Dichloroacetate (Dichloroacetic Acid)

An acetic acid derivative that is a metabolite of TRICHLOROETHYLENE and is formed during chlorine disinfection of drinking water. It has effects on GLUCOSE metabolism, lowers LACTATE, and activates the PYRUVATE DEHYDROGENASE COMPLEX.

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Networked: 405 relevant articles (30 outcomes, 68 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Stacpoole, Peter W: 16 articles (04/2015 - 04/2003)
2.	Michelakis, Evangelos D: 9 articles (06/2015 - 01/2002)
3.	Shroads, Albert L: 8 articles (12/2013 - 04/2003)
4.	Archer, Stephen L: 8 articles (03/2013 - 01/2002)
5.	Lopaschuk, Gary D: 7 articles (11/2015 - 01/2002)
6.	Board, Philip G: 6 articles (02/2012 - 05/2002)
7.	Blackburn, Anneke C: 5 articles (02/2012 - 02/2006)
8.	James, Margaret O: 4 articles (04/2015 - 03/2008)
9.	Neiberger, Richard E: 4 articles (06/2013 - 02/2006)
10.	Dyck, Jason R B: 4 articles (05/2012 - 01/2002)

Related Diseases

1.	Lactic Acidosis 01/01/1988 - "Sodium dichloroacetate (NaDCA) has been used successfully to treat clinical and experimentally-induced lactic acidosis. " 05/01/2006 - "Open-label studies indicate that oral dichloroacetate (DCA) may be effective in treating patients with congenital lactic acidosis. " 08/18/1983 - "We conclude that dichloroacetate is a safe and effective adjunct in the treatment of patients with lactic acidosis, although the ultimate prognosis may depend on the underlying disease." 01/01/1990 - "Reduction in spinal cord postischemic lactic acidosis and functional improvement with dichloroacetate." 04/01/1986 - "Although dichloroacetate (DCA) ameliorates type B lactic acidosis, its effectiveness in type A hypoxic lactic acidosis is uncertain on both theoretical and experimental grounds. "
2.	Ischemia 06/01/2007 - "The purpose of this study was to determine the effects of dichloroacetate (DCA) in acute limb ischemia. " 01/01/1998 - "In this study we characterized the metabolic effects of dichloroacetate in a human model of peripheral muscle ischemia. " 06/01/1996 - "This study was undertaken to determine the effect of dichloroacetate (DCA) on myocardial functional and metabolic recovery following global ischemia. " 12/01/1995 - "Improvement of myocardial ischemic dysfunction with dichloroacetic acid: experimental study by repeated ischemia in dogs." 04/01/1994 - "This study was undertaken to determine the effect of dichloroacetate (DCA) on myocardial functional and metabolic recovery following global ischemia. "
3.	Brain Ischemia (Cerebral Ischemia) 12/01/1992 - "It suggested that dichloroacetate might across blood-brain barrier into the cerebral ischemic region and lowered lactic level, improved brain internal environment, relieved cerebral damage after focal cerebral ischemia or during blood reperfusion. " 01/01/1994 - "Dichloroacetate attenuates neuronal damage in a gerbil model of brain ischemia." 09/01/1998 - "Numerous studies using adult animal models suggest that dichloroacetate (DCA) may have neuroprotective properties by virtue of its ability to increase rates of metabolism and, therefore, clearance of brain lactic acidosis, which may accumulate during cerebral ischemia. " 08/31/1987 - "Although sodium dichloroacetate (DCA) has been shown to lower brain lactate in incomplete cerebral ischemia, functional outcome has not been assessed with DCA. " 12/01/1992 - "The lactic level decreased rapidly to treat with dichloroacetate (50 mg/kg body weight) after cerebral ischemia or during blood reperfusion, 14.11 +/- 2.06 and 13.23 +/- 1.71 mumol/g brain wight respectively, brain edema and pathology improved significantly. "
4.	Neoplasms (Cancer) 01/01/2015 - "Dichloroacetate (DCA) is beneficial in cancer therapy because it induces apoptosis and decreases cancer growth in vitro and in vivo without affecting non-cancer cells. " 01/01/2011 - "We posited that safety and efficacy of bicarbonate could be enhanced by dichloroacetate (DCA), a drug that selectively targets tumor cells and reduces extracellular acidity through inhibition of glycolysis. " 06/01/2015 - "A phase I open-labeled, single-arm, dose-escalation, study of dichloroacetate (DCA) in patients with advanced solid tumors." 06/01/2013 - "Human cell line studies show that dichloroacetate switches alter the metabolomics of the cancer cell from one of glycolysis to oxidative phosphorylation, and in doing so restore mitochondrial functions that trigger apoptosis of the cancer cell. " 09/01/2010 - "A current study shows that sodium dichloroacetate (DCA) can induce cancer cell apoptosis and inhibit tumor growth, but its cytotoxic activity is low (IC(50) > 1000 microM for A549). "
5.	Acidosis 02/01/1994 - "The use of dichloroacetate in the treatment of overwhelming hypoxic acidosis." 01/01/1991 - "These data give some further insights in the actions of dichloroacetate and support the use of dichloroacetate as alternative therapy in various forms of metabolic acidosis." 09/01/1990 - "These results indicate that dichloroacetate attenuates the myocardial acidosis and metabolic changes during coronary partial occlusion." 09/01/1990 - "Dichloroacetate attenuates myocardial acidosis and metabolic changes induced by partial occlusion of the coronary artery in dogs." 02/01/2012 - "Dichloroacetic acid (DCA) has potential for use in cancer therapy and the treatment of metabolic acidosis. "

Related Drugs and Biologics

1.	Lactic Acid
2.	Pyruvic Acid (Pyruvate)
3.	Glucose (Dextrose)
4.	Oxidoreductases
5.	Pyruvate Dehydrogenase Complex (Dehydrogenase Complex, Pyruvate)
6.	Sodium Bicarbonate (Baking Soda)
7.	Tromethamine (Trometamol)
8.	Trimetazidine (Vastarel)
9.	pyruvate dehydrogenase (acetyl-transferring) kinase (pyruvate dehydrogenase kinase)
10.	Insulin (Novolin)

Related Therapies and Procedures

1.	Ligation
2.	Radiotherapy
3.	Drug Therapy (Chemotherapy)
4.	Cardiopulmonary Resuscitation (CPR)
5.	Transplants (Transplant)