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Diffuse Idiopathic Skeletal Hyperostosis

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A disease of elderly men characterized by large osteophytes that bridge vertebrae and ossification of ligaments and tendon insertions.

Also Known As:

Hyperostosis, Diffuse Idiopathic Skeletal; Ankylosing Hyperostoses, Vertebral; Ankylosing Hyperostosis, Vertebral; Disease, Forestier; Hyperostoses, Vertebral Ankylosing; Hyperostosis, Vertebral Ankylosing; Vertebral Ankylosing Hyperostoses; Forestier Disease; Vertebral Ankylosing Hyperostosis

Networked: 117 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Disease Context: Research Results

Musculoskeletal Diseases: 179
- Bone Diseases: 3566
  - Hyperostosis: 306
    - Diffuse Idiopathic Skeletal Hyperostosis: 117
      - Forestier's disease: 102
      - Beardwell syndrome
  - Spinal Diseases: 190
    - Spinal Osteophytosis: 4
      - Diffuse Idiopathic Skeletal Hyperostosis: 117
        Forestier's disease: 102
        Beardwell syndrome

Related Diseases

1.	Hyperostosis
2.	Obesity
3.	Deglutition Disorders (Dysphagia)
4.	Osteophyte
5.	Osteoarthritis

Experts

1.	Malemud, Charles J: 5 articles (02/2006 - 04/2002)
2.	Denko, Charles W: 5 articles (02/2006 - 04/2002)
3.	Masiero, Stefano: 2 articles (03/2010 - 02/2006)
4.	Tsukahara, So: 2 articles (01/2007 - 10/2005)
5.	Atzeni, Fabiola: 2 articles (05/2006 - 05/2004)
6.	Sarzi-Puttini, Piercarlo: 2 articles (05/2006 - 05/2004)
7.	Boja, Betty: 2 articles (01/2003 - 04/2002)
8.	Karkos, Petros D: 1 article (05/2015)
9.	Sasaki, Shunji: 1 article (05/2015)
10.	Matsumoto, Takuji: 1 article (05/2015)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Diffuse Idiopathic Skeletal Hyperostosis:

1.	Teriparatide (Parathar)FDA Link 05/01/2015 - "Effective treatment of delayed union of a lumbar vertebral fracture with daily administration of teriparatide in a patient with diffuse idiopathic skeletal hyperostosis."
2.	Insulin (Novolin)FDA Link 10/01/2009 - "Impaired insulin secretion and uptake in patients with diffuse idiopathic skeletal hyperostosis." 09/01/1985 - "Insulin and new bone formation in diffuse idiopathic skeletal hyperostosis." 05/01/1996 - "Metabolic factors are likely to play a role in the pathogenesis of diffuse idiopathic skeletal hyperostosis, and recent studies have demonstrated elevated insulin and growth hormone but normal insulin-like growth factor-1 levels in these patients. " 02/01/1991 - "In patients with diffuse idiopathic skeletal hyperostosis (DISH), serum levels of insulin and GH were elevated, but IGF-1 levels were normal. " 11/01/1981 - "The insulin response after a glucose challenge was studied in 11 male patients with diffuse idiopathic skeletal hyperostosis (DISH) and in 8 age, sex and weight matched controls. "
3.	Forestier's diseaseIBA 05/01/2014 - "Diffuse idiopathic skeletal hyperostosis (DISH), also known as Forestier's disease, is an ossifying disease of unknown etiology affecting mainly elderly men. " 01/01/2014 - "Forestier's disease, also known as diffuse idiopathic skeletal hyperostosis (DISH), is a pathology of vertebral bodies characterised by exuberant osteophytis formation. " 04/07/2010 - "Diffuse idiopathic skeletal hyperostosis or Forestier's disease is an idiopathic disease characterized by the ossification of the anterior longitudinal ligament of vertebra and some of the extraspinal ligaments. " 10/01/2008 - "Diffuse idiopathic skeletal hyperostosis (DISH) or Forestier's disease is a common disorder of unknown etiology that is characterized by ossification of the anterior longitudinal ligament of the spine and various extra-spinal ligaments. " 01/01/2008 - "Forestier's disease, also known as diffuse idiopathic skeletal hyperostosis (DISH), is an idiopathic rheumatological abnormality in which exuberant ossification occurs along throughout the body, but most notably the anterior longitudinal ligament of the spine. "
4.	Growth Hormone (Somatotropin)IBA 01/01/1992 - "Growth hormone secretion in diffuse idiopathic skeletal hyperostosis." 01/01/2003 - "Standard radioimmunoassay was employed to quantify matched basal intra-erythrocyte growth hormone (GH) and serum GH levels from patients with osteoarthritis, diffuse idiopathic skeletal hyperostosis (DISH), gout, and Sjögren's syndrome and in a group of normal volunteers (control group). " 10/20/2004 - "These results in systemic lupus erythematosus differ from those previously reported in other musculoskeletal disorders such as rheumatoid arthritis, osteoarthritis, fibromyalgia, diffuse idiopathic skeletal hyperostosis and hypermobility syndrome where significantly higher serum growth hormone levels were found. " 05/01/1996 - "Metabolic factors are likely to play a role in the pathogenesis of diffuse idiopathic skeletal hyperostosis, and recent studies have demonstrated elevated insulin and growth hormone but normal insulin-like growth factor-1 levels in these patients. " 04/01/2002 - "Growth hormone and insulin-like growth factor-I in symptomatic and asymptomatic patients with diffuse idiopathic skeletal hyperostosis (DISH)."
5.	Glucose (Dextrose)FDA LinkGeneric 11/01/1981 - "Marked hyperinsulinemia after glucose challenge in patients with diffuse idiopathic skeletal hyperostosis." 12/01/2000 - "Diffuse idiopathic skeletal hyperostosis in diabetes mellitus, impaired glucose tolerance and obesity." 11/01/1981 - "The insulin response after a glucose challenge was studied in 11 male patients with diffuse idiopathic skeletal hyperostosis (DISH) and in 8 age, sex and weight matched controls. " 06/01/2012 - "Clinically, the presence of diffuse idiopathic skeletal hyperostosis (DISH) has been linked to a disturbance of glucose and insulin metabolism, hypertension, dyslipidemia and obesity associated with a rich diet. " 01/01/1992 - "Serum insulin and C-peptide response to an oral glucose tolerance test (OGTT) and serum growth hormone (GH) response to an intravenous insulin tolerance test (IVITT) were investigated in six non-obese patients, with normal glucose tolerance, affected by diffuse idiopathic skeletal hyperostosis (DISH). "
6.	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/01/2014 - "We aimed to review the literature linking metabolic factors to Diffuse Idiopathic Skeletal Hyperostosis (DISH), in order to assess associations between growth factors and DISH. " 09/01/1994 - "To investigate growth factors influencing bone and cartilage in patients with diffuse idiopathic skeletal hyperostosis (DISH). " 01/01/2000 - "We examined the correlation between the activation of nuclear factor kappaB (NFkappaB), stimulated by environmental factors involving cytokines and growth factors in ligament cells, and the onset of ossification of the spinal ligaments (OSL) or diffuse idiopathic skeletal hyperostosis (DISH). " 01/01/2014 - "We identified studies in our personal database and PubMed using the following keywords in various combinations: "diffuse idiopathic skeletal hyperostosis", "ankylosing hyperostosis", "Forestier's disease", "diabetes", "insulin", "obesity", "metabolic", "growth factors", "adipokines", "glucose tolerance" and "chondrocytes". "
7.	AdipokinesIBA 01/01/2014 - "We identified studies in our personal database and PubMed using the following keywords in various combinations: "diffuse idiopathic skeletal hyperostosis", "ankylosing hyperostosis", "Forestier's disease", "diabetes", "insulin", "obesity", "metabolic", "growth factors", "adipokines", "glucose tolerance" and "chondrocytes". "
8.	Isotretinoin (Accutane)FDA LinkGeneric 01/01/2015 - "Diffuse idiopathic skeletal hyperostosis and isotretinoin in cystic acne." 01/01/2014 - "The development of skeletal hyperostosis, predominantly of the spine, has been reported in association with isotretinoin use and has a radiographic picture similar to diffuse idiopathic skeletal hyperostosis. " 10/01/2014 - "Avascular necrosis of the hip and diffuse idiopathic skeletal hyperostosis during long-term isotretinoin treatment of epidermolytic ichthyosis due to a novel deletion mutation in KRT10." 11/06/1986 - "Isotretinoin, a synthetic retinoid that has been prescribed for over 500,000 patients with cystic acne, has been associated with both spinal hyperostosis and a disorder similar to diffuse idiopathic skeletal hyperostosis. " 11/01/2006 - "There have been reports of diffuse idiopathic skeletal hyperostosis (DISH) syndrome, calcification of ligaments, and osteoporosis, as well as premature fusion of epiphyses and modeling abnormalities of long bones, occurring in patients on chronic high-dose isotretinoin, etretinate, and acitretin therapy. "
9.	Vitamin A (Retinol)FDA LinkGeneric 02/22/1986 - "[Role of vitamin A in vertebral ankylosing hyperostosis]." 05/01/1998 - "High levels of serum retinol and retinol binding protein (RBP) have been observed in patients with diffuse idiopathic skeletal hyperostosis (DISH). " 07/01/1995 - "We describe a 52-year-old man who presented with diffuse idiopathic skeletal hyperostosis, ossification of the posterior longitudinal ligament, and abnormal levels of retinol and retinol binding protein (RBP). " 07/01/1995 - "Ossification of the posterior longitudinal ligament, diffuse, idiopathic skeletal hyperostosis, abnormal retinol and retinol binding protein: a familial observation." 01/01/1995 - "The cause of OPLL remains unknown: genetic factors, vitamin A, association with diffuse idiopathic skeletal hyperostosis, calcium metabolism abnormalities are discussed. "
10.	Insulin-Like Growth Factor I (IGF-1)IBA 08/01/2005 - "Elevated serum GH levels in various rheumatic diseases were not coupled to changes in serum IGF-1 in diffuse idiopathic skeletal hyperostosis, RA, and fibromyalgia. " 04/01/2002 - "Growth hormone and insulin-like growth factor-I in symptomatic and asymptomatic patients with diffuse idiopathic skeletal hyperostosis (DISH)." 02/01/1991 - "In patients with diffuse idiopathic skeletal hyperostosis (DISH), serum levels of insulin and GH were elevated, but IGF-1 levels were normal. " 04/01/2002 - "Basal serum growth hormone (GH) and insulin-like growth factor-I (IGF-I) concentration was measured by radioimmunoassay in patients with diffuse idiopathic skeletal hyperostosis (DISH) with muscle and joint pain and stiffness (symptomatic group) and in DISH patients without these constitutional clinical symptoms (asymptomatic group), but with persistent radiographic evidence of DISH. " 09/01/1994 - "Growth promoting peptides in osteoarthritis and diffuse idiopathic skeletal hyperostosis--insulin, insulin-like growth factor-I, growth hormone."

Therapies and Procedures

1.	Arthroplasty 08/15/2014 - "After standard hip arthroplasty, an 82-year-old patient with previously undiagnosed diffuse idiopathic skeletal hyperostosis of the cervical spine experienced life-threatening side effects after use of a supraglottic airway device (i-gel). " 09/01/2007 - "Diffuse idiopathic skeletal hyperostosis as a cause of acute respiratory distress in early postoperative period of total knee arthroplasty." 04/01/1995 - "We investigated the risk of heterotopic ossification (HO) after total hip arthroplasty in 67 patients, 16 of whom had diffuse idiopathic skeletal hyperostosis (DISH). " 04/01/1995 - "Antivitamin K prevents heterotopic ossification after hip arthroplasty in diffuse idiopathic skeletal hyperostosis. " 06/01/1988 - "Ectopic ossification following total hip arthroplasty: is diffuse idiopathic skeletal hyperostosis a risk factor?"
2.	Hip Replacement Arthroplasty (Total Hip Replacement) 06/01/2012 - "Thoracic vertebral body fracture after total hip replacement in diffuse idiopathic skeletal hyperostosis." 01/01/1983 - "It is concluded that the existence of diffuse idiopathic skeletal hyperostosis is not a contra-indication to total hip replacement provided that the main complaint of the patient is of pain." 06/01/2012 - "This article describes the critical clinical sequelae of a patient with diffuse idiopathic skeletal hyperostosis who sustained an acute iatrogenic thoracic vertebral body fracture with subsequent spinal cord injury after a total hip replacement, with a final lethal course.A 57-year-old woman was referred to the authors' institution after undergoing a total hip replacement in the supine position for secondary osteoarthritis. "
3.	Musculoskeletal Manipulations (Manipulative Therapy) 12/01/2012 - "The findings in this case study showed that Activator-assisted spinal manipulative therapy had positive subjective and objective results for LBP and ambulation in a geriatric veteran with degenerative disk disease and diffuse idiopathic skeletal hyperostosis."
4.	Tracheostomy 05/01/2015 - "Diffuse idiopathic skeletal hyperostosis as an acute airway presentation requiring urgent tracheostomy."
5.	Spinal Fusion (Spondylosyndesis) 08/15/2003 - "A rare case of spontaneous symptomatic pseudoarthrosis at the T11-T12 intervertebral space with diffuse idiopathic skeletal hyperostosis was treated successfully by spinal fusion."