not attributable only to this analytical artifact."
4.	Osteoarthritis 06/01/1986 - "The efficacy of diflunisal in osteoarthritis of the knee: an extended study." 06/01/1985 - "The efficacy of diflunisal in osteoarthritis of the knee. " 01/01/1986 - "In this study, diflunisal was found to be an effective and well tolerated drug for use in the management of osteoarthritis." 03/01/1982 - "Diflunisal (Fluniget, MK-647) was tested in an open clinical study with regard to its analgesic effect and its improvement of function in 30 patients suffering from osteoarthrosis of the hip and the knee. " 01/01/1978 - "Two trials of diflunisal in osteoarthritis."
5.	Rheumatoid Arthritis 01/01/1985 - "A 4-week, double-blind, controlled multi-centre study was carried out in 235 patients with active rheumatoid arthritis to compare the efficacy and tolerance of 500 mg or 1000 mg diflunisal per day administered once daily, in the evening, or in divided, twice daily dosage. " 05/01/1984 - "Long-term studies using a higher-dose regimen are suggested to further define the efficacy and tolerability of diflunisal in the treatment of patients with rheumatoid arthritis." 02/15/1981 - "The results of the study showed Diflunisal in an average dosage of 500 to 1000 mg per day to be a useful drug in the treatment of rheumatoid arthritis not least due to the negligible side effects." 01/01/1989 - "In addition, the multiple-dose plasma kinetics of diflunisal was assessed in healthy volunteers and in patients with rheumatoid arthritis. " 01/01/1986 - "Urinary excretion patterns in volunteers and rheumatoid arthritis patients revealed that sulfate conjugation of diflunisal is a minor metabolic pathway after single 500-mg dose administration (less than 10% of the dose), whereas it becomes a major pathway (21.3-44.3% of the dose) following multiple doses (500 mg b.i.d.). "

Related Drugs and Biologics

1.	Aspirin (Acetylsalicylic Acid)
2.	Naproxen (Naprosyn)
3.	Acetaminophen (Paracetamol)
4.	Codeine (Codeine Phosphate)
5.	Diclofenac (SR 38)
6.	Dextropropoxyphene (Darvon)
7.	Ketorolac
8.	Ibuprofen (Motrin)
9.	Indomethacin (Indometacin)
10.	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)

Related Therapies and Procedures

1.	Episiotomy
2.	Oral Surgery (Maxillofacial Surgery)
3.	Analgesia
4.	Musculoskeletal Manipulations (Manipulative Therapy)
5.	Aftercare (After-Treatment)