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Dicyclohexylcarbodiimide (DCCD)

A carbodiimide that is used as a chemical intermediate and coupling agent in peptide synthesis. (From Hawley's Condensed Chemical Dictionary, 12th ed)
Also Known As:
DCCD; Cyclohexanamine, N,N'-methanetetraylbis-
Networked: 45 relevant articles (1 outcomes, 6 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Ulmer, Anja: 3 articles (01/2021 - 02/2014)
2. Breuninger, Helmut: 2 articles (01/2018 - 02/2014)
3. Dietz, Klaus: 2 articles (01/2018 - 02/2014)
4. Fierlbeck, Gerhard: 2 articles (01/2018 - 02/2014)
5. Garbe, Claus: 2 articles (01/2018 - 02/2014)
6. Klein, Christoph A: 2 articles (01/2018 - 02/2014)
7. Röcken, Martin: 2 articles (01/2018 - 02/2014)
8. Fragoso, Jesus: 1 article (01/2022)
9. Nahm, William J: 1 article (01/2022)
10. Prasad, Jaideep: 1 article (01/2022)

Related Diseases

1. Infections
2. Dehydration (Water Stress)
3. Hypoxia (Hypoxemia)
4. Hepatocellular Carcinoma (Hepatoma)
5. Alzheimer Disease (Alzheimer's Disease)
11/01/1998 - "NACP, the precursor protein of the non-amyloid beta/A4 protein (Abeta) component of Alzheimer's disease (AD) amyloid, also known as alpha-synuclein was shown to undergo self-oligomerization only in the presence of a modified Abeta fragment (residues 25 35) by using a relatively hydrophobic coupling reagent, dicyclohexylcarbodiimide (DCCD). "
01/01/2021 - "Overall, our study revealed a pivotal role of NRBF2 as a new RAB7 effector in modulating autophagosome maturation, providing insight into the molecular mechanism of NRBF2-PtdIns3K in regulating RAB7 activity for macroautophagy/autophagy maturation and Alzheimer disease-associated protein degradation..Abbreviations: 3xTg AD, triple transgenic mouse for Alzheimer disease; Aβ, amyloid beta peptide; Aβ1-40, amyloid beta peptide 1-40; Aβ1-42, amyloid beta peptide 1-42; AD, Alzheimer disease; APP, amyloid beta precursor protein; APP-CTFs, APP C-terminal fragments; ATG, autophagy related; ATG5, autophagy related 5; ATG7, autophagy related 7; ATG14, autophagy related 14; CCD, coiled-coil domain; CCZ1, CCZ1 homolog, vacuolar protein trafficking and biogenesis associated; CHX, cycloheximide; CQ, chloroquine; DAPI, 4',6-diamidino-2-phenylindole; dCCD, delete CCD; dMIT, delete MIT; FYCO1, FYVE and coiled-coil domain autophagy adaptor 1; FYVE, Fab1, YGL023, Vps27, and EEA1; GAP, GTPase-activating protein; GDP, guanine diphosphate; GEF, guanine nucleotide exchange factor; GTP, guanine triphosphate; GTPase, guanosine triphosphatase; HOPS, homotypic fusion and vacuole protein sorting; ILVs, endosomal intralumenal vesicles; KD, knockdown; KO, knockout; LAMP1, lysosomal associated membrane protein 1; MAP1LC3/LC3, microtubule associated protein 1 light chain 3; MLVs, multilamellar vesicles; MON1A, MON1 homolog A, secretory trafficking associated; NRBF2, nuclear receptor binding factor 2; PtdIns3K, class III phosphatidylinositol 3-kinase; PtdIns3P, phosphatidylinositol-3-phosphate; RILP, Rab interacting lysosomal protein; SNARE, soluble N-ethylmaleimide-sensitive factor attachment protein receptor; SQSTM1/p62, sequestosome 1; UVRAG, UV radiation resistance associated; VPS, vacuolar protein sorting; WT, wild type."

Related Drugs and Biologics

1. Adenosine Triphosphatases (ATPase)
2. Carbonyl Cyanide m-Chlorophenyl Hydrazone (CCCP)
3. Protons (Proton)
4. Indicators and Reagents (Reagents)
5. Amyloid beta-Peptides
6. Proline (L-Proline)
7. Phosphates (Orthophosphate)
8. Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)
9. Lysosomal-Associated Membrane Protein 1
10. Voltage-Dependent Anion Channels