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Dichlorvos

An organophosphorus insecticide that inhibits acetylcholinesterase.

Also Known As:

Dichlofos; Dichlorophos; Dimethyl Dichlorovinyl Phosphate; Divipan; Novotox; Phosphoric acid 2,2-dichloroethenyl dimethyl ester; Phosphoric acid 2,2 dichloroethenyl dimethyl ester; DDVP; Phosphoric acid, 2,2-dichloroethenyl dimethyl ester

Networked: 209 relevant articles (15 outcomes, 34 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 58
- Organophosphorus Compounds: 163
  - Dichlorvos: 209

Experts

1.	Gill, Kiran Dip: 10 articles (02/2014 - 02/2002)
2.	Gaspari, Romolo J: 7 articles (12/2013 - 12/2002)
3.	Bird, Steven B: 6 articles (03/2014 - 12/2002)
4.	Binukumar, B K: 5 articles (12/2011 - 01/2010)
5.	Bal, Amanjit: 4 articles (12/2011 - 01/2010)
6.	Raheja, Geetu: 4 articles (02/2009 - 02/2002)
7.	Dickson, Eric W: 4 articles (04/2006 - 12/2002)
8.	Kirichuk, V F: 4 articles (08/2003 - 05/2001)
9.	Germanchuk, V G: 4 articles (08/2003 - 05/2001)
10.	Sunkaria, Aditya: 3 articles (02/2014 - 04/2010)

Related Diseases

1.	Poisoning 06/23/2015 - "In a mouse model of organophosphate poisoning, the nanoparticles were shown to improve the AChE activity in the blood and markedly improved the survival of dichlorvos-challenged mice. " 01/01/2004 - "The rapid fall in blood DDVP level and the dramatic clinical response suggest that HP is effective in the treatment of acute severe DDVP poisoning." 04/01/2005 - "CPA has therapeutic efficacy against acute dichlorvos poisoning, which is probably through the decrease in ACh concentration." 10/01/2012 - "In this study, a pulse-induced contour cardiac output monitor was used to evaluate the respiratory status in a pig model of acute dichlorvos poisoning. " 01/01/2010 - "The aim of the present study was to explore the effect of oxidative stress on hemorheological changes during dichlorvos poisoning in rabbits. "
2.	Malaria 01/01/1963 - "Chemical, biological, toxicological and epidemiological data obtained during the first nine months indicate that the method produced dichlorvos vapours in a concentration effective against mosquitos for 3 to 5 months per treatment, that the occupants of the treated dwellings showed no detectable effects from the insecticidal vapours, and that the malaria rates were reduced by 38%-55% among the population of the treated village as compared with a nearby untreated control village." 09/01/1966 - "Studies with dichlorvos residual fumigant as a malaria eradication technique in Haiti. " 09/01/1966 - "Studies with dichlorvos residual fumigant as a malaria eradication technique in Haiti. " 09/01/1966 - "Studies with dichlorvos residual fumigant as a malaria eradication technique in Haiti. " 01/01/1965 - "The objective of the trial was to see if dichlorvos would interrupt the transmission of malaria under local conditions when used at a dosage of one dispenser per 15 m(3) of living space. "
3.	Body Weight (Weight, Body) 02/01/2007 - "Chronic dichlorvos exposure (6 mg/kg b.wt/day) for a period of 8 weeks resulted in significant reduction in body weight gain of the male Wistar rats. " 02/01/2013 - "A total of 120 male Wistar rats were treated with 0, 2.4, 7.2, and 21.6 mg/kg of body weight/day DDVP continuously for 24 weeks by drinking water. " 10/30/2011 - "Three different doses (2.4, 7.2, and 21.6 mg/kg body weight/day) of DDVP were administered to rats through their drinking water over 24 weeks. " 05/14/2010 - "Rats were grouped into four: A, B, C and D where A (the control) received orally 1 ml of distilled water; B, C and D (test groups) received orally 2.5, 5 and 10mg/kg body weight of DDVP respectively for 28 days. " 02/27/2009 - "Dichlorvos, at a dose of 1.0 and 6.0 mg/kg body weight (b.wt.) for 12 weeks, showed impairment in neurobehavioral indices viz. "
4.	Seizures (Seizure) 01/01/2013 - "The goal of this study was to evaluate the effect of dizoxide on Dichlorvos-induced seizures in mice. " 01/01/2013 - "After Dichlorvos injection, latency of clones, severity of seizure, and finally death as the fate were investigated. " 01/01/2013 - "Reports have shown that Dichlorvos generate seizure effects in various animals. " 04/01/2003 - "Both DDVP and MET induced dose-dependent seizures and lethality in mice. " 02/01/2015 - "All of these results suggested that the toxicity characteristics of DDVP as an inhibitor of AChE on the swimming behavior of organisms were the same, and the AChE activity inhibition could induce loss of the nerve conduction ability, causing hyperactivity, loss of coordination, convulsions, paralysis and other kinds of behavioral changes, which was illustrated by the stepwise behavioral responses under different environmental stresses. "
5.	Acute Lung Injury 01/01/2013 - "In this study, we examined the effects of penehyclidine hydrochloride (PHC), a selective M-receptor inhibitor, on dichlorvos-induced acute lung injury in swine. " 01/01/2013 - "The PHC group showed mild impairment in pathology, less apoptotic cells, and little impact on cardiac function compared with the atropine group in dichlorvos-induced acute lung injury." 01/01/2013 - "Protective effects of penehyclidine hydrochloride on acute lung injury caused by severe dichlorvos poisoning in swine."

Related Drugs and Biologics

1.	Dichlorvos
2.	Trichlorfon (Metrifonate)
3.	pralidoxime (Protopam Chloride)
4.	Purinergic P1 Receptors (Adenosine Receptor)
5.	Magnesium Sulfate (Sulfate, Magnesium)
6.	penehyclidine
7.	N(6)-cyclopentyladenosine
8.	Atropine (Hyoscyamine)
9.	Cholinesterases (Cholinesterase)
10.	Soman

Related Therapies and Procedures

1.	Hemoperfusion
2.	Subcutaneous Injections
3.	Aftercare (After-Treatment)
4.	Deep Sedation
5.	Artificial Respiration (Mechanical Ventilation)